INT111017

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Context Info
Confidence 0.22
First Reported 2003
Last Reported 2007
Negated 2
Speculated 1
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 2.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (F2rl1) plasma membrane (F2rl1) signal transducer activity (F2rl1)
F2rl1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 4 99.96 Very High Very High Very High
narcan 2 99.82 Very High Very High Very High
Morphine 20 99.40 Very High Very High Very High
Dopamine 8 98.44 Very High Very High Very High
addiction 1 97.68 Very High Very High Very High
tolerance 1 97.08 Very High Very High Very High
qutenza 3 95.84 Very High Very High Very High
mu opioid receptor 4 95.52 Very High Very High Very High
Nucleus accumbens 7 87.88 High High
antagonist 5 76.72 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Atropine had no effect on PAR-2 agonist-induced contractions.
Neg (no) Regulation (effect) of PAR-2 associated with agonist
1) Confidence 0.22 Published 2003 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12801882 Disease Relevance 0 Pain Relevance 0.40
Possible involvement of protease-activated receptor-1 in the regulation of morphine-induced dopamine release and hyperlocomotion by the tissue plasminogen activator-plasmin system.
Spec (Possible) Regulation (involvement) of protease-activated receptor-1 associated with dopamine, narcan and morphine
2) Confidence 0.14 Published 2007 Journal J. Neurochem. Section Title Doc Link 17286591 Disease Relevance 0 Pain Relevance 1.23
Morphine treatment had no significant effect on PAR-1 thrombin receptor-activated G protein activity, as measured by thrombin-stimulated guanosine 5'-O-(3-[35S]thio)triphosphate binding.
Neg (no) Regulation (effect) of PAR-1 thrombin receptor-activated associated with morphine
3) Confidence 0.02 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15987828 Disease Relevance 0 Pain Relevance 0.98

General Comments

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