INT110947

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Context Info
Confidence 0.29
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.72
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (KLK2)
KLK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
member 8 1 78.00 Quite High
Pain 2 5.00 Very Low Very Low Very Low
Prostatitis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 12 99.84 Very High Very High Very High
Prostate Cancer 6 91.04 High High
Cancer 64 87.28 High High
Reprotox - General 1 40 67.96 Quite High
Benign Prostatic Hypertrophy 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The relative transcript levels of PSA, hK2 and trp-p8 were elevated in malignant in comparison to non-malignant tissues, but only for trp-p8 this increased expression was statistically significant.
Positive_regulation (elevated) of hK2 associated with malignant neoplastic disease
1) Confidence 0.29 Published 2003 Journal Int. J. Oncol. Section Abstract Doc Link 12792797 Disease Relevance 1.37 Pain Relevance 0.08
Assays for intact PSA and hK2 require greater sophistication [46,47], but are based on similar principles to the total and free PSA assays.
Positive_regulation (require) of hK2
2) Confidence 0.10 Published 2008 Journal BMC Med Section Body Doc Link PMC2474851 Disease Relevance 0.28 Pain Relevance 0
We found that, in previously unscreened men with elevated PSA, a statistical model including four markers (total PSA, free PSA, intact PSA and hK2) could predict the result of biopsy more accurately than a model incorporating total PSA and age alone.
Positive_regulation (intact) of hK2
3) Confidence 0.04 Published 2008 Journal BMC Med Section Body Doc Link PMC2474851 Disease Relevance 0.07 Pain Relevance 0

General Comments

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