INT110871

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Context Info
Confidence 0.15
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 14
Disease Relevance 7.92
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal 1
spinal cord 1
CSF 1
basal lamina 1
motoneurons 1
Cms1 (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 17 99.28 Very High Very High Very High
Spinal cord 281 98.72 Very High Very High Very High
antagonist 18 97.64 Very High Very High Very High
agonist 20 95.96 Very High Very High Very High
metalloproteinase 1 93.36 High High
depression 36 91.48 High High
Angina 8 90.24 High High
sodium channel 2 88.92 High High
Neuritis 1 75.12 Quite High
Serotonin 7 74.80 Quite High
Disease Link Frequency Relevance Heat
Stress 34 100.00 Very High Very High Very High
Congenital Myasthenic Syndromes 26 100.00 Very High Very High Very High
Pneumonia 118 99.72 Very High Very High Very High
Spinal Cord Injury 406 99.68 Very High Very High Very High
Recurrence 4 99.56 Very High Very High Very High
Demyelinating Disease 18 99.28 Very High Very High Very High
Anxiety Disorder 4 98.28 Very High Very High Very High
Death 6 93.20 High High
Bacterial Respiratory Disease 4 92.72 High High
Depression 37 91.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Minutes after dCMS, motoneuronal spontaneous activity was still substantially increased.
Positive_regulation (increased) of dCMS
1) Confidence 0.15 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2949708 Disease Relevance 0.73 Pain Relevance 0.07
The dCMS-induced effect persisted beyond the phase of stimulation and extended through the entire period of the experiment (60 min).
Positive_regulation (induced) of dCMS
2) Confidence 0.11 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2949708 Disease Relevance 0.37 Pain Relevance 0
In all animals used in these experiments, twitch force was remarkably increased after dCMS.
Positive_regulation (increased) of dCMS
3) Confidence 0.11 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2949708 Disease Relevance 0.19 Pain Relevance 0
FI was significantly increased after dCMS (Solm-Sidak post hoc, p < 0.001) in the ipsilateral side (average before = 328.53 ± 104.83 vs. average after 526.83 ± 169.38).
Positive_regulation (increased) of dCMS
4) Confidence 0.11 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2949708 Disease Relevance 0.14 Pain Relevance 0
dCMS increased spinal motoneurons spontaneous activity
Positive_regulation (increased) of dCMS in motoneurons
5) Confidence 0.11 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2949708 Disease Relevance 0.43 Pain Relevance 0.03
This indicates that injured spinal cord is more prone for dCMS stimulation and posses extra mechanisms mediating the dCMS effect.
Positive_regulation (mediating) of dCMS in spinal cord associated with spinal cord injury and spinal cord
6) Confidence 0.11 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2949708 Disease Relevance 0.20 Pain Relevance 0.12
In Figure 6F, spinal motoneuronal responses (n = 9) contralateral (to stimulated M1) showed significant increase after dCMS (average before = 347.67 ± 294.68 ?
Positive_regulation (increase) of dCMS in spinal
7) Confidence 0.10 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2949708 Disease Relevance 0.11 Pain Relevance 0
JWH015 induced variable consumption of sucrose solution in CMS and control mice (Fig. 7B).
Positive_regulation (induced) of CMS associated with stress
8) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.94 Pain Relevance 0.31
Of 14,695 potential CAP-patient visits in system B, we randomly selected 60 case-patients (i.e., those with CAP who had been tested for Coccidioides spp.) and 76 controls (i.e., those with CAP who had not been tested).
Positive_regulation (tested) of Coccidioides associated with pneumonia
9) Confidence 0.06 Published 2008 Journal Emerging Infectious Diseases Section Body Doc Link PMC2600364 Disease Relevance 0.93 Pain Relevance 0.09
Reasons that CAP patients may not be tested for Coccidioides spp. are unclear but are likely complex.
Neg (not) Positive_regulation (tested) of Coccidioides associated with pneumonia
10) Confidence 0.06 Published 2008 Journal Emerging Infectious Diseases Section Body Doc Link PMC2600364 Disease Relevance 1.42 Pain Relevance 0
To induce cytoplasmic Ca2+ transients, hESC-CMs were electrically stimulated.
Positive_regulation (stimulated) of CMs
11) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565131 Disease Relevance 0 Pain Relevance 0.03
In addition, we recently demonstrated that the CCR5+ Th1 cell subset in CSF during relapses, which significantly increased in CMS, remained low in OSMS.
Positive_regulation (increased) of CMS in CSF associated with multiple sclerosis and recurrence
12) Confidence 0.01 Published 2002 Journal Rinsho Shinkeigaku Section Abstract Doc Link 12784704 Disease Relevance 1.16 Pain Relevance 0.53
This synaptic CMS is caused by mutations in the collagenic tail subunit (ColQ) that anchors the catalytic subunits in the synaptic basal lamina.
Positive_regulation (caused) of CMS in basal lamina associated with congenital myasthenic syndromes
13) Confidence 0.01 Published 2004 Journal Rev. Neurol. (Paris) Section Abstract Doc Link 15034473 Disease Relevance 0.67 Pain Relevance 0.04
The most frequent presynaptic CMS is caused by mutations of choline acetyltransferase.
Positive_regulation (caused) of CMS associated with congenital myasthenic syndromes
14) Confidence 0.01 Published 2004 Journal Rev. Neurol. (Paris) Section Abstract Doc Link 15034473 Disease Relevance 0.63 Pain Relevance 0.04

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