INT110987

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Context Info
Confidence 0.71
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 45
Total Number 46
Disease Relevance 24.16
Pain Relevance 6.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ESR1) enzyme binding (ESR1) DNA binding (ESR1)
protein complex (ESR1) cytoplasm (ESR1) signal transduction (ESR1)
Anatomy Link Frequency
adipose tissue 6
adipocyte 4
fat 2
hypothalamus 1
endometrium 1
ESR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 11 99.36 Very High Very High Very High
Catecholamine 119 98.68 Very High Very High Very High
noradrenaline 85 98.28 Very High Very High Very High
agonist 291 98.16 Very High Very High Very High
Opioid 125 97.44 Very High Very High Very High
endometriosis 7 96.80 Very High Very High Very High
Pain 70 96.44 Very High Very High Very High
tolerance 2 94.60 High High
Clonidine 34 93.20 High High
cocaine 84 91.12 High High
Disease Link Frequency Relevance Heat
Obesity 2237 99.98 Very High Very High Very High
Stress 89 99.96 Very High Very High Very High
Cancer 224 99.68 Very High Very High Very High
Endometriosis (extended) 34 99.18 Very High Very High Very High
Endometriosis 13 99.16 Very High Very High Very High
Apoptosis 279 99.04 Very High Very High Very High
Dilated Cardiomyopathy 2 98.88 Very High Very High Very High
Drug Induced Neurotoxicity 95 96.92 Very High Very High Very High
Pain 85 96.44 Very High Very High Very High
Uterine Fibroids 72 92.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Low ESR1 mRNA levels in adipose tissue may counteract catecholamine resistance in fat cells of obese women hereby contributing to loss of sc and gain of visceral fat [39].
Transcription (levels) of ESR1 in fat associated with catecholamine and obesity
1) Confidence 0.71 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2238734 Disease Relevance 1.39 Pain Relevance 0.23
In multiple regression, including BMI, age, and ESR1 mRNA levels as independent variables, ESR1 levels were an independent factor regulating basal lipolysis (P = 0.018), as well as responsiveness to noradrenaline (P = 0.013), Table 5.
Transcription (levels) of ESR1 associated with obesity and noradrenaline
2) Confidence 0.69 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2238734 Disease Relevance 0.65 Pain Relevance 0.33
In multiple regression, including BMI, age, and ESR1 mRNA levels as independent variables, ESR1 levels were an independent factor regulating basal lipolysis (P = 0.018), as well as responsiveness to noradrenaline (P = 0.013), Table 5.
Transcription (levels) of ESR1 associated with obesity and noradrenaline
3) Confidence 0.69 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2238734 Disease Relevance 0.60 Pain Relevance 0.33
In 122 women with a large variation in BMI, part of sample 3, there was an inverse correlation between ESR1 mRNA levels in abdominal sc adipose tissue and adipocyte basal lipolysis as well as responsiveness to noradrenaline and more selective adrenoceptor agonists, Figure 3.
Transcription (levels) of ESR1 in adipose tissue associated with obesity, agonist and noradrenaline
4) Confidence 0.69 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2238734 Disease Relevance 0.76 Pain Relevance 0.25
Association between ESR1 mRNA levels and lipolytic responsiveness was stronger for the ?
Transcription (levels) of ESR1
5) Confidence 0.69 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2238734 Disease Relevance 0.51 Pain Relevance 0.36
Relation of ESR1 SNPs and mRNA levels to adipocyte lipolysis and lipogenesis phenotypes
Transcription (levels) of ESR1 in adipocyte
6) Confidence 0.69 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2238734 Disease Relevance 0.83 Pain Relevance 0.11
ERalpha mRNA levels were similar in the endometriotic implants/eutopic endometrium from women with endometriosis and in normal tissue (P = 0.649).
Transcription (levels) of ERalpha in endometrium associated with endometriosis
7) Confidence 0.67 Published 2009 Journal J. Mol. Histol. Section Abstract Doc Link 19199093 Disease Relevance 1.20 Pain Relevance 0.32
Estrogen receptor alpha nuclear/cytosol distribution
Transcription (distribution) of Estrogen receptor
8) Confidence 0.64 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.09 Pain Relevance 0
-target genes, we examined the steady-state mRNA level of ER?
Spec (examined) Transcription (level) of ER
9) Confidence 0.64 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0 Pain Relevance 0
The apoptotic events were associated not only with increased abundance of ER?
Transcription (abundance) of ER associated with apoptosis
10) Confidence 0.64 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.57 Pain Relevance 0
Oxymorphone ER should be prescribed every 12 hours.
Transcription (prescribed) of Oxymorphone ER
11) Confidence 0.60 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621383 Disease Relevance 0.16 Pain Relevance 1.51
To date, no quantitative method, such as real-time PCR, has been clinically implicated as being able to detect mRNA levels of ESR1 (the gene encoding for the ER?)
Transcription (levels) of ESR1
12) Confidence 0.54 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2235910 Disease Relevance 0.33 Pain Relevance 0
To date, no quantitative method, such as real-time PCR, has been clinically implicated as being able to detect mRNA levels of ESR1 (the gene encoding for the ER?)
Transcription (detect) of ESR1
13) Confidence 0.54 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2235910 Disease Relevance 0.33 Pain Relevance 0
The inverse correlation between ESR1 mRNA levels and lipolytic responsiveness to adrenoceptor agonists implies that low adipose tissue ESR1 levels attenuate catecholamine resistance in sc fat cells of obese women hereby contributing to loss of sc and gain of visceral fat.
Transcription (levels) of ESR1 in fat associated with catecholamine, obesity and agonist
14) Confidence 0.53 Published 2007 Journal BMC Med Genet Section Abstract Doc Link PMC2238734 Disease Relevance 1.00 Pain Relevance 0.22
There was an inverse correlation between ESR1 mRNA levels in abdominal subcutaneous (sc) adipose tissue and basal lipolysis, as well as responsiveness to adrenoceptor agonists independent of age and BMI (P value 0.009–0.045).
Transcription (levels) of ESR1 in adipose tissue associated with obesity and agonist
15) Confidence 0.53 Published 2007 Journal BMC Med Genet Section Abstract Doc Link PMC2238734 Disease Relevance 1.14 Pain Relevance 0.12
We have recently reported that ESR1 mRNA expression levels in sc adipose tissue and isolated adipocytes from premenopausal women are inversely correlated with BMI [16].
Transcription (levels) of ESR1 in adipose tissue associated with obesity
16) Confidence 0.53 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2238734 Disease Relevance 1.27 Pain Relevance 0
ESR1 mRNA levels in adipose tissue were quantified in the 122 women of sample 3 for which RNA was available. 99 women in sample 3 who met the criteria for obesity in sample 1 were included in both samples.
Transcription (levels) of ESR1 in adipose tissue associated with obesity
17) Confidence 0.53 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2238734 Disease Relevance 1.49 Pain Relevance 0
Impact of estrogen receptor gene polymorphisms and mRNA levels on obesity and lipolysis – a cohort study

Background

Transcription (levels) of estrogen receptor associated with obesity
18) Confidence 0.53 Published 2007 Journal BMC Med Genet Section Title Doc Link PMC2238734 Disease Relevance 0.79 Pain Relevance 0
We have recently reported that ESR1 mRNA expression levels in sc adipose tissue and isolated adipocytes from premenopausal women are inversely correlated with BMI [16].
Transcription (expression) of ESR1 in adipose tissue associated with obesity
19) Confidence 0.53 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2238734 Disease Relevance 1.26 Pain Relevance 0
We also relate adipose tissue ESR1 mRNA levels and ESR1 SNPs to adipocyte lipolysis and lipogenesis phenotypes.


Transcription (levels) of ESR1 in adipocyte associated with obesity
20) Confidence 0.53 Published 2007 Journal BMC Med Genet Section Abstract Doc Link PMC2238734 Disease Relevance 0.57 Pain Relevance 0

General Comments

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