INT11098

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Context Info
Confidence 0.37
First Reported 1987
Last Reported 2008
Negated 2
Speculated 2
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 1.39
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (NPR1)
Anatomy Link Frequency
plasma 2
esophageal sphincter 1
outflow 1
coronary artery 1
smooth muscle 1
NPR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opiate 4 100.00 Very High Very High Very High
Catecholamine 2 100.00 Very High Very High Very High
narcan 7 99.84 Very High Very High Very High
Calcium channel 1 98.36 Very High Very High Very High
halothane 2 97.88 Very High Very High Very High
tetrodotoxin 4 91.68 High High
Endogenous opioid 2 88.32 High High
adenocard 1 83.72 Quite High
anesthesia 1 78.00 Quite High
Angina 4 77.44 Quite High
Disease Link Frequency Relevance Heat
Natriuresis 14 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 1 84.20 Quite High
Increased Venous Pressure Under Development 1 81.72 Quite High
Cv General 3 Under Development 4 77.44 Quite High
Diuresis 4 75.00 Quite High
Heart Rate Under Development 1 50.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compared to the time control study, naloxone had no effects on mean arterial pressure (MAP), plasma renin activity (PRA), aldosterone, catecholamines, atrial natriuretic peptide (ANP), glomerular filtration rate (GFR), estimated renal plasma flow (ERPF), and sodium excretion.
Neg (no) Regulation (effects) of atrial natriuretic peptide in plasma associated with natriuresis, catecholamine and narcan
1) Confidence 0.37 Published 1995 Journal Kidney Int. Section Abstract Doc Link 7474676 Disease Relevance 0.35 Pain Relevance 0.39
Moreover, neither the L-type calcium channel blocker nicardipine, NO synthase inhibitor l-N(G)-nitroarginine methyl ester nor guanylate cyclase activator guanylin affected the spontaneous 5-HT outflow.
Neg (neither) Regulation (affected) of guanylate cyclase in outflow associated with calcium channel
2) Confidence 0.35 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17022966 Disease Relevance 0 Pain Relevance 0.26
Basal activity of platelet guanylate cyclase and its response to sodium nitroprusside were not affected after administration of NTG.
Regulation (response) of platelet guanylate cyclase in platelet
3) Confidence 0.27 Published 1997 Journal Am. J. Cardiol. Section Abstract Doc Link 9230146 Disease Relevance 0.31 Pain Relevance 0.46
This study investigates the perioperative role of atrial natriuretic peptide, renin, angiotensin, aldosterone, and vasopressin in patient response to cardiopulmonary bypass after coronary artery bypass operations.
Spec (investigates) Regulation (role) of atrial natriuretic peptide in coronary artery associated with natriuresis
4) Confidence 0.25 Published 1992 Journal J. Thorac. Cardiovasc. Surg. Section Abstract Doc Link 1534591 Disease Relevance 0.54 Pain Relevance 0.08
Effect of opiate, general anaesthesia and surgery on plasma atrial natriuretic peptide levels in man.
Regulation (Effect) of atrial natriuretic peptide in plasma associated with natriuresis and opiate
5) Confidence 0.20 Published 1987 Journal Clin. Exp. Pharmacol. Physiol. Section Title Doc Link 2964965 Disease Relevance 0.19 Pain Relevance 0.42
The purpose of this study was to determine the effect of the enzyme soluble guanylate cyclase (cGC) inhibitors, cystamine (100 microM), methylene blue (30 microM), LY 83583 (6-anilino-5,8 quinoledione, 10 microM) and ODQ (H-[1,2,4]oxadiazolo[4,3]quinoxalin-1-one, 1 microM) on the relaxations induced by EFS and by exogenous NO (nitric oxide, 0.5 mM) or NO-donors on SA opossum LES smooth muscle strips.
Spec (determine) Regulation (effect) of guanylate cyclase in smooth muscle
6) Confidence 0.01 Published 2008 Journal Fundam Clin Pharmacol Section Abstract Doc Link 18485148 Disease Relevance 0 Pain Relevance 0.07
The effect of guanylate cyclase inhibitors on non-adrenergic and non-cholinergic neurogenic relaxations of the South American opossum lower esophageal sphincter.
Regulation (effect) of guanylate cyclase in esophageal sphincter
7) Confidence 0.01 Published 2008 Journal Fundam Clin Pharmacol Section Title Doc Link 18485148 Disease Relevance 0 Pain Relevance 0.06

General Comments

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