INT110806

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Context Info
Confidence 0.46
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.64
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp8) extracellular space (Mmp8) extracellular region (Mmp8)
proteinaceous extracellular matrix (Mmp8)
Anatomy Link Frequency
corneas 2
tears 1
Mmp8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 85 98.80 Very High Very High Very High
Inflammation 42 83.36 Quite High
agonist 1 73.04 Quite High
nMDA receptor 42 65.92 Quite High
Arthritis 5 62.16 Quite High
bradykinin 4 50.00 Quite Low
Inflammatory response 7 21.52 Low Low
acular 4 10.00 Low Low
Spinal cord 17 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Periodontal Disease 48 99.36 Very High Very High Very High
Alveolar Bone Loss 1 98.56 Very High Very High Very High
Diabetes Mellitus 22 88.16 High High
INFLAMMATION 56 83.36 Quite High
Adhesions 20 83.12 Quite High
Wound Healing 14 64.72 Quite High
Disease 28 63.52 Quite High
Arthritis 6 62.16 Quite High
Cardiovascular Disease 12 58.40 Quite High
Stress 30 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The corneas were excised and processed for immunohistochemical staining, Western blot assay, and zymography studies to determine the localization of the production of the following matrix metalloproteinases (MMPs): MMP-1, MMP-2, MMP-8, and MMP-9.
Positive_regulation (following) of MMP-8 in corneas
1) Confidence 0.46 Published 2003 Journal J Cataract Refract Surg Section Body Doc Link 12781288 Disease Relevance 0.06 Pain Relevance 0
The MMP-1 and MMP-8 expression levels were higher in intact corneas in the diclofenac sodium groups than in the ketorolac and artificial tears groups.
Positive_regulation (higher) of MMP-8 in tears
2) Confidence 0.43 Published 2003 Journal J Cataract Refract Surg Section Body Doc Link 12781288 Disease Relevance 0 Pain Relevance 0
CONCLUSION: These results indicate that BK at reperfusion triggers its protective signalling pathway through MMP-8-dependent transactivation of the EGFR.


Positive_regulation (transactivation) of MMP-8-dependent
3) Confidence 0.34 Published 2009 Journal Acta Physiol (Oxf) Section Body Doc Link 19583703 Disease Relevance 0 Pain Relevance 0
These studies also disclosed that the application of the present ophthalmic fluoroquinolone solutions (Ciloxan, Ocuflox and Quixin) increases MMP-1, MMP-8 (immunoblots, figure 2) and MMP-2, MMP-9 (zymography, figure 3) expression in both intact and wounded corneas although the levels of expression may be slightly different among various groups.
Positive_regulation (increases) of MMP-8 in corneas
4) Confidence 0.14 Published 2003 Journal BMC Ophthalmol Section Body Doc Link PMC239861 Disease Relevance 0.06 Pain Relevance 0.11
MMP 8, the interstitial collagenase, was elevated 4.77 ± 1.44 fold with MCT treatment.
Positive_regulation (elevated) of MMP 8
5) Confidence 0.14 Published 2005 Journal Respir Res Section Body Doc Link PMC1291406 Disease Relevance 0.30 Pain Relevance 0.04
The presence of MMP-8 or both MMP-2 and MMP-9-inhibitors during NMDA stimulation did not prevent the loss of extracellular NR1 epitopes (data not shown).
Positive_regulation (presence) of MMP-8
6) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2443283 Disease Relevance 0 Pain Relevance 0.26
In a rat model of induced periodontal disease using gingival LPS injections, elevated levels of collagenase (MMP-8), gelatinase (MMP-9), elastase and alveolar bone loss were overcome by using a synergistic combination of sub-optimal doses of the chemically modified tetracycline CMT-8 and a biphosphonate, clodronate [86]; when sub-optimal doses of these agents were used individually, there were negligible effects on the above parameters.
Positive_regulation (elevated) of MMP-8 associated with alveolar bone loss and periodontal disease
7) Confidence 0.04 Published 2008 Journal The Open Dentistry Journal Section Body Doc Link PMC2581528 Disease Relevance 1.21 Pain Relevance 0.26

General Comments

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