INT111037
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
The induction of diabetes in SHR leads to a reduction in renal cell replication with concomitant overexpression of p27Kip1 [14]. p27Kip1-deficient mice do not develop the classic features of diabetic nephropathy such as renal hypertrophy, glomerular expression of fibronectin, and albuminuria, all of which are marked in wild-type mice [50]. | |||||||||||||||
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These findings were associated with enhanced expression of p27Kip1 and with the classic abnormalities of diabetic retinai.e., fibronectin accumulation, increased expression of retinal vascular endothelial growth factor (VEGF), and blood-retinal barrier breakdown.
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The increase in p27Kip1 expression in diabetic WKY, was not significant (0.9±0.5 and 1.6±0.5 positive score for normal and diabetic WKY; Figure 4C). | |||||||||||||||
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The ubiquitously expressed cyclin-dependent kinase (CDK) inhibitors, p21 and p27, were increased in all NSAID-treated cells. | |||||||||||||||
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This is the first demonstration of an association between increased expression of p27Kip1 and fibronectin accumulation in retinal tissue, and could contribute to thickening of the retinal capillary basement membrane seen in diabetic retina.
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The enhanced expression of p27Kip1 and fibronectin reflected a generalized response to hyperglycemia in target organs such as the kidney. | |||||||||||||||
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This is the first demonstration of an association between increased expression of p27Kip1 and fibronectin accumulation in retinal tissue, and could contribute to thickening of the retinal capillary basement membrane seen in diabetic retina.
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Concomitant diabetes and hypertension attenuated the proliferation of retinal cells, and it is associated with an increase in p27Kip1 expression, fibronectin accumulation, and blood-retinal barrier breakdown. | |||||||||||||||
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Additionally, diabetic hypertensive rats with a reduction in the number of BrdU-positive cells and enhanced p27Kip1 expression also displayed classic characteristics of early diabetic retinal disease: enhanced fibronectin and VEGF expression and greater blood-retinal barrier breakdown. | |||||||||||||||
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However, although RG2 cells were impaired for p53 and p16, p27 and procaspase 9 expression induced by BP were increased in these cells. | |||||||||||||||
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Thus, certain mechanisms of p53-independent activation of procaspase 9 and p27 induction may be involved in BP-induced cell apoptosis and cell growth inhibition. | |||||||||||||||
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However, although RG2 cells were impaired for p53 and p16, p27 and procaspase 9 expression induced by BP were increased in these cells. | |||||||||||||||
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