INT110942

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Context Info
Confidence 0.69
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 13.69
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (TRPM8)
Anatomy Link Frequency
blood 2
stem cell 2
urine 2
skin 1
bladder 1
TRPM8 (Homo sapiens)
Pain Link Frequency Relevance Heat
member 8 13 100.00 Very High Very High Very High
Neuritis 1 99.16 Very High Very High Very High
Pain 17 98.60 Very High Very High Very High
qutenza 7 85.12 High High
Spinal cord 11 83.28 Quite High
dorsal root ganglion 32 5.00 Very Low Very Low Very Low
diabetic neuropathy 8 5.00 Very Low Very Low Very Low
Nerve growth factor 6 5.00 Very Low Very Low Very Low
sodium channel 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 43 99.68 Very High Very High Very High
Malignant Neoplastic Disease 48 99.64 Very High Very High Very High
Neuritis 1 99.16 Very High Very High Very High
Cancer 49 99.04 Very High Very High Very High
Cicatrix 1 98.80 Very High Very High Very High
Metastasis 10 98.28 Very High Very High Very High
Prostate Cancer 36 97.44 Very High Very High Very High
Neuroma 4 96.40 Very High Very High Very High
Disease 10 94.16 High High
Overactive Bladder 1 81.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We defined the sites of mRNA and protein expression of TRPM8 and TRPV1 in the rat and human genitourinary tract.
Transcription (expression) of TRPM8
1) Confidence 0.69 Published 2004 Journal J. Urol. Section Abstract Doc Link 15311065 Disease Relevance 0.08 Pain Relevance 0.09
TRPM8 mRNA was also detected in body fluids of men.
Transcription (detected) of TRPM8 in body
2) Confidence 0.68 Published 2010 Journal Int. J. Oncol. Section Abstract Doc Link 20043080 Disease Relevance 1.07 Pain Relevance 0.07
Together, these studies demonstrate that TRPM8 expression is androgen regulated in prostate cancer cells and that, while tissue TRPM8 mRNA levels can be used for detection of prostate cancer, urine and blood TRPM8 mRNA levels may prove to be useful for distinguishing metastatic disease from clinically localized prostate cancer at the time of diagnosis.
Transcription (levels) of TRPM8 in urine associated with metastasis and reprotox - general 1
3) Confidence 0.66 Published 2010 Journal Int. J. Oncol. Section Abstract Doc Link 20043080 Disease Relevance 1.12 Pain Relevance 0.05
Together, these studies demonstrate that TRPM8 expression is androgen regulated in prostate cancer cells and that, while tissue TRPM8 mRNA levels can be used for detection of prostate cancer, urine and blood TRPM8 mRNA levels may prove to be useful for distinguishing metastatic disease from clinically localized prostate cancer at the time of diagnosis.
Transcription (levels) of TRPM8 in blood associated with metastasis and reprotox - general 1
4) Confidence 0.66 Published 2010 Journal Int. J. Oncol. Section Abstract Doc Link 20043080 Disease Relevance 1.09 Pain Relevance 0
This study was designed to determine the androgen-regulation mechanisms for TRPM8 mRNA expression and to identify the phenotype of TRPM8-expressing cells in the human prostate.
Transcription (expression) of TRPM8
5) Confidence 0.53 Published 2005 Journal Endocr. Relat. Cancer Section Abstract Doc Link 15947109 Disease Relevance 0.09 Pain Relevance 0.09
These findings may contribute to design a strategy to predict prostate cancer status from the TRPM8 mRNA level.
Transcription (level) of TRPM8 associated with reprotox - general 1
6) Confidence 0.53 Published 2005 Journal Endocr. Relat. Cancer Section Abstract Doc Link 15947109 Disease Relevance 0.25 Pain Relevance 0.05
The expression of TRPM8 mRNA in the prostate was much higher than that in the bladder mucosa (3024:1), but was not found in the bladder muscle layer.
Transcription (expression) of TRPM8 in bladder
7) Confidence 0.51 Published 2008 Journal Urology Section Body Doc Link 18384850 Disease Relevance 0 Pain Relevance 0
Frequent, TRPM8-immunoreactive large calibre fibres were detected in the sub-epidermal region of hypersensitive (Fig 5G) but not hyposensitive (Fig 5H) skin.
Neg (not) Transcription (detected) of TRPM8-immunoreactive in skin
8) Confidence 0.42 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1892784 Disease Relevance 0.43 Pain Relevance 0.40
Focussing on organ confined tumors, we found a significant difference of the mRNA expression of PSA and trp-p8 between malignant and non-malignant tissue specimens.
Transcription (expression) of trp-p8 associated with malignant neoplastic disease and cancer
9) Confidence 0.41 Published 2003 Journal Int. J. Oncol. Section Abstract Doc Link 12792797 Disease Relevance 1.37 Pain Relevance 0.07
In this study, we compared the mRNA expression of recently identified prostate-associated genes, prostate stem cell antigen (PSCA) and transient receptor potential p8 (trp-p8), to the mRNA expression of the most commonly used markers for PCa, prostate-specific antigen (PSA) and human kallikrein 2 (hK2).
Transcription (expression) of trp-p8 in stem cell associated with member 8 and prostate cancer
10) Confidence 0.41 Published 2003 Journal Int. J. Oncol. Section Abstract Doc Link 12792797 Disease Relevance 0.95 Pain Relevance 0.10
In this study, we compared the mRNA expression of recently identified prostate-associated genes, prostate stem cell antigen (PSCA) and transient receptor potential p8 (trp-p8), to the mRNA expression of the most commonly used markers for PCa, prostate-specific antigen (PSA) and human kallikrein 2 (hK2).
Transcription (expression) of trp-p8 in stem cell associated with member 8 and prostate cancer
11) Confidence 0.39 Published 2003 Journal Int. J. Oncol. Section Abstract Doc Link 12792797 Disease Relevance 0.95 Pain Relevance 0.10
The highest transcript amounts were found for PSA in malignant as well as in non-malignant tissue specimens followed by hK2, trp-p8 and PSCA with an mRNA expression remarkably lower.
Transcription (expression) of trp-p8 associated with malignant neoplastic disease
12) Confidence 0.39 Published 2003 Journal Int. J. Oncol. Section Abstract Doc Link 12792797 Disease Relevance 1.35 Pain Relevance 0.08
Focussing on organ confined tumors, we found a significant difference of the mRNA expression of PSA and trp-p8 between malignant and non-malignant tissue specimens.
Transcription (expression) of trp-p8 associated with malignant neoplastic disease and cancer
13) Confidence 0.39 Published 2003 Journal Int. J. Oncol. Section Abstract Doc Link 12792797 Disease Relevance 1.37 Pain Relevance 0.07
The highest transcript amounts were found for PSA in malignant as well as in non-malignant tissue specimens followed by hK2, trp-p8 and PSCA with an mRNA expression remarkably lower.
Transcription (expression) of trp-p8 associated with malignant neoplastic disease
14) Confidence 0.39 Published 2003 Journal Int. J. Oncol. Section Abstract Doc Link 12792797 Disease Relevance 1.35 Pain Relevance 0.08
Together, these studies demonstrate that TRPM8 expression is androgen regulated in prostate cancer cells and that, while tissue TRPM8 mRNA levels can be used for detection of prostate cancer, urine and blood TRPM8 mRNA levels may prove to be useful for distinguishing metastatic disease from clinically localized prostate cancer at the time of diagnosis.
Transcription (levels) of TRPM8 in urine associated with metastasis and reprotox - general 1
15) Confidence 0.22 Published 2010 Journal Int. J. Oncol. Section Abstract Doc Link 20043080 Disease Relevance 1.09 Pain Relevance 0
Together, these studies demonstrate that TRPM8 expression is androgen regulated in prostate cancer cells and that, while tissue TRPM8 mRNA levels can be used for detection of prostate cancer, urine and blood TRPM8 mRNA levels may prove to be useful for distinguishing metastatic disease from clinically localized prostate cancer at the time of diagnosis.
Transcription (levels) of TRPM8 in blood associated with metastasis and reprotox - general 1
16) Confidence 0.22 Published 2010 Journal Int. J. Oncol. Section Abstract Doc Link 20043080 Disease Relevance 1.12 Pain Relevance 0.05

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