INT11086

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Context Info
Confidence 0.45
First Reported 1992
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.22
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Drd2) signal transduction (Drd2) plasma membrane (Drd2)
signal transducer activity (Drd2)
Anatomy Link Frequency
neurons 2
jaw 2
Drd2 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 28 100.00 Very High Very High Very High
depression 12 99.88 Very High Very High Very High
Central nervous system 1 99.80 Very High Very High Very High
agonist 5 89.20 High High
dopamine receptor 4 75.00 Quite High
antagonist 3 64.80 Quite High
Pain 1 32.24 Quite Low
projection neuron 3 26.92 Quite Low
Enkephalin 6 25.00 Low Low
anesthesia 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Depression 12 99.88 Very High Very High Very High
Targeted Disruption 12 99.36 Very High Very High Very High
Li-fraumeni Syndrome 2 92.48 High High
Adenoma 1 89.28 High High
Pituitary Cancer 1 88.96 High High
Pain 1 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Methods which detect relatively high levels of expression of D1R or D2R, including BAC transgenic mice, clearly emphasize the segregation of these receptors in different neurons.
Regulation (detect) of Positive_regulation (levels) of D2R in neurons associated with targeted disruption
1) Confidence 0.45 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0.10 Pain Relevance 0
Due to the remarkable role of dopamine in central nervous system LTD, the influence of dopamine D2 receptor activation on LTD of the jaw-opening reflex (JOR) was investigated.
Regulation (influence) of Spec (investigated) Positive_regulation (activation) of dopamine D2 receptor in jaw associated with dopamine, depression and central nervous system
2) Confidence 0.16 Published 2005 Journal Brain Res. Section Abstract Doc Link 15713281 Disease Relevance 0.95 Pain Relevance 0.73
This rapid effect of estradiol also enhanced PRL mRNA, but did not affect other species of mRNA encoding for proenkephalin, D2 receptor mRNA, or hexosaminidase-A.
Neg (not) Regulation (affect) of Positive_regulation (encoding) of D2 receptor
3) Confidence 0.01 Published 1992 Journal Endocrinology Section Abstract Doc Link 1534540 Disease Relevance 0.18 Pain Relevance 0.12

General Comments

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