INT110785

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Context Info
Confidence 0.05
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.33
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Notch1) Golgi apparatus (Notch1) plasma membrane (Notch1)
nucleus (Notch1) embryo development (Notch1) cytoplasm (Notch1)
Anatomy Link Frequency
cleavage 2
Notch1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 7 99.84 Very High Very High Very High
Abeta 1 94.36 High High
Disease Link Frequency Relevance Heat
Disease 1 90.44 High High
INFLAMMATION 2 88.08 High High
Alzheimer's Dementia 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to gamma-secretase inhibitors, Abeta42-lowering NSAIDs do not impair S3 cleavage in the NOTCH receptor and release of the NOTCH intracellular domain, a finding with conceptual implications for the development of safer drugs targeting Abeta production through gamma-secretase modulation.
Positive_regulation (impair) of Protein_catabolism (cleavage) of NOTCH in cleavage associated with cinod and abeta
1) Confidence 0.05 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12777371 Disease Relevance 0.33 Pain Relevance 0.55

General Comments

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