INT11102

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Context Info
Confidence 0.42
First Reported 1992
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.50
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adra2a) plasma membrane (Adra2a) cytoplasm (Adra2a)
signal transducer activity (Adra2a)
Anatomy Link Frequency
neurons 2
Adra2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 9 99.74 Very High Very High Very High
Substantia nigra 6 98.74 Very High Very High Very High
agonist 2 93.44 High High
Disease Link Frequency Relevance Heat
Heart Rate Under Development 13 99.84 Very High Very High Very High
Bordatella Infection 1 99.20 Very High Very High Very High
Natriuresis 4 91.16 High High
Diuresis 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The treatment of SN neurons with pertussis toxin (500 ng/ ml) for 18 h completely abolished the facilitatory effect of alpha 2 adrenoceptor on Itau. 9.
Negative_regulation (abolished) of Regulation (effect) of alpha 2 adrenoceptor in neurons associated with bordatella infection and substantia nigra
1) Confidence 0.42 Published 1996 Journal J. Neurophysiol. Section Abstract Doc Link 8899617 Disease Relevance 0.10 Pain Relevance 0.12
Furthermore, the different mean arterial pressure response in the CHF and control groups at higher doses of clonidine may suggest down-regulation of the vascular alpha-2 adrenergic receptor in CHF.
Negative_regulation (down) of Regulation (regulation) of vascular alpha-2 adrenergic receptor associated with heart rate under development and clonidine
2) Confidence 0.27 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1534840 Disease Relevance 1.40 Pain Relevance 0.59

General Comments

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