INT110992

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Context Info
Confidence 0.50
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.01
Pain Relevance 1.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (TGFB1) enzyme binding (TGFB1) embryo development (TGFB1)
cytoplasm (TGFB1) extracellular space (TGFB1) extracellular region (TGFB1)
Anatomy Link Frequency
PSC 2
TGFB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 11 100.00 Very High Very High Very High
fibrosis 9 100.00 Very High Very High Very High
Chronic pancreatitis 33 99.60 Very High Very High Very High
cytokine 38 94.64 High High
Inflammation 19 75.00 Quite High
Pain 4 63.56 Quite High
nociceptor 1 61.48 Quite High
ischemia 7 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 22 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 83 99.84 Very High Very High Very High
Pancreatitis 33 99.60 Very High Very High Very High
Wound Healing 1 98.20 Very High Very High Very High
Injury 37 85.96 High High
Cirrhosis 10 80.96 Quite High
Sepsis 15 79.68 Quite High
INFLAMMATION 20 75.00 Quite High
Apoptosis 3 68.60 Quite High
Pancreatic Cancer 1 65.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the findings could also support a proatherogenic role of TGF-beta(1) resulting from the overexpression of LDL-binding proteoglycans.


Positive_regulation (role) of Positive_regulation (resulting) of TGF-beta
1) Confidence 0.50 Published 2003 Journal Cardiovasc. Res. Section Body Doc Link 12798441 Disease Relevance 0.11 Pain Relevance 0
In addition, donor and CP PBMC significantly induced an increase in IL-6, MCP-1 and TGFbeta levels under coculture conditions.
Positive_regulation (induced) of Positive_regulation (increase) of TGFbeta associated with chronic pancreatitis
2) Confidence 0.28 Published 2007 Journal J Transl Med Section Abstract Doc Link PMC2234395 Disease Relevance 1.56 Pain Relevance 0.84
We conclude that under conditions of upregulated TGF-beta, like fibrosis, NGF levels will also increase in PSC which might contribute to pancreatic wound healing responses.
Positive_regulation (increase) of Positive_regulation (upregulated) of TGF-beta in PSC associated with fibrosis, nerve growth factor, wound healing and primary sclerosing cholangitis
3) Confidence 0.09 Published 2009 Journal Growth Factors Section Abstract Doc Link 19639490 Disease Relevance 1.19 Pain Relevance 0.66
However, consistent with the array results, there was a 2-fold increase in LIF and a 4-fold increase in TGFß1 (Table 1).
Positive_regulation (increase) of Positive_regulation (increase) of TGF
4) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832687 Disease Relevance 0.15 Pain Relevance 0

General Comments

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