INT11100

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Context Info
Confidence 0.37
First Reported 1992
Last Reported 1993
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.49
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (NPR1)
Anatomy Link Frequency
spinal cord 2
NPR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 5 100.00 Very High Very High Very High
Thermal hyperalgesia 2 99.04 Very High Very High Very High
Lasting pain 2 97.72 Very High Very High Very High
nMDA receptor 2 96.76 Very High Very High Very High
anesthesia 1 95.60 Very High Very High Very High
withdrawal 1 95.20 Very High Very High Very High
Neurotransmitter 1 87.92 High High
Pain 1 81.36 Quite High
analgesia 1 80.64 Quite High
nociceptor 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Natriuresis 9 100.00 Very High Very High Very High
Hyperalgesia 2 99.04 Very High Very High Very High
Pain 3 97.28 Very High Very High Very High
Heart Rate Under Development 1 88.16 High High
Nociception 3 86.64 High High
Diuresis 4 84.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum levels of atrial natriuretic peptide were found to be significantly elevated immediately after discontinuation of cardiopulmonary bypass.
Positive_regulation (elevated) of Gene_expression (levels) of atrial natriuretic peptide associated with natriuresis
1) Confidence 0.37 Published 1992 Journal J. Thorac. Cardiovasc. Surg. Section Abstract Doc Link 1534591 Disease Relevance 0.90 Pain Relevance 0.10
Collectively, these reports suggest that the reflex withdrawal response to noxious heat is not mediated through activation of NMDA receptors and subsequent production of NO and cGMP, but that the acute NMDA-produced facilitation of thermal reflexes is NMDA-, NO- and cGMP-mediated and that a sustained production of NO and subsequent activation of soluble guanylate cyclase (GC-S) in the lumbar spinal cord appears to be required for maintenance of the thermal hyperalgesia produced in persistent pain models.
Spec (appears) Positive_regulation (required) of Gene_expression (production) of cyclase in spinal cord associated with pain, lasting pain, thermal hyperalgesia, nmda receptor, withdrawal and spinal cord
2) Confidence 0.01 Published 1993 Journal Pain Section Abstract Doc Link 8455960 Disease Relevance 0.59 Pain Relevance 0.89

General Comments

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