INT11087

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Context Info
Confidence 0.69
First Reported 1989
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 54
Total Number 58
Disease Relevance 12.40
Pain Relevance 31.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Drd2) signal transduction (Drd2) plasma membrane (Drd2)
signal transducer activity (Drd2)
Anatomy Link Frequency
striatum 9
neurons 5
nucleus accumbens 2
putamen 2
shell 1
Drd2 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 2230 100.00 Very High Very High Very High
agonist 268 100.00 Very High Very High Very High
antagonist 210 100.00 Very High Very High Very High
dopamine receptor 128 100.00 Very High Very High Very High
Enkephalin 56 100.00 Very High Very High Very High
gABA 25 100.00 Very High Very High Very High
addiction 30 99.92 Very High Very High Very High
depression 107 99.84 Very High Very High Very High
Nucleus accumbens 211 99.74 Very High Very High Very High
opioid receptor 4 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sprains And Strains 108 99.96 Very High Very High Very High
Targeted Disruption 94 99.96 Very High Very High Very High
Morphine Dependence 2 99.92 Very High Very High Very High
Depression 115 99.84 Very High Very High Very High
Lifespan 6 98.92 Very High Very High Very High
Syndrome 24 96.88 Very High Very High Very High
Hyperplasia 1 96.72 Very High Very High Very High
Hypertension 59 96.44 Very High Very High Very High
Catalepsy 5 95.40 Very High Very High Very High
Parkinson's Disease 24 95.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These new mouse lines, in which the enhanced green fluorescent protein (EGFP) is driven by D1R or D2R promoters, provide an easy way to label neurons which express high levels of D1R or D2R (reviewed in Valjent et al., 2009).
Positive_regulation (levels) of D2R in neurons
1) Confidence 0.69 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0.17 Pain Relevance 0.03
The expression of enkephalin mRNA in the striatum is increased in the D2R knockout mice.
Positive_regulation (increased) of D2R in striatum associated with targeted disruption and enkephalin
2) Confidence 0.56 Published 1999 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 10803208 Disease Relevance 0.90 Pain Relevance 0.45
At this time, the mice exhibited a 40% decrease in striatal dopamine content and an accompanying 46% increase in dopamine D2 receptor levels compared with control untreated mice.
Positive_regulation (increase) of dopamine D2 receptor associated with dopamine
3) Confidence 0.56 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10386973 Disease Relevance 0.40 Pain Relevance 0.41
The dopamine content returned to control levels, and the increase in dopamine D2 receptor levels was attenuated in mice treated with perindopril (5 mg/kg/day orally for 7 days) 2 weeks after the last dose of MPTP.
Positive_regulation (increase) of dopamine D2 receptor associated with parkinson's disease and dopamine
4) Confidence 0.56 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10386973 Disease Relevance 0.41 Pain Relevance 0.41
Methods which detect relatively high levels of expression of D1R or D2R, including BAC transgenic mice, clearly emphasize the segregation of these receptors in different neurons.
Positive_regulation (levels) of D2R in neurons associated with targeted disruption
5) Confidence 0.50 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0.10 Pain Relevance 0
Striatum/cerebellum and striatum/occipital cortex ratios of count rate density were calculated as a semiquantitative measurement for striatal dopamine D2-receptor binding potential.
Positive_regulation (measurement) of D2-receptor in cerebellum associated with dopamine
6) Confidence 0.48 Published 1993 Journal Cephalalgia Section Abstract Doc Link 8242725 Disease Relevance 0.16 Pain Relevance 0.63
Continuous treatment with the D2 dopamine receptor agonist quinpirole decreases D2 dopamine receptors, D2 dopamine receptor messenger RNA and proenkephalin messenger RNA, and increases mu opioid receptors in mouse striatum.
Positive_regulation (quinpirole) of D2 dopamine receptor in striatum associated with dopamine receptor, mu opioid receptor, agonist and enkephalin
7) Confidence 0.47 Published 1993 Journal Neuroscience Section Title Doc Link 8101360 Disease Relevance 0 Pain Relevance 0.75
Our results demonstrated that DA release and subsequent DA D1 and D2 receptor activation is essential for the development of sensitization to the rewarding effects of morphine.
Positive_regulation (activation) of D2 receptor associated with dopamine and morphine
8) Confidence 0.47 Published 2005 Journal Neuroreport Section Abstract Doc Link 15671878 Disease Relevance 0 Pain Relevance 0.89
Bronikowski and colleagues (2004) investigated gene expression changes in the
    hippocampus region of the brain and found that mice selectively bred for high wheel running had
    a 20% increase in D2 and D4 receptor expression (D1-like receptors were not analyzed in this
    study) compared to control line mice 16. 
Positive_regulation (increase) of D2 in hippocampus region associated with hippocampus
9) Confidence 0.43 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2836544 Disease Relevance 0.15 Pain Relevance 0.18
Additional evidence in rodents has suggested both D1-like and D2-like dopamine receptors, and
   the dopamine transporter gene may be a mediator in addictive behavior 53, 61, 155. 
Positive_regulation (suggested) of D2 associated with dopamine and dopamine receptor
10) Confidence 0.43 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2836544 Disease Relevance 0.05 Pain Relevance 0.38
Rats who undergo endurance training show increased
   D2 receptor binding over the lifespan compared to control animals, suggesting that endurance
   training provides some protection from age related loss of D2 receptor functioning 97. 
Positive_regulation (increased) of D2 associated with lifespan
11) Confidence 0.43 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2836544 Disease Relevance 0.51 Pain Relevance 0.20
Due to the remarkable role of dopamine in central nervous system LTD, the influence of dopamine D2 receptor activation on LTD of the jaw-opening reflex (JOR) was investigated.
Spec (investigated) Positive_regulation (activation) of dopamine D2 receptor in jaw associated with dopamine, depression and central nervous system
12) Confidence 0.41 Published 2005 Journal Brain Res. Section Abstract Doc Link 15713281 Disease Relevance 0.94 Pain Relevance 0.72
In addition to the expression of high levels of the rat dopamine D2-receptor, these mouse cells also express sigma binding sites.
Positive_regulation (levels) of D2-receptor associated with dopamine
13) Confidence 0.40 Published 1993 Journal Cell. Signal. Section Abstract Doc Link 8130078 Disease Relevance 0 Pain Relevance 0.35
Endogenous opioids mediate basal hedonic tone independent of dopamine D-1 or D-2 receptor activation.
Neg (independent) Positive_regulation (independent) of D-2 receptor associated with dopamine and endogenous opioid
14) Confidence 0.38 Published 2004 Journal Neuroscience Section Title Doc Link 14960355 Disease Relevance 0.12 Pain Relevance 0.86
Although the dopamine D1 antagonist SCH 23390 (0.01 and 0.03 mg/kg) did not influence behavior induced by apomorphine (0.03 mg/kg), the dopamine D2 antagonist sulpiride (3.0 mg/kg) reversed the decrease in circling and rearing behavior induced by apomorphine, suggesting that the effects of apomorphine on circling and rearing are mediated through dopamine D2 autoreceptors.
Positive_regulation (mediated) of dopamine D2 associated with dopamine and antagonist
15) Confidence 0.38 Published 1993 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 7904071 Disease Relevance 0 Pain Relevance 0.92
The reactivation effects of the delta-opioid receptor blockade and D2 dopamine receptor activation on the detention-induced memory deficit in mice were investigated, in order to study possible interactions between opioid and dopamine systems in memory retrieval.
Positive_regulation (activation) of D2 dopamine receptor associated with dopamine, dopamine receptor, opioid receptor and opioid
16) Confidence 0.37 Published 1996 Journal Behav. Brain Res. Section Abstract Doc Link 8883813 Disease Relevance 0 Pain Relevance 0.42
D2 DA receptor stimulation may also play an important role in enhancing the effectiveness of MK-801 in the treatment of opiate tolerance and dependence.
Positive_regulation (stimulation) of D2 DA receptor associated with addiction, dopamine, tolerance and opiate
17) Confidence 0.37 Published 1995 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 7549459 Disease Relevance 0.17 Pain Relevance 1.63
In the second part of the study, the animals received SCH23390 (D1 receptor antagonist), sulpiride (D2 receptor antagonist), L-Arg (nitric oxide precursor) and NG-nitro-L-Arg methylester (nitric oxide synthase inhibitor) during repeated morphine administration, to evaluate the role of dopamine receptor antagonists and nitric oxide agents in this phenomenon.
Positive_regulation (received) of D2 receptor associated with dopamine receptor, antagonist and morphine
18) Confidence 0.35 Published 2007 Journal Behav Pharmacol Section Abstract Doc Link 17426481 Disease Relevance 0 Pain Relevance 1.58
Increased DRD2 function was suggested to have occurred in a compensatory reaction to abnormally elevated dopamine levels at an early stage of development, perhaps as a result of exposure to stress and/or a genetic defect [80].
Positive_regulation (Increased) of DRD2 associated with stress and dopamine
19) Confidence 0.35 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.09 Pain Relevance 0.68
Results are consistent with increased endogenous activation of DRD2 in the nucleus accumbens while increased efficacy of endogenous dopamine activation of DRD2 autoreceptors was suggested to account for the decreased stimulus-evoked release of dopamine in SHR striatum [77].
Positive_regulation (activation) of DRD2 in nucleus accumbens associated with nucleus accumbens and dopamine
20) Confidence 0.35 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.12 Pain Relevance 0.74

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