INT111035

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Context Info
Confidence 0.31
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 3.31
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Kras) mitochondrion (Kras) plasma membrane (Kras)
GTPase activity (Kras)
Kras (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 12 99.68 Very High Very High Very High
diclofenac 3 95.68 Very High Very High Very High
Acupuncture 56 82.68 Quite High
aspirin 3 65.44 Quite High
cytokine 28 59.24 Quite High
Inflammation 44 54.72 Quite High
Neuropeptide 14 50.00 Quite Low
Kinase C 12 35.04 Quite Low
Central nervous system 2 24.84 Low Low
Angina 3 23.64 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 89 100.00 Very High Very High Very High
Cancer 85 100.00 Very High Very High Very High
Death 47 99.56 Very High Very High Very High
Polycystic Ovary Syndrome 62 91.68 High High
Urological Neuroanatomy 18 86.00 High High
INFLAMMATION 40 75.00 Quite High
Glioblastoma 38 74.64 Quite High
Shock 2 65.28 Quite High
Stress 8 63.20 Quite High
Brain Tumor 11 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ubiquitously expressed cyclin-dependent kinase (CDK) inhibitors, p21 and p27, were increased in all NSAID-treated cells.
Positive_regulation (increased) of Gene_expression (expressed) of p21 associated with cinod
1) Confidence 0.31 Published 2003 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 12803774 Disease Relevance 0.13 Pain Relevance 0.76
To determine whether the AR was functionally active, we analyzed hypothalamic samples for AR activation in response to expression of p21, which regulates cell-cycle progression and correlates inversely with the levels of active AR.
Spec (analyzed) Positive_regulation (response) of Gene_expression (expression) of p21
2) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722078 Disease Relevance 0.89 Pain Relevance 0.18
Cell death after exposure to different NO-donors such as SNP has been to date established through the expression of tumor suppressor gene p53 and pro-apoptotic genes such as bax, cyclin-dependent kinase inhibitor p21, the inhibited expression of anti-apoptotic protein bcl-2, the inhibited NF-?
Positive_regulation (established) of Gene_expression (expression) of p21 associated with cancer, apoptosis and death
3) Confidence 0.08 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC516785 Disease Relevance 0.67 Pain Relevance 0
Cell death after exposure to different NO-donors such as SNP has been to date established through the expression of tumor suppressor gene p53 and pro-apoptotic genes such as bax, cyclin-dependent kinase inhibitor p21, the inhibited expression of anti-apoptotic protein bcl-2, the inhibited NF-?
Positive_regulation (established) of Gene_expression (expression) of p21 associated with cancer, apoptosis and death
4) Confidence 0.08 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC516785 Disease Relevance 0.68 Pain Relevance 0
A precedent for this mechanism exists with monoterpene, an essential oil of plants (like BP) that is a natural anti-cancer compound, which causes G1 arrest and leads to an increase in p21 expression (Bardon et al. 2002).
Positive_regulation (increase) of Gene_expression (expression) of p21 associated with cancer
5) Confidence 0.05 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 0.61 Pain Relevance 0
affected cell proliferation by inducing expression of p21, and cell death by influencing various Bcl-2 family proteins and caspase-3 activation.
Positive_regulation (inducing) of Gene_expression (expression) of p21 associated with death
6) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885411 Disease Relevance 0.25 Pain Relevance 0.06
increased the levels of p21 protein in the NPCs (Fig. 3C), which was also observed using RT-PCR (Fig. 3D).
Positive_regulation (increased) of Gene_expression (levels) of p21
7) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885411 Disease Relevance 0.08 Pain Relevance 0

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