INT111039

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Context Info
Confidence 0.60
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 15.42
Pain Relevance 2.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Kras) mitochondrion (Kras) plasma membrane (Kras)
GTPase activity (Kras)
Anatomy Link Frequency
RG2 3
hypothalamus 1
exocrine pancreas 1
DBTRG-05MG 1
Kras (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Acupuncture 280 99.24 Very High Very High Very High
cINOD 12 98.72 Very High Very High Very High
Potency 5 94.96 High High
diclofenac 3 93.76 High High
imagery 15 92.96 High High
Chronic pancreatitis 6 86.28 High High
wide dynamic range 1 79.80 Quite High
Angina 15 73.44 Quite High
aspirin 3 65.44 Quite High
cytokine 30 58.88 Quite High
Disease Link Frequency Relevance Heat
Cancer 464 100.00 Very High Very High Very High
Apoptosis 219 100.00 Very High Very High Very High
Polycystic Ovary Syndrome 310 99.84 Very High Very High Very High
Death 60 99.56 Very High Very High Very High
Adenocarcinoma 9 99.52 Very High Very High Very High
Glioblastoma 190 98.56 Very High Very High Very High
Colon Cancer 6 98.48 Very High Very High Very High
Brain Tumor 55 97.08 Very High Very High Very High
Malignant Neoplastic Disease 36 96.60 Very High Very High Very High
Increased Venous Pressure Under Development 3 95.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For all pancreatic adenocarcinoma patients, the dominant KRAS2 mutation detected in the pancreatic juice corresponded to that found in the primary cancer.
Gene_expression (detected) of KRAS2 associated with adenocarcinoma and cancer
1) Confidence 0.60 Published 2008 Journal Cancer Biol. Ther. Section Abstract Doc Link 18075308 Disease Relevance 1.06 Pain Relevance 0.35
Second, they show that, while Kras activation in immature acinar and centroacinar cells is readily able to induce ductal neoplasia, Kras-mediated tumorigenesis in mature exocrine pancreas requires the induction of chronic epithelial injury.
Gene_expression (activation) of Kras in exocrine pancreas associated with cancer and injury
2) Confidence 0.48 Published 2007 Journal Cancer Cell Section Abstract Doc Link 17349578 Disease Relevance 0.62 Pain Relevance 0.08
The ubiquitously expressed cyclin-dependent kinase (CDK) inhibitors, p21 and p27, were increased in all NSAID-treated cells.
Gene_expression (expressed) of p21 associated with cinod
3) Confidence 0.35 Published 2003 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 12803774 Disease Relevance 0.13 Pain Relevance 0.75
To determine whether the AR was functionally active, we analyzed hypothalamic samples for AR activation in response to expression of p21, which regulates cell-cycle progression and correlates inversely with the levels of active AR.
Gene_expression (expression) of p21
4) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722078 Disease Relevance 0.88 Pain Relevance 0.18
Functional androgen response elements are present in the promoter sequences of p21 [17], and the regulation of p21 expression is AR dependent [18].
Gene_expression (expression) of p21
5) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722078 Disease Relevance 0.89 Pain Relevance 0.21
However, low-frequency EA did not elicit additional effects on p21 or c-FOS expression in PCOS rat hypothalamus.


Gene_expression (expression) of p21 in hypothalamus associated with polycystic ovary syndrome and acupuncture
6) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722078 Disease Relevance 1.15 Pain Relevance 0.23
In both PCOS groups, p21 levels were lower than in controls by western blot analysis (Fig. 2).
Gene_expression (levels) of p21 associated with polycystic ovary syndrome
7) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722078 Disease Relevance 0.94 Pain Relevance 0.17
Expression of AR, p21, and c-FOS was detected by western blot analysis with a standard procedure [49].
Gene_expression (Expression) of p21
8) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722078 Disease Relevance 0.16 Pain Relevance 0.04
Cell death after exposure to different NO-donors such as SNP has been to date established through the expression of tumor suppressor gene p53 and pro-apoptotic genes such as bax, cyclin-dependent kinase inhibitor p21, the inhibited expression of anti-apoptotic protein bcl-2, the inhibited NF-?
Gene_expression (expression) of p21 associated with cancer, apoptosis and death
9) Confidence 0.13 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC516785 Disease Relevance 0.67 Pain Relevance 0
Cell death after exposure to different NO-donors such as SNP has been to date established through the expression of tumor suppressor gene p53 and pro-apoptotic genes such as bax, cyclin-dependent kinase inhibitor p21, the inhibited expression of anti-apoptotic protein bcl-2, the inhibited NF-?
Gene_expression (expression) of p21 associated with cancer, apoptosis and death
10) Confidence 0.13 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC516785 Disease Relevance 0.67 Pain Relevance 0
Thus, utilisation of anti-EGFR is only authorized in non mutated KRAS tumors and for the first time in metastatic CRC, we have the possibility to enrich the population in selecting non mutated KRAS population and to treat only patients having increased chance of response and of secondary resections of initially non resectable metastases.
Gene_expression (population) of KRAS associated with cancer, colon cancer and metastasis
11) Confidence 0.10 Published 2009 Journal Gastroenterol. Clin. Biol. Section Abstract Doc Link 19717258 Disease Relevance 0.45 Pain Relevance 0
BP up-regulated the expression of Cyclin Kinase Inhibitor (CKI), including p21 and p27, to decrease phosphorylation of Rb proteins, and down-regulated the cell-cycle regulators, resulting in cell arrest at the G0/G1 phase for DBTRG-05MG and RG2 cells, respectively.
Gene_expression (expression) of p21 in DBTRG-05MG
12) Confidence 0.08 Published 2006 Journal Journal of Neurochemistry Section Abstract Doc Link PMC1804119 Disease Relevance 1.74 Pain Relevance 0.17
Levels of p16, p21, Bax and AIF protein in BP-treated GBM cells were therefore measured, and protein expression levels of all four proteins increased in DBTRG-05MG and DBTRG 8401 cells; similar results for p27, Bax and AIF were detected in RG2 cells after treatment with BP (Figs 2b and c).
Gene_expression (Levels) of p21 in RG2 associated with glioblastoma
13) Confidence 0.06 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 0.50 Pain Relevance 0
The protein expression of cdk2, cdk4, cdk6, cyclin D1 and cyclin E in BP-treated GBM cells was also measured, and all five proteins were decreased in DBTRG-05MG and DBTRG 8401 cells; similar results for cdk2, cdk4, cdk6, cyclin D1, cyclin E and p21 were detected in RG2 cells after treatment with BP (Fig. 2b).
Gene_expression (detected) of p21 in RG2 associated with glioblastoma
14) Confidence 0.06 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 0.32 Pain Relevance 0
A precedent for this mechanism exists with monoterpene, an essential oil of plants (like BP) that is a natural anti-cancer compound, which causes G1 arrest and leads to an increase in p21 expression (Bardon et al. 2002).
Gene_expression (expression) of p21 associated with cancer
15) Confidence 0.06 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 0.61 Pain Relevance 0
Overexpressed LKB1 increases expression of several p21 (CDK inhibitor), p53 responsive genes.8-11) This tumor suppressor protein may have an important role in atherosclerosis, especially in restenosis.
Gene_expression (expression) of p21 associated with cardiovascular disease, cancer and increased venous pressure under development
16) Confidence 0.06 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC3008825 Disease Relevance 1.74 Pain Relevance 0
increased the levels of p21 protein in the NPCs (Fig. 3C), which was also observed using RT-PCR (Fig. 3D).
Gene_expression (levels) of p21
17) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885411 Disease Relevance 0.08 Pain Relevance 0
affected cell proliferation by inducing expression of p21, and cell death by influencing various Bcl-2 family proteins and caspase-3 activation.
Gene_expression (expression) of p21 associated with death
18) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885411 Disease Relevance 0.25 Pain Relevance 0.06
The increase in p53 seen in the GLA treated tumour did not lead to altered p21 expression which could explain why pRb was not increased in this model.
Gene_expression (expression) of p21 associated with cancer
19) Confidence 0.05 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.85 Pain Relevance 0
BP up-regulated the expression of Cyclin Kinase Inhibitor (CKI), including p21 and p27, to decrease phosphorylation of Rb proteins, and down-regulated the cell-cycle regulators, resulting in cell arrest at the G0/G1 phase for DBTRG-05MG and RG2 cells, respectively.
Gene_expression (expression) of p21 in RG2
20) Confidence 0.03 Published 2006 Journal Journal of Neurochemistry Section Abstract Doc Link PMC1804119 Disease Relevance 1.74 Pain Relevance 0.17

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