INT110988

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Context Info
Confidence 0.42
First Reported 2002
Last Reported 2010
Negated 4
Speculated 6
Reported most in Body
Documents 58
Total Number 65
Disease Relevance 42.12
Pain Relevance 12.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Insr) endosome (Insr) plasma membrane (Insr)
nucleus (Insr) kinase activity (Insr)
Anatomy Link Frequency
macrophages 4
liver 4
blood 4
Plasma 3
fat 3
Insr (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 48 100.00 Very High Very High Very High
metalloproteinase 708 99.94 Very High Very High Very High
cINOD 75 99.90 Very High Very High Very High
chemokine 90 99.60 Very High Very High Very High
cytokine 269 99.00 Very High Very High Very High
Opioid 69 98.96 Very High Very High Very High
Central nervous system 44 98.38 Very High Very High Very High
tolerance 248 98.30 Very High Very High Very High
Dismenorea 9 97.80 Very High Very High Very High
Inflammatory response 67 97.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 2984 100.00 Very High Very High Very High
Insulin Resistance 902 100.00 Very High Very High Very High
Apoptosis 475 100.00 Very High Very High Very High
Targeted Disruption 143 100.00 Very High Very High Very High
Weight Gain 28 100.00 Very High Very High Very High
Glioma 39 99.86 Very High Very High Very High
Cancer 718 99.80 Very High Very High Very High
INFLAMMATION 894 99.62 Very High Very High Very High
Disorder Of Lipid Metabolism 75 99.28 Very High Very High Very High
Colon Cancer 27 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This analysis revealed a significant decrease in basal hepatic glucose production in IR?
Gene_expression (production) of IR
1) Confidence 0.42 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.59 Pain Relevance 0.10
To address whether the observed reduction in systemic, obesity- associated inflammatory response correlates with alterations of the local, obesity-associated infiltration of adipose tissue by macrophages, we next analyzed the expression of F4/80, a specific marker for this cell-type, in WAT of control- and IR?
Spec (analyzed) Gene_expression (expression) of IR in macrophages associated with inflammatory response and obesity
2) Confidence 0.42 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.27 Pain Relevance 0.23
Insulin receptor–deficient macrophages exhibit increased susceptibility to lipid-induced apoptosis and reduced expression of matrix metalloproteinase 9
Gene_expression (expression) of Insulin receptor in macrophages associated with metalloproteinase and apoptosis
3) Confidence 0.41 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.24 Pain Relevance 0.23
To address the role of myeloid cell insulin action on whole body glucose metabolism, we next determined blood glucose and serum insulin concentrations in control- and IR?
Spec (determined) Gene_expression (concentrations) of IR in body
4) Confidence 0.36 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.57 Pain Relevance 0.03
Glucose and insulin levels did also rise in obese IR?
Gene_expression (obese) of IR associated with obesity
5) Confidence 0.36 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.62 Pain Relevance 0.10
and IL-6 was reduced in skeletal muscle, but not liver of obese IR?
Neg (not) Gene_expression (liver) of IR in liver associated with obesity
6) Confidence 0.36 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.89 Pain Relevance 0.24
When exposed to high fat diet (HFD), control-mice significantly gained weight over animals exposed to NCD, and the degree of weight gain was similar between control- and IR?
Gene_expression (exposed) of IR in fat associated with weight gain
7) Confidence 0.36 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.04 Pain Relevance 0.03
This analysis revealed, that basal JNK activity, as assessed by phosphorylation of c-Jun, was significantly reduced in skeletal muscle and exhibited a trend towards reduction in liver of obese IR?
Gene_expression (liver) of IR in liver associated with obesity
8) Confidence 0.36 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.78 Pain Relevance 0.25
Glucose and insulin levels did also rise in obese IR?
Gene_expression (rise) of IR associated with obesity
9) Confidence 0.36 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.62 Pain Relevance 0.10
While HFD induced a highly significant increase of circulating MMP-9 in control animals, this increase was less profound in IR?
Gene_expression (profound) of IR associated with metalloproteinase
10) Confidence 0.36 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.43 Pain Relevance 0.53
and IL-6 was reduced in skeletal muscle, but not liver of obese IR?
Neg (not) Gene_expression (obese) of IR in liver associated with obesity
11) Confidence 0.36 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.89 Pain Relevance 0.24
Importantly, IR disruption in macrophages not only affected MMP-9 expression, but also translated into reduced MMP-9 activity.
Gene_expression (disruption) of IR in macrophages associated with metalloproteinase
12) Confidence 0.36 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.34 Pain Relevance 0.49
Another question is why reduced macrophage accumulation in obese IR?
Gene_expression (obese) of IR in macrophage associated with obesity
13) Confidence 0.36 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.24 Pain Relevance 0.04
No difference was observable in adipocyte morphology or adipocyte size distribution between control- and IR?
Spec (observable) Gene_expression (observable) of IR in adipocyte
14) Confidence 0.36 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.09 Pain Relevance 0.03
Furthermore, we performed histological analyses of WAT obtained from obese control- and IR?
Spec (analyses) Gene_expression (analyses) of IR associated with obesity
15) Confidence 0.36 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.14 Pain Relevance 0.03
This decrease appeared to represent reduced macrophage recruitment, since bone marrow-derived macrophages (BMDM) of IR?
Gene_expression (macrophages) of IR in bone marrow
16) Confidence 0.36 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.18 Pain Relevance 0.13
To verify the in vivo relevance of this cell-autonomous impairment in MMP-9 expression and activation, we first determined serum MMP-9 concentrations in lean and obese control and IR?
Spec (determined) Gene_expression (concentrations) of IR associated with obesity and metalloproteinase
17) Confidence 0.36 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.40 Pain Relevance 0.55
Furthermore, IR?
Gene_expression (Furthermore) of IR
18) Confidence 0.36 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2865520 Disease Relevance 1.48 Pain Relevance 0.25
However, we could not observe increased macrophage apoptosis in adipose tissue or altered numbers of circulating monocytes in obese IR?
Gene_expression (obese) of IR in monocytes associated with obesity and apoptosis
19) Confidence 0.36 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.08 Pain Relevance 0.14
This analysis revealed, that basal JNK activity, as assessed by phosphorylation of c-Jun, was significantly reduced in skeletal muscle and exhibited a trend towards reduction in liver of obese IR?
Gene_expression (obese) of IR in liver associated with obesity
20) Confidence 0.36 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.78 Pain Relevance 0.25

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