INT110980

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Context Info
Confidence 0.45
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 8.02
Pain Relevance 2.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CTSB) mitochondrion (CTSB) extracellular space (CTSB)
extracellular region (CTSB) intracellular (CTSB) lysosome (CTSB)
Anatomy Link Frequency
cleavage 2
vesicle 2
endothelial cells 1
pancreas 1
CTSB (Homo sapiens)
Pain Link Frequency Relevance Heat
Abeta 7 100.00 Very High Very High Very High
metalloproteinase 13 99.10 Very High Very High Very High
cytokine 36 98.64 Very High Very High Very High
rheumatoid arthritis 121 98.22 Very High Very High Very High
Neuropeptide 3 96.64 Very High Very High Very High
Neurotransmitter 6 95.68 Very High Very High Very High
Opioid 2 94.68 High High
Enkephalin 3 94.40 High High
Chronic pancreatitis 9 93.44 High High
cINOD 25 93.16 High High
Disease Link Frequency Relevance Heat
Death 40 100.00 Very High Very High Very High
Alzheimer's Dementia 32 99.64 Very High Very High Very High
Apoptosis 30 99.00 Very High Very High Very High
Pancreatitis 69 98.52 Very High Very High Very High
Neurodegenerative Disease 20 98.48 Very High Very High Very High
Rheumatoid Arthritis 121 98.22 Very High Very High Very High
Targeted Disruption 59 96.60 Very High Very High Very High
Toxicity 19 93.76 High High
Fibrosis 13 93.72 High High
Coagulation Disorder 1 93.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At pH 3.8, the cathepsin B cleavage of pWT and pK23R was less than at pH 5, whereas the cleavage of pD22G was completely inhibited (figure 1).
Gene_expression (cleavage) of cathepsin B in cleavage
1) Confidence 0.45 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC117221 Disease Relevance 0.18 Pain Relevance 0
A recent study showed that cathepsin B is abundantly present in the secretory compartment of the healthy human pancreas and is secreted together with trypsinogen and active trypsin into the pancreatic juice of patients with chronic pancreatitis [8].
Gene_expression (present) of cathepsin B in pancreas associated with chronic pancreatitis
2) Confidence 0.45 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC117221 Disease Relevance 0.53 Pain Relevance 0.15
However, our investigations on the cleavability of the trypsinogen activation bond bond by active trypsin [3] and cathepsin B provide further evidence, that autoactivation rather than cathepsin B mediated trypsinogen activation is the key pathogenic event in the development of hereditary pancreatitis in D22G and K23R-carriers.
Gene_expression (cleavability) of cathepsin B associated with pancreatitis
3) Confidence 0.45 Published 2002 Journal BMC Gastroenterol Section Body Doc Link PMC117221 Disease Relevance 0.61 Pain Relevance 0.07
Unique neuronal functions of cathepsin L and cathepsin B in secretory vesicles: biosynthesis of peptides in neurotransmission and neurodegenerative disease.
Gene_expression (biosynthesis) of cathepsin B in vesicles associated with neurodegenerative disease
4) Confidence 0.14 Published 2006 Journal Biol. Chem. Section Title Doc Link 17081116 Disease Relevance 0.41 Pain Relevance 0.33
Immunohistochemistry showed that the areas of increased myofibroblastic activity were positive for vimentin, desmin and b-cathepsin.
Gene_expression (positive) of b-cathepsin
5) Confidence 0.14 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2615039 Disease Relevance 1.11 Pain Relevance 0.09
In early RA the mRNAs for matrix metalloproteinase (MMP)-1 (collagenase) and the cysteine proteases cathepsin B and cathepsin L are expressed by synovial endothelial cells, as shown by in situ hybridisation [120].
Gene_expression (expressed) of cathepsin B in endothelial cells associated with metalloproteinase and rheumatoid arthritis
6) Confidence 0.06 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 0.66 Pain Relevance 0.57
-secretase, one of the enzymes that cleaves APP, which could probably be the underlying mechanism of the A?
Gene_expression (one) of secretase
7) Confidence 0.06 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915753 Disease Relevance 0.68 Pain Relevance 0.14
Synthesis of the major APPs can be increased up to 1000-fold over normal levels under acute-phase conditions.
Gene_expression (Synthesis) of APPs
8) Confidence 0.05 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2977073 Disease Relevance 0.57 Pain Relevance 0.10
The genes TPT1 (or histamine releasing factor), cytokine induced apoptosis inhibitor 1 (cIAP-1), mitochondrial PUMA (BBC3), cathepsin B (CTSB), ATP6V0A1, cathepsin L and LAMP2, all of which are associated with cell-death related responses, were differentially expressed after the 1 h exposure to L. plantarum WCFS1.
Gene_expression (expressed) of cathepsin B associated with apoptosis, death and cytokine
9) Confidence 0.04 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.61 Pain Relevance 0.14
-secretase which acts on the APP are currently being synthesized [45-47].
Gene_expression (synthesized) of secretase
10) Confidence 0.03 Published 2009 Journal The Open Neurology Journal Section Body Doc Link PMC2684708 Disease Relevance 0.83 Pain Relevance 0.03
Furthermore, new results using these strategies have identified secretory vesicle cathepsin B for the production of beta-amyloid (Abeta) in the major regulated secretory pathway that provides activity-dependent secretion of Abeta peptides, which accumulate in AD. 3.
Gene_expression (production) of cathepsin B in vesicle associated with alzheimer's dementia and abeta
11) Confidence 0.02 Published 2006 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 16724274 Disease Relevance 0.48 Pain Relevance 0.42
Production of the gamma-secretase-generated intracellular domain (ICD) occurs more rapidly from APLP1 than from either APLP2 or APP, suggesting that APLP1 is a better gamma-substrate and that substrate recognition is not restricted to the highly conserved amino acid sequences surrounding the epsilon-site.
Gene_expression (Production) of gamma-secretase
12) Confidence 0.02 Published 2009 Journal Biochemistry Section Abstract Doc Link 19821615 Disease Relevance 0.35 Pain Relevance 0.07
These compounds seem to target the gamma-secretase complex, increasing gamma-secretase-catalyzed production of Abeta42 in vitro.
Gene_expression (production) of gamma-secretase
13) Confidence 0.02 Published 2005 Journal Nat. Med. Section Abstract Doc Link 15834426 Disease Relevance 0.31 Pain Relevance 0.27
-bonded cyclopentadienyl (Cpa) aAbbreviations: AAS, atomic absorption spectrometry; acac, acetylacetonato; bip, biphenyl; BNCT, boron neutron capture therapy; BSA, bovine serum albumin; Cat B, cathepsin B; CDK, cyclin-dependent kinase; cGMP, 3?
Gene_expression (cathepsin B) of cathepsin B
14) Confidence 0.01 Published 2010 Journal Journal of Medicinal Chemistry Section Body Doc Link PMC3018145 Disease Relevance 0 Pain Relevance 0
Several mechanisms could explain the production of multiple Abeta peptides by gamma-secretase, including sequential processing of longer into shorter Abeta peptides.
Gene_expression (production) of gamma-secretase associated with abeta
15) Confidence 0.01 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18426795 Disease Relevance 0.35 Pain Relevance 0.27
To determine the possible function(s) of the B. malayi cathepsin-like cysteine protease genes during embryogenesis of B. malayi, RNAi was carried out to selectively interfere with Bm cathepsin-like cysteine protease gene expression; Bm-cpz or Bm-cpl.
Gene_expression (expression) of cysteine protease
16) Confidence 0.01 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2634747 Disease Relevance 0.35 Pain Relevance 0
However, it is notable that production of catestatin itself (CgA(344)(-)(364)) utilizes more unusual cleavage sites at the NH(2)-terminal sides of downward arrow R and downward arrow RR basic residue sites, consistent with the cleavage specificities of the chromaffin granule cysteine protease "PTP" that participates in proenkephalin processing.
Gene_expression (production) of chromaffin granule cysteine protease in cleavage
17) Confidence 0.01 Published 2003 Journal Biochemistry Section Abstract Doc Link 12795588 Disease Relevance 0 Pain Relevance 0.04

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