INT110819

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.57
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pln) protein complex (Pln)
Anatomy Link Frequency
muscles 1
PSP 1
Pln (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 35 94.44 High High
cINOD 1 93.60 High High
diclofenac 10 93.12 High High
anesthesia 2 73.84 Quite High
tolerance 2 58.76 Quite High
Inflammation 6 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 7 98.68 Very High Very High Very High
Coronary Heart Disease 5 91.68 High High
Sprains And Strains 46 88.40 High High
Immunization 2 73.72 Quite High
Targeted Disruption 14 62.64 Quite High
Pulmonary Disease 4 57.20 Quite High
Hypertension 1 54.44 Quite High
Hypersensitivity 16 50.00 Quite Low
Anaphylaxis 6 12.76 Low Low
Hypertrophy 15 7.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was found that either (1) unfractionated splenocytes or (2) purified CD8(+) splenocytes, but not (3) purified CD4(+) splenocytes isolated from mice gavaged with OX adoptively transferred PLN suppression to naive BALB/c mice.
Negative_regulation (suppression) of PLN
1) Confidence 0.42 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 12781630 Disease Relevance 0 Pain Relevance 0.44
Alveolar hypoxia induced a 38%, 47%, and 27% reduction in Ser16-phosphorylated phospholamban (PLB) in the RV after 1, 2, and 4 wk of hypoxia, respectively, and at the same time points, Ser16-phosphorylated PLB in the LV was downregulated by 32%, 34%, and 25% (all P < 0.05).
Negative_regulation (downregulated) of PLB associated with hypoxia
2) Confidence 0.37 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16582020 Disease Relevance 1.08 Pain Relevance 0.07
Similar to previous observations [23] the mass of the GTN, SOL, EDL, and PLN muscles were unaffected by the loss of PTEN (Figure 3).
Negative_regulation (cles were ) of PLN in muscles
3) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.11 Pain Relevance 0
Five days after injection of OVA+PSP, OVA, PSP and buffer (HBSS) into the footpad, the PLN cell numbers were determined, and the amount of IL-4, IFN-?
Negative_regulation (numbers) of PLN in PSP
4) Confidence 0.15 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1182367 Disease Relevance 0.37 Pain Relevance 0.09

General Comments

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