INT110809

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 20
Total Number 44
Disease Relevance 18.00
Pain Relevance 14.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
tears 10
cornea 4
tendons 2
stroma 1
hepatocytes 1
Mmp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 2003 100.00 Very High Very High Very High
cytokine 40 99.40 Very High Very High Very High
Catecholamine 2 99.18 Very High Very High Very High
Arthritis 11 98.44 Very High Very High Very High
fibrosis 120 98.28 Very High Very High Very High
cINOD 32 97.28 Very High Very High Very High
rheumatoid arthritis 18 97.12 Very High Very High Very High
Inflammation 94 95.88 Very High Very High Very High
chemokine 8 92.72 High High
intrathecal 1 90.48 High High
Disease Link Frequency Relevance Heat
Cirrhosis 120 99.84 Very High Very High Very High
Rotator Cuff Tears 720 99.82 Very High Very High Very High
Injury 139 99.24 Very High Very High Very High
Experimental Arthritis 6 98.80 Very High Very High Very High
Tendinopathy 126 98.52 Very High Very High Very High
Fibrosis 84 98.28 Very High Very High Very High
Disease 189 97.60 Very High Very High Very High
Rheumatoid Arthritis 19 97.12 Very High Very High Very High
Syndrome 24 96.44 Very High Very High Very High
Arthropathy 168 96.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MMPs and TIMPs protein expression
Gene_expression (expression) of MMP associated with metalloproteinase
1) Confidence 0.75 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844613 Disease Relevance 0.64 Pain Relevance 0.41
MMPs are expressed in HSCs or hepatocytes (22), whereas TIMP-1 and TIMP-2 are expressed only in HSCs (23).
Gene_expression (expressed) of MMP in hepatocytes associated with cirrhosis and metalloproteinase
2) Confidence 0.75 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844613 Disease Relevance 1.15 Pain Relevance 0.48
MMP 1 expression was significantly higher in this group when compared with controls (p = 0.021).
Gene_expression (expression) of MMP 1 associated with metalloproteinase
3) Confidence 0.67 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2998463 Disease Relevance 0.39 Pain Relevance 0.45
Groups II and IV showed no significant difference in MMP 1 expression.
Gene_expression (expression) of MMP 1 associated with metalloproteinase
4) Confidence 0.67 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2998463 Disease Relevance 0.39 Pain Relevance 0.49
The indirect action of these molecules through MMPs may aid to generate different changes in the endometrial stroma during maternal recognition of pregnancy [44]
Gene_expression (action) of MMP in stroma
5) Confidence 0.65 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0 Pain Relevance 0.19
MMP-13, the interstitial collagenase in rodents, is a specific protease capable of degrading fibrillar collagen (3).
Gene_expression (protease) of interstitial collagenase
6) Confidence 0.65 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844613 Disease Relevance 0.55 Pain Relevance 0.40
There was no correlation between MMP 1, 3, and 9 expression and increasing Bateman grade.


Gene_expression (expression) of MMP 1 associated with metalloproteinase
7) Confidence 0.58 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2998463 Disease Relevance 0.40 Pain Relevance 0.52
We demonstrated that MMP 1 and 9 expression is increased, and MMP 3 expression is decreased in degenerated LHB compared with healthy controls.
Gene_expression (expression) of MMP 1 associated with metalloproteinase
8) Confidence 0.58 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2998463 Disease Relevance 0.72 Pain Relevance 0.25
Interestingly, in an experimental study on cultured rat Achilles tendon cells published recently, Tsai et al. could reveal an upregulated expression of MMP 1, 8, 9 and 13 after incubation of the cells with ibuprofen a common NSAID that is popular in the treatment of degenerative tendon disease [36].
Gene_expression (expression) of MMP 1 in tendon associated with cinod, metalloproteinase and disease
9) Confidence 0.58 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2998463 Disease Relevance 0.47 Pain Relevance 0.35
Our findings confirmed these observations, in that MMP 1 and 9 expression was significantly higher in "A" versus "B" tears.
Gene_expression (expression) of MMP 1 in tears associated with metalloproteinase
10) Confidence 0.58 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2998463 Disease Relevance 0.59 Pain Relevance 0.17
However, multiple authors have confirmed our findings, of increased MMP 1 and 9 as well as decreased MMP 3 expression in degenerated Achilles tendons [26-28].
Gene_expression (expression) of MMP 1 in tendons associated with metalloproteinase
11) Confidence 0.58 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2998463 Disease Relevance 0.35 Pain Relevance 0.49
MCL gene expression of collagen type I, collagen type III, collagen type V, fibronectin, decorin, biglycan, lysyl oxidase, matrix metalloproteinase-2, and tissue inhibitor of matrix metalloproteinase-1, measured by real-time quantitative PCR, demonstrated differential expression in the HLU-healing groups compared with Amb-healing groups at both the 3- and 7-wk time points.
Gene_expression (expression) of matrix metalloproteinase-1 in MCL associated with metalloproteinase
12) Confidence 0.58 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17699562 Disease Relevance 0.22 Pain Relevance 0.22
It is known that the expression of MMPs/TIMPs plays an important role in the control of implantation.
Gene_expression (expression) of MMP
13) Confidence 0.58 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0 Pain Relevance 0
Following liver injury, HSCs are activated and increase the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) (3, 4).
Gene_expression (expression) of MMP in HSCs associated with cirrhosis, injury and metalloproteinase
14) Confidence 0.58 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844613 Disease Relevance 1.22 Pain Relevance 0.50
The MMP-1 and MMP-8 expression levels were higher in intact corneas in the diclofenac sodium groups than in the ketorolac and artificial tears groups.
Gene_expression (expression) of MMP-1 in tears
15) Confidence 0.52 Published 2003 Journal J Cataract Refract Surg Section Body Doc Link 12781288 Disease Relevance 0 Pain Relevance 0
The corneas were excised and processed for immunohistochemical staining, Western blot assay, and zymography studies to determine the localization of the production of the following matrix metalloproteinases (MMPs): MMP-1, MMP-2, MMP-8, and MMP-9.
Spec (determine) Gene_expression (production) of MMP-1 in corneas
16) Confidence 0.52 Published 2003 Journal J Cataract Refract Surg Section Body Doc Link 12781288 Disease Relevance 0.06 Pain Relevance 0
CONCLUSION: This study provides preliminary evidence that topical application of some NSAIDs can induce the early expression of MMP-1, MMP-2, and MMP-8 in the cornea, suggesting that MMPs play a role in the corneal cytotoxicity of certain NSAIDs.


Gene_expression (expression) of MMP-1 in cornea
17) Confidence 0.52 Published 2003 Journal J Cataract Refract Surg Section Body Doc Link 12781288 Disease Relevance 0 Pain Relevance 0
When comparing the histologic and molecular changes of the intraarticular and extraarticular LHB after tenotomy, Joseph et al. described increased MMP 1 and MMP 3 expression associated with histologic signs of tendinopathy [17].
Gene_expression (expression) of MMP 1 associated with metalloproteinase and tendinopathy
18) Confidence 0.52 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2998463 Disease Relevance 0.43 Pain Relevance 0.39
MMP 1 expression was significantly higher than in the control group but not significantly augmented in comparison with groups II and III (p = 0.025).
Gene_expression (expression) of MMP 1 associated with metalloproteinase
19) Confidence 0.52 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2998463 Disease Relevance 0.32 Pain Relevance 0.60
No statistical correlation could be found between expression of MMP1, MMP 3 and MMP 9 and the age of the 116 included patients.
Gene_expression (expression) of MMP1 associated with metalloproteinase
20) Confidence 0.52 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2998463 Disease Relevance 0.38 Pain Relevance 0.54

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox