INT111036

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Context Info
Confidence 0.45
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 9.00
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cdkn1b) cell death (Cdkn1b) nucleus (Cdkn1b)
cell cycle (Cdkn1b) protein complex (Cdkn1b) response to stress (Cdkn1b)
Anatomy Link Frequency
retina 2
RG2 2
HT-29 1
inner nuclear layer 1
VSMC 1
Cdkn1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 11 99.68 Very High Very High Very High
withdrawal 14 98.20 Very High Very High Very High
agonist 6 96.96 Very High Very High Very High
diclofenac 3 95.68 Very High Very High Very High
Central nervous system 24 94.72 High High
Bile 3 85.12 High High
aspirin 3 63.04 Quite High
Kinase C 6 50.48 Quite High
COX-2 inhibitor 3 50.00 Quite Low
antagonist 3 49.04 Quite Low
Disease Link Frequency Relevance Heat
Retinoblastoma 4 99.80 Very High Very High Very High
Diabetes Mellitus 572 99.12 Very High Very High Very High
Apoptosis 125 98.56 Very High Very High Very High
Ganglion Cysts 30 98.04 Very High Very High Very High
Glioblastoma 114 97.26 Very High Very High Very High
Hypertension 186 96.72 Very High Very High Very High
Hyperglycemia 34 95.20 Very High Very High Very High
Cancer 283 94.64 High High
Diabetic Retinopathy 84 86.80 High High
Glioma 24 85.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This hypothesis was based on the fact that the Akt-mTOR-P70S6K pathway may be the upstream mechanism that increases the activity of p27Kip1 and RB with administration of PPAR-?
Positive_regulation (increases) of p27Kip1
1) Confidence 0.45 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615285 Disease Relevance 0.14 Pain Relevance 0.05
Thiazolidinediones (TZDs) are known to inhibit the proliferation of vascular smooth muscle cell (VSMC) by increasing the activity of p27Kip1 and retinoblastoma protein (RB).
Positive_regulation (increasing) of p27Kip1 in VSMC associated with retinoblastoma
2) Confidence 0.45 Published 2008 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2615285 Disease Relevance 0.18 Pain Relevance 0
The ubiquitously expressed cyclin-dependent kinase (CDK) inhibitors, p21 and p27, were increased in all NSAID-treated cells.
Positive_regulation (increased) of p27 associated with cinod
3) Confidence 0.44 Published 2003 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 12803774 Disease Relevance 0.13 Pain Relevance 0.74
There was a significant increase in p27Kip1 protein positivity in this layer in diabetic rats (1.5±1 in control WKY versus 2.5±0.5 in diabetic WKY, and 1.5±1.5 in control SHR versus 2.5±1 in diabetic SHR positive score, p=0.05; Figure 4B).
Positive_regulation (increase) of p27Kip1 associated with diabetes mellitus
4) Confidence 0.39 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 1.38 Pain Relevance 0
The accumulation of p27Kip1 in retinal tissue is accompanied by increased fibronectin expression in diabetic hypertensive rats.
Positive_regulation (accumulation) of p27Kip1 associated with diabetes mellitus and hypertension
5) Confidence 0.39 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 1.39 Pain Relevance 0
Interestingly, there was a significant increase in p27Kip1 protein in the inner nuclear layer only in diabetic SHR rats (0.7±0.6 versus 1.6±0.4 positive score for control versus diabetic SHR, p=0.02; Figure 4C).
Positive_regulation (increase) of p27Kip1 in inner nuclear layer associated with diabetes mellitus
6) Confidence 0.39 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 1.50 Pain Relevance 0
This is the first demonstration of an association between increased expression of p27Kip1 and fibronectin accumulation in retinal tissue, and could contribute to thickening of the retinal capillary basement membrane seen in diabetic retina.


Positive_regulation (accumulation) of p27Kip1 in retina associated with diabetes mellitus
7) Confidence 0.39 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 1.06 Pain Relevance 0
These authors also proposed that postmitotic Müller glia have a novel, intrinsic requirement for p27Kip1 to maintain their differentiated state.
Positive_regulation (requirement) of p27Kip1
8) Confidence 0.28 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 0.32 Pain Relevance 0.08
In the retina, p27Kip1 is expressed in a pattern coincident with the onset of the differentiation of most retinal cell types, and in vitro the accumulation of p27Kip1 in retinal cells correlates with cell cycle withdrawal and differentiation, thereby inhibiting progenitor cell proliferation [28].
Positive_regulation (accumulation) of p27Kip1 in retina associated with withdrawal
9) Confidence 0.28 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 0.40 Pain Relevance 0.12
It might be the possibility of different profile of caspase-9 and p27 activation between DBTRG and RG2 cells.
Positive_regulation (activation) of p27 in RG2
10) Confidence 0.09 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 0.50 Pain Relevance 0.04
CONCLUSION: NS-398 and nimesulide inhibit colorectal cell proliferation through induction of p21Cip1 and p27Kip1.


Positive_regulation (induction) of p27Kip1
11) Confidence 0.08 Published 2003 Journal Dig Liver Dis Section Body Doc Link 14567460 Disease Relevance 0.05 Pain Relevance 0
Instead GLA caused a significant increase in another cyclin-dependent kinase inhibitor, p27, causing a G1/S transition block and subsequently reducing S-phase.
Positive_regulation (increase) of p27
12) Confidence 0.07 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.78 Pain Relevance 0
Levels of p16, p21, Bax and AIF protein in BP-treated GBM cells were therefore measured, and protein expression levels of all four proteins increased in DBTRG-05MG and DBTRG 8401 cells; similar results for p27, Bax and AIF were detected in RG2 cells after treatment with BP (Figs 2b and c).
Positive_regulation (results) of p27 in RG2 associated with glioblastoma
13) Confidence 0.06 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 0.47 Pain Relevance 0
Thus, certain mechanisms of p53-independent activation of procaspase 9 and p27 induction may be involved in BP-induced cell apoptosis and cell growth inhibition.
Positive_regulation (induction) of p27 associated with apoptosis
14) Confidence 0.06 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 0.58 Pain Relevance 0.03
Concomitant induction of p21Cip1 mRNA indicates transcriptional modulation, whereas induction of p27Kip1 only at the protein level suggests post-translational modulation.
Positive_regulation (induction) of p27Kip1
15) Confidence 0.06 Published 2003 Journal Dig Liver Dis Section Body Doc Link 14567460 Disease Relevance 0.06 Pain Relevance 0
HT-29 cells were more sensitive to both drugs than SW-1116 cells. p21Cip1 and p27Kip1 were induced on both cell lines.
Positive_regulation (induced) of p27Kip1 in HT-29
16) Confidence 0.06 Published 2003 Journal Dig Liver Dis Section Body Doc Link 14567460 Disease Relevance 0.07 Pain Relevance 0

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