INT110835

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.36
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (SPTLC2, SPTLC1) endoplasmic reticulum (SPTLC2, SPTLC1) biosynthetic process (SPTLC2, SPTLC1)
transferase activity, transferring acyl groups (SPTLC2, SPTLC1) mitochondrion (SPTLC2)
Anatomy Link Frequency
reticulum 2
SPTLC2 (Homo sapiens)
SPTLC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hsan 189 87.88 High High
Pain 8 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
unmyelinated 4 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
lancinating pain 2 5.00 Very Low Very Low Very Low
syringomyelia 2 5.00 Very Low Very Low Very Low
Demyelination 2 5.00 Very Low Very Low Very Low
diabetic neuropathy 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Peripheral Neuropathy 2 91.04 High High
Hereditary Sensory And Autonomic Neuropathies 203 87.88 High High
Repression 2 82.88 Quite High
Apoptosis 3 77.52 Quite High
Stress 1 74.48 Quite High
Disease 49 63.52 Quite High
Neuropathic Pain 26 57.64 Quite High
Syndrome 14 5.00 Very Low Very Low Very Low
Infection 12 5.00 Very Low Very Low Very Low
Charcot Marie Tooth Disease 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SPT in humans consists of two hetero subunits, SPTLC1 and SPTLC2 (or LCB1 and LCB2 in mammals), which are both bound to the endoplasmic reticulum (ER) [21].
SPTLC2 Binding (bound) of SPTLC1 in reticulum
1) Confidence 0.42 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2311280 Disease Relevance 0.54 Pain Relevance 0.31
SPT in humans consists of two hetero subunits, SPTLC1 and SPTLC2 (or LCB1 and LCB2 in mammals), which are both bound to the endoplasmic reticulum (ER) [21].
SPTLC2 Binding (bound) of LCB1 in reticulum
2) Confidence 0.42 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2311280 Disease Relevance 0.53 Pain Relevance 0.30
LCB2 appears to be unstable unless it is associated with LCB1.
LCB2 Binding (associated) of LCB1
3) Confidence 0.35 Published 2003 Journal Biochim. Biophys. Acta Section Abstract Doc Link 12782147 Disease Relevance 0.28 Pain Relevance 0.07

General Comments

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