INT110961

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Context Info
Confidence 0.36
First Reported 2001
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 17
Disease Relevance 6.66
Pain Relevance 2.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GYPA) molecular_function (GYPA) cellular_component (GYPA)
biological_process (GYPA)
Anatomy Link Frequency
brain 2
plasma 1
accessory cells 1
striatum 1
GYPA (Homo sapiens)
Pain Link Frequency Relevance Heat
positron emission tomography 276 99.24 Very High Very High Very High
psoriasis 1 98.28 Very High Very High Very High
Dopamine 468 97.66 Very High Very High Very High
qutenza 1 97.60 Very High Very High Very High
imagery 138 96.36 Very High Very High Very High
Spinal cord 1 80.40 Quite High
Substantia nigra 36 71.28 Quite High
monoamine 36 68.80 Quite High
chemokine 12 66.08 Quite High
cytokine 24 65.48 Quite High
Disease Link Frequency Relevance Heat
Disease 426 99.68 Very High Very High Very High
Parkinsonian Disorders 234 99.64 Very High Very High Very High
Infection 144 99.08 Very High Very High Very High
Neurodegenerative Disease 16 99.08 Very High Very High Very High
Psoriasis 1 98.28 Very High Very High Very High
Congenital Anomalies 110 97.92 Very High Very High Very High
Dilated Cardiomyopathy 1 97.28 Very High Very High Very High
Motor Neuron Diseases 5 95.04 Very High Very High Very High
Dyskinesias 1 93.60 High High
Apoptosis 1 93.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This complex organization is likely to play important roles for the discharge and recruitment properties of alpha-MNs.
MNs Spec (likely) Binding (recruitment) of
1) Confidence 0.36 Published 2003 Journal Biol Cybern Section Abstract Doc Link 12905042 Disease Relevance 0.18 Pain Relevance 0.04
The Ile58Thr amino acid exchange destabilizes the tetrameric interface of Mn-SOD and reduces its enzymatic activity [14].
Mn-SOD Binding (interface) of
2) Confidence 0.15 Published 2001 Journal BMC Med Genet Section Body Doc Link PMC31388 Disease Relevance 0.90 Pain Relevance 0.09
To determine whether nitration was related to the decline of Mn-SOD activity in the SO group, Mn-SOD nitration was evaluated following immuno-precipitation of Mn-SOD.
Mn-SOD Binding (nitration) of
3) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875392 Disease Relevance 0.15 Pain Relevance 0
To quantify Mn-SOD nitration, Mn-SOD immune complex were resolved on reducing 12.5% SDS-PAGE gels, followed by immunoblotting with primary anti-nitrotyrosine polyclonal antibody (06-284, 1?
Mn-SOD Binding (complex) of
4) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875392 Disease Relevance 0 Pain Relevance 0
Nitration of Mn-SOD was digitally quantified as aforementioned.


Mn-SOD Binding (Nitration) of
5) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875392 Disease Relevance 0 Pain Relevance 0
To quantify Mn-SOD nitration, Mn-SOD immune complex were resolved on reducing 12.5% SDS-PAGE gels, followed by immunoblotting with primary anti-nitrotyrosine polyclonal antibody (06-284, 1?
Mn-SOD Binding (nitration) of
6) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2875392 Disease Relevance 0 Pain Relevance 0
Taking all of the information together, the most parsimonious explanation is that the parkinsonism in these welders was not likely associated with the Mn in the welding fumes.
Mn Binding (associated) of associated with parkinsonian disorders
7) Confidence 0.13 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.82 Pain Relevance 0.17
A much more limited number of SPECT or PET studies are available for conditions associated with Mn-induced parkinsonism.
Mn Binding (associated) of associated with positron emission tomography and parkinsonian disorders
8) Confidence 0.10 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.80 Pain Relevance 0.47
Most of the neuropathological studies associated with occupational Mn exposures were performed in the early 1900s and lacked detailed examination of brain tissue.
Mn Binding (associated) of in brain
9) Confidence 0.10 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.63 Pain Relevance 0.10
In summary, the evidence from neuroimaging studies have indicated that in different human conditions where Mn concentrations markedly increase in the brain to produce movement abnormalities, there is a lack of degeneration of the nigrostriatal dopaminergic terminals.


Mn Binding (concentrations) of in brain associated with congenital anomalies
10) Confidence 0.10 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.87 Pain Relevance 0.03
In PD and conditions associated with Mn-induced parkinsonism, three principal neuroimaging modalities have been used: T1-weighted MRI, SPECT, and PET.
Mn Binding (associated) of associated with positron emission tomography, parkinsonian disorders, disease and imagery
11) Confidence 0.10 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 1.11 Pain Relevance 0.30
However, a firm conclusion that chronic Mn results in the loss of DAT and presumably dopamine neuron terminals in the striatum cannot be made because [11C]-nomifensine is not a selective DAT ligand and because Mn can directly inhibit ligand binding to DAT.
Mn Binding (binding) of in striatum associated with dopamine
12) Confidence 0.10 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0 Pain Relevance 0.63
Therefore, it is not surprising that we did not detect MIV-150 in the plasma after repeated application of gels containing 50 ┬ÁM MIV-150, but did detect it in the cervico-vaginal fluids and associated with the tissues.
MIV-150 Binding (associated) of in plasma
13) Confidence 0.03 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016413 Disease Relevance 0.37 Pain Relevance 0.07
More MIV-150 was associated with cervical tissue 8 h after daily dosing of MIV-150/zinc acetate versus MIV-150, while comparable MIV-150 levels were associated with vaginal tissues and at 24 h.


MIV-150 Binding (associated) of
14) Confidence 0.03 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3016413 Disease Relevance 0.41 Pain Relevance 0
Rather, the level of MIV-150 associated with the cervical tissues appears to be a better predictor of efficacy.
MIV-150 Binding (associated) of
15) Confidence 0.03 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3016413 Disease Relevance 0.15 Pain Relevance 0
This recombinant protein binds CD2 on T cells and Fc gamma RIII on accessory cells (e.g., natural killer cells, macrophages), inhibiting T cell activation/proliferation and inducing selective T cell apoptosis.
recombinant protein Binding (binds) of in accessory cells associated with apoptosis
16) Confidence 0.01 Published 2002 Journal J Pharmacokinet Pharmacodyn Section Abstract Doc Link 12795239 Disease Relevance 0.19 Pain Relevance 0.05
The purified recombinant protein bound ca. 2 mol of copper/mol of protein.
recombinant protein Binding (bound) of
17) Confidence 0.00 Published 2008 Journal Biochemistry Section Abstract Doc Link 19055324 Disease Relevance 0.09 Pain Relevance 0.10

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