INT111050

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Context Info
Confidence 0.58
First Reported 2003
Last Reported 2010
Negated 6
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 5.97
Pain Relevance 17.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Nav1) cytoskeleton (Nav1) cytoplasm (Nav1)
Anatomy Link Frequency
neurons 16
brain 4
mossy fibers 4
retinal ganglion cells 4
margin 2
Nav1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nav1.2 188 100.00 Very High Very High Very High
Nav1.6 83 100.00 Very High Very High Very High
Nav1.7 52 100.00 Very High Very High Very High
Nav1.1 23 100.00 Very High Very High Very High
nav1.3 12 100.00 Very High Very High Very High
nav1.8 11 100.00 Very High Very High Very High
Pain 51 99.28 Very High Very High Very High
tetrodotoxin 53 99.20 Very High Very High Very High
qutenza 3 98.12 Very High Very High Very High
Hyperalgesia 4 97.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 361 99.48 Very High Very High Very High
Pain 53 99.28 Very High Very High Very High
Multiple Sclerosis 14 99.20 Very High Very High Very High
Ganglion Cysts 21 98.68 Very High Very High Very High
Hyperalgesia 4 97.84 Very High Very High Very High
INFLAMMATION 10 97.08 Very High Very High Very High
Inflammatory Pain 2 94.08 High High
Herpes Simplex Virus 1 87.24 High High
Nociception 11 82.44 Quite High
Disease 57 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The med phenotype in mice is due to a mutation in the SCN8A gene resulting in loss of Nav1.6 expression.
Negative_regulation (loss) of Gene_expression (expression) of Nav1 associated with nav1.6
1) Confidence 0.58 Published 2006 Journal Glia Section Abstract Doc Link 16078241 Disease Relevance 0.07 Pain Relevance 0.74
On the other hand, the finding that inactivation times were consistently and by a big margin larger in mdx5cv cells enables to explain the increased stimulated inward Na+ current in spite of the decreased Nav1.4 expression levels.
Negative_regulation (decreased) of Gene_expression (expression) of Nav1 in margin
2) Confidence 0.57 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0 Pain Relevance 0
We and others (Ribaux et al., 2001) obtained similar results with EDL muscle where Nav1.4 expression was decreased by 40% in mdx5cv compared with control muscle (unpublished data).
Negative_regulation (decreased) of Gene_expression (expression) of Nav1 in muscle
3) Confidence 0.57 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0 Pain Relevance 0.18
The initiation, development, and expression of kindling in wild-type mice were compared to Nav1.6 +/-med(tg) mice, which have reduced expression of Nav1.6.
Negative_regulation (reduced) of Gene_expression (expression) of Nav1
4) Confidence 0.43 Published 2009 Journal Epilepsia Section Body Doc Link 18637833 Disease Relevance 0 Pain Relevance 0
Our findings of a loss of Nav1.6 and increased expression of Nav1.2 suggest that electrogenesis in EAE may revert to a stage similar to that observed in immature retinal ganglion cells in which Nav1.2 channels support conduction of action potentials along axons.
Negative_regulation (loss) of Gene_expression (expression) of Nav1 in retinal ganglion cells associated with ganglion cysts, action potential, multiple sclerosis, nav1.2 and nav1.6
5) Confidence 0.42 Published 2003 Journal Brain Section Abstract Doc Link 12805113 Disease Relevance 1.22 Pain Relevance 1.67
Our findings of a loss of Nav1.6 and increased expression of Nav1.2 suggest that electrogenesis in EAE may revert to a stage similar to that observed in immature retinal ganglion cells in which Nav1.2 channels support conduction of action potentials along axons.
Negative_regulation (loss) of Gene_expression (expression) of Nav1 in retinal ganglion cells associated with ganglion cysts, action potential, multiple sclerosis, nav1.2 and nav1.6
6) Confidence 0.42 Published 2003 Journal Brain Section Abstract Doc Link 12805113 Disease Relevance 1.22 Pain Relevance 1.67
RT-PCR analysis detected Nav1.1, Nav1.2 and Nav1.6, but not Nav1.3, Nav1.4, Nav 1.5 or Nav1.8 Na+ channel alpha subunit gene expression in cultured Purkinje neurons, as observed in vivo.
Neg (not) Negative_regulation (detected) of Gene_expression (expression) of Nav1 in neurons associated with nav1.3, nav1.1, nav1.2, nav1.8 and nav1.6
7) Confidence 0.42 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17448145 Disease Relevance 0.07 Pain Relevance 0.60
RT-PCR analysis detected Nav1.1, Nav1.2 and Nav1.6, but not Nav1.3, Nav1.4, Nav 1.5 or Nav1.8 Na+ channel alpha subunit gene expression in cultured Purkinje neurons, as observed in vivo.
Neg (not) Negative_regulation (detected) of Gene_expression (expression) of Nav1 in neurons associated with nav1.3, nav1.1, nav1.2, nav1.8 and nav1.6
8) Confidence 0.42 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17448145 Disease Relevance 0.07 Pain Relevance 0.60
RT-PCR analysis detected Nav1.1, Nav1.2 and Nav1.6, but not Nav1.3, Nav1.4, Nav 1.5 or Nav1.8 Na+ channel alpha subunit gene expression in cultured Purkinje neurons, as observed in vivo.
Neg (not) Negative_regulation (detected) of Gene_expression (expression) of Nav1 in neurons associated with nav1.3, nav1.1, nav1.2, nav1.8 and nav1.6
9) Confidence 0.42 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17448145 Disease Relevance 0.07 Pain Relevance 0.60
RT-PCR analysis detected Nav1.1, Nav1.2 and Nav1.6, but not Nav1.3, Nav1.4, Nav 1.5 or Nav1.8 Na+ channel alpha subunit gene expression in cultured Purkinje neurons, as observed in vivo.
Neg (not) Negative_regulation (detected) of Gene_expression (expression) of Nav1 in neurons associated with nav1.3, nav1.1, nav1.2, nav1.8 and nav1.6
10) Confidence 0.42 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17448145 Disease Relevance 0.07 Pain Relevance 0.60
RT-PCR analysis detected Nav1.1, Nav1.2 and Nav1.6, but not Nav1.3, Nav1.4, Nav 1.5 or Nav1.8 Na+ channel alpha subunit gene expression in cultured Purkinje neurons, as observed in vivo.
Neg (not) Negative_regulation (detected) of Gene_expression (expression) of Nav1 in neurons associated with nav1.3, nav1.1, nav1.2, nav1.8 and nav1.6
11) Confidence 0.42 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17448145 Disease Relevance 0.07 Pain Relevance 0.60
RT-PCR analysis detected Nav1.1, Nav1.2 and Nav1.6, but not Nav1.3, Nav1.4, Nav 1.5 or Nav1.8 Na+ channel alpha subunit gene expression in cultured Purkinje neurons, as observed in vivo.
Neg (not) Negative_regulation (detected) of Gene_expression (expression) of Nav1 in neurons associated with nav1.3, nav1.1, nav1.2, nav1.8 and nav1.6
12) Confidence 0.42 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17448145 Disease Relevance 0.07 Pain Relevance 0.60
This data suggests that both the missense and in-frame deletion pore mutations hamper the surface expression of Nav1.7, and may explain the reason for the loss of pain phenotype seen in these patients.


Negative_regulation (hamper) of Gene_expression (expression) of Nav1.7 in pore associated with pain and nav1.7
13) Confidence 0.41 Published 2010 Journal Human Mutation Section Body Doc Link PMC2966863 Disease Relevance 0.10 Pain Relevance 0.88
In addition, they report reduced total Nav1.2 protein levels and increased cell surface expression and mossy fiber localization of Nav1.2 in BACE1-/- brains, consistent with the findings of Kim et al. for Nav1.1 [35].
Negative_regulation (reduced) of Gene_expression (expression) of Nav1 in mossy fiber associated with nav1.1 and nav1.2
14) Confidence 0.40 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2933677 Disease Relevance 0.50 Pain Relevance 0.72
Application of the vector, but not a control vector encoding only GFP, prevented an increase in Nav1.7 expression in GFP-positive neurons and prevented development of hyperalgesia in both C and Adelta thermonociceptive tests.
Negative_regulation (prevented) of Gene_expression (expression) of Nav1 in neurons associated with hyperalgesia, adelta and nav1.7
15) Confidence 0.40 Published 2005 Journal Hum. Gene Ther. Section Abstract Doc Link 15761266 Disease Relevance 0.75 Pain Relevance 1.09
A Western blot of whole brain homogenates shows similar levels of Nav1.2 as well as Nav1.6, the other prominent axonal CNS ?
Negative_regulation (shows) of Gene_expression (levels) of Nav1 in brain associated with nav1.2 and nav1.6
16) Confidence 0.39 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2933677 Disease Relevance 0.19 Pain Relevance 0.75
A Western blot of whole brain homogenates shows similar levels of Nav1.2 as well as Nav1.6, the other prominent axonal CNS ?
Negative_regulation (shows) of Gene_expression (levels) of Nav1 in brain associated with nav1.2 and nav1.6
17) Confidence 0.39 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2933677 Disease Relevance 0.19 Pain Relevance 0.75
Nav1.2 levels in mossy fibers do not correlate with seizure phenotype
Negative_regulation (mossy fibers) of Gene_expression (levels) of Nav1 in mossy fibers associated with convulsion and nav1.2
18) Confidence 0.39 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2933677 Disease Relevance 0.32 Pain Relevance 0.62
The corresponding values in mV for the inactivation of Nav1.2/Nav1.6 channels are V1/2(?
Negative_regulation (inactivation) of Gene_expression (channels) of Nav1 associated with nav1.2 and nav1.6
19) Confidence 0.36 Published 2010 Journal Neuroscience Section Body Doc Link PMC2954315 Disease Relevance 0 Pain Relevance 0.64
The corresponding values in mV for the inactivation of Nav1.2/Nav1.6 channels are V1/2(?
Negative_regulation (inactivation) of Gene_expression (channels) of Nav1 associated with nav1.2 and nav1.6
20) Confidence 0.36 Published 2010 Journal Neuroscience Section Body Doc Link PMC2954315 Disease Relevance 0 Pain Relevance 0.64

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