INT110784

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Context Info
Confidence 0.21
First Reported 2003
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.32
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Notch1) Golgi apparatus (Notch1) plasma membrane (Notch1)
nucleus (Notch1) embryo development (Notch1) cytoplasm (Notch1)
Anatomy Link Frequency
Notch 6
plasma 1
cleavage 1
Notch1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 27 99.64 Very High Very High Very High
Abeta 7 99.10 Very High Very High Very High
Potency 4 94.00 High High
Inflammation 4 53.28 Quite High
Kinase C 6 5.00 Very Low Very Low Very Low
sodium channel 3 5.00 Very Low Very Low Very Low
Eae 3 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
long-term potentiation 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 10 98.28 Very High Very High Very High
Disease 154 94.80 High High
INFLAMMATION 11 90.88 High High
Amyloid Plaque 5 82.12 Quite High
Alzheimer's Dementia 26 78.80 Quite High
Body Weight 16 52.64 Quite High
Apoptosis 7 35.44 Quite Low
Targeted Disruption 26 5.00 Very Low Very Low Very Low
Adhesions 8 5.00 Very Low Very Low Very Low
Congenital Anomalies 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Proteolysis mediated Notch signaling regulation
Protein_catabolism (Proteolysis) of Notch in Notch
1) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0.05 Pain Relevance 0
In contrast to gamma-secretase inhibitors, Abeta42-lowering NSAIDs do not impair S3 cleavage in the NOTCH receptor and release of the NOTCH intracellular domain, a finding with conceptual implications for the development of safer drugs targeting Abeta production through gamma-secretase modulation.
Protein_catabolism (cleavage) of NOTCH in cleavage associated with cinod and abeta
2) Confidence 0.08 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12777371 Disease Relevance 0.33 Pain Relevance 0.55
Many inhibitors of this protease have been identified, although the clinical use has been limited by concerns about the possible toxicity of these compounds. gamma-secretase inhibitors have been shown to reduce Abeta in vitro and in vivo, but interference with Notch proteolysis causes immunological and gastrointestinal toxicity in animal models.
Protein_catabolism (proteolysis) of Notch in Notch associated with toxicity and abeta
3) Confidence 0.07 Published 2010 Journal Curr Drug Targets Section Abstract Doc Link 20015011 Disease Relevance 1.05 Pain Relevance 0.48
lowering agents that likewise leave Notch proteolysis intact.
Protein_catabolism (proteolysis) of Notch in Notch
4) Confidence 0.06 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2604888 Disease Relevance 0.32 Pain Relevance 0
-cleavage of APP or Notch [78].
Protein_catabolism (cleavage) of Notch in Notch
5) Confidence 0.05 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.09 Pain Relevance 0
The cleavage of various substrates appears to be dependent on the subcellular compartment; APP is mainly cleaved in the TGN and early endosomal domains whereas Notch is primarily cleaved at the plasma membrane [34,36,123].
Protein_catabolism (cleaved) of Notch in plasma
6) Confidence 0.05 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.09 Pain Relevance 0
production in secondary assays, and to leave Notch proteolysis unaffected in tertiary assays.
Neg (unaffected) Protein_catabolism (proteolysis) of Notch in Notch
7) Confidence 0.04 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604888 Disease Relevance 0.29 Pain Relevance 0.08
-secretase level with little or no effect on Notch proteolysis.
Protein_catabolism (proteolysis) of Notch in Notch
8) Confidence 0.04 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604888 Disease Relevance 0.09 Pain Relevance 0.20

General Comments

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