INT110836

Context Info Confidence 0.30 First Reported 2003 Last Reported 2003 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.11 Pain Relevance 0

small molecule metabolic process (AGXT, SPTLC1) mitochondrion (AGXT) endoplasmic reticulum (SPTLC1) biosynthetic process (SPTLC1) peroxisome (AGXT) transferase activity, transferring acyl groups (SPTLC1)

Anatomy Link Frequency reticulum 1 AGXT (Homo sapiens) SPTLC1 (Homo sapiens)

Pain Link Frequency Relevance Heat Hsan 1 48.80

Disease Link Frequency Relevance Heat Apoptosis 1 57.04 Stress 1 54.00 Hereditary Sensory And Autonomic Neuropathies 1 48.80 Disease 1 43.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Mammalian SPT is a heterodimer of 53-kDa LCB1 and 63-kDa LCB2 subunits, both of which are bound to the endoplasmic reticulum (ER) most likely with the type I topology, whereas other members of the POAS family are soluble homodimer enzymes.

Mammalian SPT Binding (heterodimer) of LCB1 in reticulum

1) Confidence 0.30 Published 2003 Journal Biochim. Biophys. Acta Section Abstract Doc Link 12782147 Disease Relevance 0.11 Pain Relevance 0

General Comments

This test has worked.