INT110811

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Context Info
Confidence 0.60
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 10
Disease Relevance 2.96
Pain Relevance 2.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
tears 2
corneas 2
supraspinatus 1
tendons 1
Mmp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 452 100.00 Very High Very High Very High
antagonist 1 90.00 High High
alcohol 13 65.48 Quite High
Osteoarthritis 18 47.56 Quite Low
Inflammation 14 18.80 Low Low
acular 4 10.00 Low Low
shoulder pain 12 5.00 Very Low Very Low Very Low
cINOD 8 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 35 99.36 Very High Very High Very High
Hypoxia 1 98.24 Very High Very High Very High
Rotator Cuff Tears 180 97.84 Very High Very High Very High
Cadaver 12 93.32 High High
Tendinopathy 31 89.96 High High
Aging 6 88.36 High High
Sprains And Strains 12 87.28 High High
Injury 27 85.08 High High
Disease 45 78.00 Quite High
Amputation 6 68.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, it has been shown that increased MMP 1 activity occurs in ruptured human supraspinatus tendons [24].
Positive_regulation (increased) of MMP 1 in supraspinatus associated with metalloproteinase
1) Confidence 0.60 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2998463 Disease Relevance 0.40 Pain Relevance 0.41
However, multiple authors have confirmed our findings, of increased MMP 1 and 9 as well as decreased MMP 3 expression in degenerated Achilles tendons [26-28].
Positive_regulation (increased) of MMP 1 in tendons associated with metalloproteinase
2) Confidence 0.52 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2998463 Disease Relevance 0.34 Pain Relevance 0.49
Compared with controls, both MMP 1 and 9 expression was significantly increased whereas MMP 3 expression was significantly decreased (p = 0.027 and 0.035, respectively).
Positive_regulation (increased) of MMP 1 associated with metalloproteinase
3) Confidence 0.38 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2998463 Disease Relevance 0.26 Pain Relevance 0.35
We demonstrated that MMP 1 and 9 expression is increased, and MMP 3 expression is decreased in degenerated LHB compared with healthy controls.
Positive_regulation (increased) of MMP 1 associated with metalloproteinase
4) Confidence 0.38 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2998463 Disease Relevance 0.72 Pain Relevance 0.25
Higher levels of MMP 1 and 9 were found in "A" versus "B" partial thickness rotator cuff tears (p = 0.039, Figure 2a-b).


Positive_regulation (levels) of MMP 1 in tears associated with metalloproteinase and rotator cuff tears
5) Confidence 0.35 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2998463 Disease Relevance 0.27 Pain Relevance 0.38
Joseph et al. were the first to describe increased levels of MMP 1 and 3 in the intraarticular (compared to the extraarticular) portion of the LHB [17].
Positive_regulation (increased) of MMP 1 associated with metalloproteinase
6) Confidence 0.35 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2998463 Disease Relevance 0.25 Pain Relevance 0.59
The corneas were excised and processed for immunohistochemical staining, Western blot assay, and zymography studies to determine the localization of the production of the following matrix metalloproteinases (MMPs): MMP-1, MMP-2, MMP-8, and MMP-9.
Positive_regulation (following) of MMP-1 in corneas
7) Confidence 0.34 Published 2003 Journal J Cataract Refract Surg Section Body Doc Link 12781288 Disease Relevance 0.06 Pain Relevance 0
The MMP-1 and MMP-8 expression levels were higher in intact corneas in the diclofenac sodium groups than in the ketorolac and artificial tears groups.
Positive_regulation (higher) of MMP-1 in tears
8) Confidence 0.31 Published 2003 Journal J Cataract Refract Surg Section Body Doc Link 12781288 Disease Relevance 0 Pain Relevance 0
These studies also disclosed that the application of the present ophthalmic fluoroquinolone solutions (Ciloxan, Ocuflox and Quixin) increases MMP-1, MMP-8 (immunoblots, figure 2) and MMP-2, MMP-9 (zymography, figure 3) expression in both intact and wounded corneas although the levels of expression may be slightly different among various groups.
Positive_regulation (increases) of MMP-1 in corneas
9) Confidence 0.29 Published 2003 Journal BMC Ophthalmol Section Body Doc Link PMC239861 Disease Relevance 0.06 Pain Relevance 0.11
In addition, MMP 1, an interstitial collagenase, is upregulated in MCT-induced PAH [6].
Positive_regulation (upregulated) of MMP 1 associated with pulmonary hypertension
10) Confidence 0.07 Published 2005 Journal Respir Res Section Body Doc Link PMC1291406 Disease Relevance 0.59 Pain Relevance 0.26

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