INT111038

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Context Info
Confidence 0.75
First Reported 2003
Last Reported 2009
Negated 0
Speculated 3
Reported most in Body
Documents 23
Total Number 27
Disease Relevance 25.35
Pain Relevance 2.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cdkn1b) cell death (Cdkn1b) nucleus (Cdkn1b)
cell cycle (Cdkn1b) protein complex (Cdkn1b) response to stress (Cdkn1b)
Anatomy Link Frequency
retina 4
blood 3
RG2 3
podocyte 2
lymph node 1
Cdkn1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 14 99.04 Very High Very High Very High
Potency 5 94.96 High High
Central nervous system 56 94.76 High High
diclofenac 3 94.40 High High
imagery 35 92.96 High High
withdrawal 28 92.96 High High
anesthesia 17 89.44 High High
Kinase C 14 87.36 High High
Inflammation 20 79.92 Quite High
Angina 15 73.44 Quite High
Disease Link Frequency Relevance Heat
Wilms Tumor 2 99.92 Very High Very High Very High
Diabetes Mellitus 1302 99.84 Very High Very High Very High
Diabetic Retinopathy 196 99.84 Very High Very High Very High
Apoptosis 291 99.76 Very High Very High Very High
Ganglion Cysts 70 99.68 Very High Very High Very High
Ductal Carcinoma 1 99.14 Very High Very High Very High
Congenital Anomalies 98 99.12 Very High Very High Very High
Hypertension 434 98.92 Very High Very High Very High
Injury 18 98.92 Very High Very High Very High
Renal Disease 56 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, MNU induced breast tumors in rats showed distinct pre-malignant stages such as lymph node invasion, ductal carcinoma, cell proliferation, apoptosis, cyclin D1/p27 expression, codon 12 mutation frequencies in Ha-ras, microsatellite instability and apoptosis [6].
Gene_expression (expression) of p27 in lymph node associated with ductal carcinoma, malignant neoplastic disease, breast cancer, microsatellite instability and apoptosis
1) Confidence 0.75 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC1208921 Disease Relevance 1.47 Pain Relevance 0.06
The expression of proliferating cellular antigen (PCNA), cyclin-dependent kinase inhibitor p27, Wilms tumor gene (WT1), and desmin, a marker of early podocyte damage, was investigated by immunohistology.
Spec (investigated) Gene_expression (expression) of p27 in podocyte associated with wilms tumor
2) Confidence 0.52 Published 2004 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 14600034 Disease Relevance 0.35 Pain Relevance 0.09
In parallel, the increase in podocyte volume in SNX+solvent rats was abrogated by treatment with 1,25(OH)(2)D(3), and immunohistochemistry revealed less expression of desmin, PCNA, and p27, suggesting less podocyte injury and activation of the cyclin cascade.
Gene_expression (expression) of p27 in podocyte associated with injury
3) Confidence 0.52 Published 2004 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 14600034 Disease Relevance 0.45 Pain Relevance 0
The ubiquitously expressed cyclin-dependent kinase (CDK) inhibitors, p21 and p27, were increased in all NSAID-treated cells.
Gene_expression (expressed) of p27 associated with cinod
4) Confidence 0.49 Published 2003 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 12803774 Disease Relevance 0.13 Pain Relevance 0.75
In the retina, p27Kip1 is expressed in a pattern coincident with the onset of the differentiation of most retinal cell types, and in vitro the accumulation of p27Kip1 in retinal cells correlates with cell cycle withdrawal and differentiation, thereby inhibiting progenitor cell proliferation [28].
Gene_expression (expressed) of p27Kip1 in retina associated with withdrawal
5) Confidence 0.44 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 0.42 Pain Relevance 0.09
This is the first demonstration of an association between increased expression of p27Kip1 and fibronectin accumulation in retinal tissue, and could contribute to thickening of the retinal capillary basement membrane seen in diabetic retina.


Gene_expression (expression) of p27Kip1 in retina associated with diabetes mellitus
6) Confidence 0.44 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 1.06 Pain Relevance 0
The induction of diabetes in SHR leads to a reduction in renal cell replication with concomitant overexpression of p27Kip1 [14]. p27Kip1-deficient mice do not develop the classic features of diabetic nephropathy such as renal hypertrophy, glomerular expression of fibronectin, and albuminuria, all of which are marked in wild-type mice [50].
Gene_expression (overexpression) of p27Kip1 associated with hypertrophy, diabetes mellitus, renal disease and albuminuria
7) Confidence 0.44 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 1.42 Pain Relevance 0
The increase in p27Kip1 expression in diabetic WKY, was not significant (0.9±0.5 and 1.6±0.5 positive score for normal and diabetic WKY; Figure 4C).
Gene_expression (expression) of p27Kip1 associated with diabetes mellitus
8) Confidence 0.44 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 1.44 Pain Relevance 0
The effect of a reduction in p27Kip1 expression on diabetic retinopathy remains to be elucidated.
Gene_expression (expression) of p27Kip1 associated with diabetic retinopathy
9) Confidence 0.44 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 1.44 Pain Relevance 0
Detection of BrdU and p27Kip1 was performed by dewaxing slides of eye sections, rehydrating them, and placing in 2 N HCl at 31 °C for 20 min and in 0.005% trypsin in phosphate-buffered saline (PBS) at 37 °C for 2 min for antigen retrieval.
Gene_expression (Detection) of p27Kip1 in eye
10) Confidence 0.44 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 0.16 Pain Relevance 0
To investigate a potential role for cell cycle regulatory proteins in the reduction in BrdU-positive retinal cells in 12-week-old diabetic SHR, we examined the expression of p27Kip1.
Spec (examined) Gene_expression (expression) of p27Kip1 associated with diabetes mellitus
11) Confidence 0.44 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 1.40 Pain Relevance 0
These findings were associated with enhanced expression of p27Kip1 and with the classic abnormalities of diabetic retina—i.e., fibronectin accumulation, increased expression of retinal vascular endothelial growth factor (VEGF), and blood-retinal barrier breakdown.


Gene_expression (expression) of p27Kip1 in retina associated with diabetes mellitus and congenital anomalies
12) Confidence 0.44 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 0.75 Pain Relevance 0.10
The enhanced expression of p27Kip1 and fibronectin reflected a generalized response to hyperglycemia in target organs such as the kidney.
Gene_expression (expression) of p27Kip1 in kidney associated with hyperglycemia
13) Confidence 0.44 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 1.12 Pain Relevance 0
Analysis of proximal and distal colon tissue from 8- and 28-week rat/azoxymethane studies showed that GT-094 treatment reduced colon crypt proliferation by 30% to 69%, reduced inducible NO synthase (iNOS) levels by 33% to 67%, reduced poly(ADP-ribose)polymerase-1 expression and cleavage 2- to 4-fold, and elevated levels of p27 in the distal colon 3-fold.
Gene_expression (expression) of p27 in colon
14) Confidence 0.38 Published 2007 Journal Mol. Cancer Ther. Section Abstract Doc Link 17699720 Disease Relevance 1.07 Pain Relevance 0.56
Concomitant diabetes and hypertension attenuated the proliferation of retinal cells, and it is associated with an increase in p27Kip1 expression, fibronectin accumulation, and blood-retinal barrier breakdown.
Gene_expression (expression) of p27Kip1 in blood associated with diabetes mellitus and hypertension
15) Confidence 0.34 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2538494 Disease Relevance 1.05 Pain Relevance 0
There was greater expression of p27Kip1 in the ganglion cell layer of both diabetic groups (p=0.05), whereas in the inner nuclear layer there was enhanced expression only in diabetic SHR (p=0.02).
Gene_expression (expression) of p27Kip1 in inner nuclear layer associated with ganglion cysts and diabetes mellitus
16) Confidence 0.34 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2538494 Disease Relevance 1.47 Pain Relevance 0
Additionally, diabetic hypertensive rats with a reduction in the number of BrdU-positive cells and enhanced p27Kip1 expression also displayed classic characteristics of early diabetic retinal disease: enhanced fibronectin and VEGF expression and greater blood-retinal barrier breakdown.
Gene_expression (expression) of p27Kip1 in blood associated with diabetes mellitus, hypertension and retinal diseases
17) Confidence 0.34 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 1.26 Pain Relevance 0.04
This reduction was associated with enhanced p27Kip1, fibronectin, and VEGF retinal expressions and greater blood-retinal barrier breakdown.
Gene_expression (expressions) of p27Kip1 in blood
18) Confidence 0.34 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 1.13 Pain Relevance 0
The greater expression of the Cdk inhibitor, p27Kip1, probably accounts for the reduction in the number of proliferating cells in diabetic retina.
Gene_expression (expression) of p27Kip1 in retina associated with diabetes mellitus
19) Confidence 0.15 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 1.51 Pain Relevance 0.03
BP up-regulated the expression of Cyclin Kinase Inhibitor (CKI), including p21 and p27, to decrease phosphorylation of Rb proteins, and down-regulated the cell-cycle regulators, resulting in cell arrest at the G0/G1 phase for DBTRG-05MG and RG2 cells, respectively.
Gene_expression (expression) of p27 in DBTRG-05MG
20) Confidence 0.10 Published 2006 Journal Journal of Neurochemistry Section Abstract Doc Link PMC1804119 Disease Relevance 1.74 Pain Relevance 0.17

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