INT11101

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Context Info
Confidence 0.61
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.43
Pain Relevance 3.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Lbp) transport (Lbp) extracellular space (Lbp)
extracellular region (Lbp)
Anatomy Link Frequency
macrophages 3
facet 2
leg 2
monocytes 1
Lbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
backache 30 100.00 Very High Very High Very High
Pain 19 100.00 Very High Very High Very High
chemokine 4 100.00 Very High Very High Very High
Facet joint 3 89.12 High High
Inflammation 63 82.16 Quite High
local anesthetic 1 66.24 Quite High
cytokine 16 26.16 Quite Low
metalloproteinase 16 25.04 Quite Low
spinal stenosis 1 22.28 Low Low
rheumatoid arthritis 80 13.96 Low Low
Disease Link Frequency Relevance Heat
Low Back Pain 32 100.00 Very High Very High Very High
Pain 17 100.00 Very High Very High Very High
Repression 2 99.80 Very High Very High Very High
Sepsis 75 98.36 Very High Very High Very High
Systemic Inflammatory Response Syndrome 30 94.12 High High
Bacteremia 4 86.48 High High
INFLAMMATION 71 82.16 Quite High
Infection 34 77.96 Quite High
Syndrome 2 77.28 Quite High
Osteomyelitis 2 73.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results suggest that sociocultural factors influence the expression of LBP, but not the risk of chronicity once LBP is reported, and that work satisfaction may not be causally related to LBP, but may intervene along with type of occupation in the possibility of continuing employment once LBP is present.
Neg (not) Regulation (influence) of Gene_expression (expression) of LBP associated with backache
1) Confidence 0.61 Published 1994 Journal Spine Section Abstract Doc Link 8153818 Disease Relevance 1.48 Pain Relevance 1.48
The literature, however, fails to conclusively document the role of the facet in the production of LBP.
Regulation (role) of Gene_expression (production) of LBP in facet associated with backache
2) Confidence 0.61 Published 1992 Journal Clin. Orthop. Relat. Res. Section Abstract Doc Link 1534721 Disease Relevance 0.73 Pain Relevance 0.76
Separate ratings will be collected for LBP and leg pain.
Regulation (collected) of Gene_expression (pain) of LBP in leg associated with pain
3) Confidence 0.40 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2874768 Disease Relevance 0.86 Pain Relevance 0.86
An attractive hypothesis for WAY-169916-mediated activity in the spleen involves the downregulation of LBP and CD14 expression on monocytes and macrophages, resulting in a diminished immune response and ultimately resulting in the observed decreases in MMP9, IL1R2, chemokine-like factor 1, S100A8, and S100A9 through the repression of NF-?
Regulation (through) of Gene_expression (expression) of LBP in macrophages associated with chemokine and repression
4) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174937 Disease Relevance 0.39 Pain Relevance 0.19
Differences in levels of HMGB1, LBP, IL6 and CRP between children with and without bacteraemia
Regulation (Differences) of Gene_expression (levels) of LBP
5) Confidence 0.10 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2831899 Disease Relevance 1.59 Pain Relevance 0
An attractive hypothesis for WAY-169916-mediated activity in the spleen involves the downregulation of LBP and CD14 expression on monocytes and macrophages, resulting in a diminished immune response and ultimately resulting in the observed decreases in MMP9, IL1R2, chemokine-like factor 1, S100A8, and S100A9 through the repression of NF-?
Regulation (through) of in monocytes Gene_expression (expression) of LBP in macrophages associated with chemokine and repression
6) Confidence 0.08 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174937 Disease Relevance 0.39 Pain Relevance 0.19

General Comments

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