INT111016

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Context Info
Confidence 0.73
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 3.58
Pain Relevance 2.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (F2rl1) plasma membrane (F2rl1) signal transducer activity (F2rl1)
Anatomy Link Frequency
gut 2
blood 1
sensory neurons 1
neuron 1
colon 1
F2rl1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 15 99.96 Very High Very High Very High
Angina 1 99.00 Very High Very High Very High
spastic colon 8 98.48 Very High Very High Very High
Inflammation 59 98.20 Very High Very High Very High
qutenza 16 98.16 Very High Very High Very High
Serotonin 9 97.92 Very High Very High Very High
Central nervous system 4 97.36 Very High Very High Very High
substance P 41 96.72 Very High Very High Very High
cytokine 13 89.40 High High
hyperexcitability 1 87.52 High High
Disease Link Frequency Relevance Heat
Nociception 6 99.84 Very High Very High Very High
Diarrhoea 3 99.32 Very High Very High Very High
Cv General 3 Under Development 1 99.00 Very High Very High Very High
Pruritus 6 98.82 Very High Very High Very High
Functional Bowel Disorder 6 98.48 Very High Very High Very High
INFLAMMATION 47 98.20 Very High Very High Very High
Hypersensitivity 6 95.00 High High
Necrosis 3 94.08 High High
Cancer 11 93.72 High High
Atherosclerotic Plaque 1 84.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Protease-activated receptor-2 (PAR-2) is a G protein-coupled receptor and is expressed throughout the gut.
Gene_expression (expressed) of PAR-2 in gut
1) Confidence 0.73 Published 2003 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12801882 Disease Relevance 0 Pain Relevance 0.04
Protease-activated receptor-2 (PAR-2) is a G protein-coupled receptor and is expressed throughout the gut.
Gene_expression (expressed) of Protease-activated receptor-2 in gut
2) Confidence 0.73 Published 2003 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12801882 Disease Relevance 0 Pain Relevance 0.04
Mucosal application of faecal supernatants from IBS-D patients in mice evoked allodynia and increased CPP by 92%, both of which effects were prevented by serine protease inhibitors and dependent on PAR-2 expression.
Gene_expression (expression) of PAR-2
3) Confidence 0.67 Published 2008 Journal Gut Section Body Doc Link 18194983 Disease Relevance 0 Pain Relevance 0
Though precise mechanisms remain unclear, the action on sensory neurons expressing protease-activated receptor-2 and transient receptor potential vanilloid-1 capsaicin receptor may be involved in the inhibitory effects of tacrolimus.
Gene_expression (expressing) of protease-activated receptor-2 in sensory neurons associated with qutenza
4) Confidence 0.56 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18379077 Disease Relevance 0.33 Pain Relevance 0.39
An itch-related response, scratching, was elicited by intradermal injections of mosquito allergen (10 microg/site) in sensitized mice and SLIGRL-NH2 (protease-activated receptor-2 agonist, 50 nmol/site), histamine (100 nmol/site), serotonin (100 nmol/site) and substance P (100 nmol/site) in naive ones.
Gene_expression (injections) of protease-activated receptor-2 associated with pruritus, agonist, serotonin and substance p
5) Confidence 0.49 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18379077 Disease Relevance 0.28 Pain Relevance 0.28
Protease-activated receptor (PAR(2)) is expressed by nociceptive neurons and activated during inflammation by proteases from mast cells, the intestinal lumen, and the circulation.
Gene_expression (expressed) of Protease-activated receptor in mast cells associated with nociception and inflammation
6) Confidence 0.36 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 18325985 Disease Relevance 0.53 Pain Relevance 0.36
The protease-activated receptor-2 (PAR-2) is expressed in numerous cell types within the GI tract, suggesting both multiple functions and numerous modes of receptor activation.
Gene_expression (expressed) of PAR-2
7) Confidence 0.35 Published 2008 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 19086162 Disease Relevance 0.43 Pain Relevance 0.09
The protease-activated receptor-2 (PAR-2) is expressed in numerous cell types within the GI tract, suggesting both multiple functions and numerous modes of receptor activation.
Gene_expression (expressed) of protease-activated receptor-2
8) Confidence 0.35 Published 2008 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 19086162 Disease Relevance 0.43 Pain Relevance 0.09
We have previously demonstrated increased plasma levels of LIGHT in unstable angina patients, and here we show a similar pattern for PAR-2 expression in peripheral blood monocytes.
Gene_expression (expression) of PAR-2 in blood associated with angina
9) Confidence 0.33 Published 2009 Journal Circ. Res. Section Abstract Doc Link 19023130 Disease Relevance 1.22 Pain Relevance 0.43
Myenteric neuron protease-activated receptor 2 (PAR2) expression has been detected by reverse transcription polymerase chain reaction.
Gene_expression (expression) of PAR2 in neuron
10) Confidence 0.12 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.16 Pain Relevance 0.55
Unbalanced expression of protease-activated receptors-1 and -2 in the colon of diarrhea-predominant irritable bowel syndrome patients.
Gene_expression (expression) of protease-activated receptors-1 and -2 in colon associated with diarrhoea and spastic colon
11) Confidence 0.05 Published 2009 Journal J. Gastroenterol. Section Title Doc Link 19430717 Disease Relevance 0.20 Pain Relevance 0.10

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