INT110830

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Context Info
Confidence 0.34
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.91
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Mns1) nucleus (Mns1)
Anatomy Link Frequency
juvenile 1
MNs 1
Mns1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 32 99.80 Very High Very High Very High
depression 52 98.60 Very High Very High Very High
analgesia 8 97.28 Very High Very High Very High
repetitive firing 2 96.00 Very High Very High Very High
Glutamate receptor 4 89.40 High High
narcan 2 82.24 Quite High
antagonist 4 81.52 Quite High
Neurotransmitter 4 78.80 Quite High
Glutamate 16 77.44 Quite High
Opioid 30 74.08 Quite High
Disease Link Frequency Relevance Heat
Depression 46 98.60 Very High Very High Very High
Injury 3 91.88 High High
Respiratory Failure 6 79.64 Quite High
Sleep Disorders 4 71.76 Quite High
Apnoea 4 69.64 Quite High
Central Sleep Apnea 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In animals treated with Ac-DEVD-CHO, a caspase-3-specific inhibitor, and Boc-D-FMK, 44 and 62% of MNs, respectively, were found to regenerate their axons into a PN graft implanted immediately after root avulsion.
Negative_regulation (inhibitor) of MNs in MNs
1) Confidence 0.34 Published 2003 Journal Exp. Neurol. Section Abstract Doc Link 12781992 Disease Relevance 0.25 Pain Relevance 0
In contrast, activation of mACh receptors suppresses the activity of juvenile XII MNs in vitro, via presynaptic inhibition of evoked glutamatergic excitatory inputs [35].
Negative_regulation (suppresses) of MNs in juvenile
2) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808240 Disease Relevance 0.13 Pain Relevance 0.17
These data have led us to first assess whether an opiate-mediated inhibition of XII MNs contributes to the opiate-induced depression of breathing, and second, to examine the utility of AMPAKINES in reversing the opiate-mediated inhibition of XII inspiratory motor output.
Spec (whether) Negative_regulation (inhibition) of MNs associated with depression and opiate
3) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808240 Disease Relevance 0.53 Pain Relevance 1.47

General Comments

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