INT110838

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Context Info
Confidence 0.46
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.21
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (AGXT) small molecule metabolic process (AGXT) peroxisome (AGXT)
cellular nitrogen compound metabolic process (AGXT)
AGXT (Homo sapiens)
Pain Link Frequency Relevance Heat
Hsan 191 98.06 Very High Very High Very High
antagonist 5 94.20 High High
b2 receptor 3 93.76 High High
adenocard 62 90.20 High High
bradykinin 41 76.32 Quite High
Peripheral nervous system 1 70.28 Quite High
Pain 8 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
unmyelinated 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 51 99.06 Very High Very High Very High
Peripheral Neuropathy 2 98.56 Very High Very High Very High
Hereditary Sensory And Autonomic Neuropathies 211 98.06 Very High Very High Very High
Repression 2 94.96 High High
Stress 1 92.60 High High
Apoptosis 3 91.20 High High
Neurodegenerative Disease 1 68.96 Quite High
Neuropathic Pain 26 65.16 Quite High
Hypoxia 8 56.68 Quite High
Syndrome 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, the G387A mutation showed no influence on SPT activity.
Neg (no) Regulation (influence) of SPT
1) Confidence 0.46 Published 2009 Journal Neurogenetics Section Abstract Doc Link 19132419 Disease Relevance 0.67 Pain Relevance 0.18
Specific missense mutations in the human LCB1 gene cause hereditary sensory neuropathy type I, an autosomal dominantly inherited disease, and these mutations confer dominant-negative effects on SPT activity.
Regulation (effects) of SPT associated with disease and hsan
2) Confidence 0.38 Published 2003 Journal Biochim. Biophys. Acta Section Abstract Doc Link 12782147 Disease Relevance 0.38 Pain Relevance 0.10
Serine palmitoyltransferase (SPT) is a pyridoxal-5'-phosphate dependent enzyme, which is suggested to be a key enzyme for the regulation of sphingolipid levels in cells.
Regulation (regulation) of SPT
3) Confidence 0.12 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2311280 Disease Relevance 0.62 Pain Relevance 0.39
Regulation of sphingolipid synthesis at the SPT step prevents a harmful accumulation of metabolic sphingolipid-intermediates including sphingoid bases and ceramide, whereas repression of other anabolic steps in the spingolipid synthetic pathway may cause intermediates to accumulate.
Regulation (Regulation) of SPT associated with repression
4) Confidence 0.06 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2311280 Disease Relevance 0.47 Pain Relevance 0.24
The effect of MPG, SPT, and HOE140 alone was studied in separate groups exposed to 150 ?
Regulation (effect) of SPT
5) Confidence 0.02 Published 2010 Journal BMC Anesthesiol Section Body Doc Link PMC2919536 Disease Relevance 0.06 Pain Relevance 0.38

General Comments

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