INT111047

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Context Info
Confidence 0.34
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.56
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Aqp2) plasma membrane (Aqp2) protein complex (Aqp2)
transmembrane transport (Aqp2) lysosome (Aqp2) cytoplasm (Aqp2)
Anatomy Link Frequency
pia mater 2
Kidney 2
Aqp2 (Mus musculus)
Pain Link Frequency Relevance Heat
bradykinin 2 75.00 Quite High
Neuropeptide 39 54.52 Quite High
Central nervous system 39 42.96 Quite Low
anesthesia 1 25.00 Low Low
Substantia nigra 4 22.88 Low Low
medulla 2 20.40 Low Low
ischemia 1 6.00 Low Low
Multiple sclerosis 29 5.00 Very Low Very Low Very Low
Inflammation 17 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diuresis 1 97.60 Very High Very High Very High
Natriuresis 1 97.08 Very High Very High Very High
Neuromyelitis Optica 2 96.04 Very High Very High Very High
Congenital Anomalies 15 96.00 Very High Very High Very High
Cancer 2 83.96 Quite High
Pathologic Dilatation 3 83.24 Quite High
Motor Neuron Diseases 15 82.08 Quite High
Dementia 18 80.92 Quite High
Chronic Fatigue Syndrome 11 80.64 Quite High
Increased Venous Pressure Under Development 4 78.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
example, have reduced renal expression of AQP2 and AQP4 [46].
Negative_regulation (reduced) of Gene_expression (expression) of AQP2
1) Confidence 0.34 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2643053 Disease Relevance 0.76 Pain Relevance 0.03
The astroglial water channel aquaporin (AQP4) is essential for the maintenance of BBB integrity.52 Antibodies to AQP4 have a highly specific role in neuromyelitis optica (NMO) and characteristically bind to cerebral microvessels, pia mater and VRSs.53 Secretin is important for other aquaporin expression via vasopressin, secretin receptor-null mice for example have reduced renal expression of AQP2 and AQP4.54 Thus VIP impairment may influence water channel function.
Negative_regulation (reduced) of Gene_expression (expression) of AQP2 in pia mater associated with neuromyelitis optica
2) Confidence 0.27 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 1.07 Pain Relevance 0
Kidney aquaporin-2 expression was decreased by 50%, whereas renin, ANG type 1 receptor, and Na+-K+-ATPase levels were not different in B2R(-/-)CRD mice compared with controls.
Negative_regulation (decreased) of Gene_expression (expression) of aquaporin-2 in Kidney associated with congenital anomalies
3) Confidence 0.18 Published 2003 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 12805091 Disease Relevance 1.73 Pain Relevance 0.07

General Comments

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