INT111051

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Context Info
Confidence 0.59
First Reported 2003
Last Reported 2010
Negated 6
Speculated 0
Reported most in Abstract
Documents 64
Total Number 66
Disease Relevance 25.51
Pain Relevance 47.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Nav1) cytoskeleton (Nav1) cytoplasm (Nav1)
Anatomy Link Frequency
neurons 14
sciatic nerve 7
nerve 5
optic nerve 3
neuronal 2
Nav1 (Mus musculus)
Pain Link Frequency Relevance Heat
sodium channel 761 100.00 Very High Very High Very High
Pain 300 100.00 Very High Very High Very High
tetrodotoxin 296 100.00 Very High Very High Very High
Nav1.7 222 100.00 Very High Very High Very High
nav1.8 162 100.00 Very High Very High Very High
Nav1.2 91 100.00 Very High Very High Very High
Nav1.6 84 100.00 Very High Very High Very High
Nav1.9 52 100.00 Very High Very High Very High
nav1.3 27 100.00 Very High Very High Very High
Nav1.1 23 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 192 99.72 Very High Very High Very High
Death 51 99.52 Very High Very High Very High
Neuropathic Pain 146 99.46 Very High Very High Very High
Pain 348 99.36 Very High Very High Very High
Multiple Sclerosis 245 99.20 Very High Very High Very High
Ganglion Cysts 261 99.04 Very High Very High Very High
Demyelinating Disease 112 98.90 Very High Very High Very High
Targeted Disruption 155 98.84 Very High Very High Very High
Rare Diseases 1 98.24 Very High Very High Very High
Somatoform Disorder 30 96.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, we observed activity-dependent down-regulation of Nav1.8 and Nav1.9 mRNA and protein levels after stimulation, as demonstrated by quantitative polymerase chain reaction and immunocytochemistry.
Negative_regulation (regulation) of Nav1 associated with nav1.8 and nav1.9
1) Confidence 0.59 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 14515348 Disease Relevance 0.20 Pain Relevance 1.29
These changes within the optic nerve are paralleled by decreased levels of Nav1.6 and increased Nav1.2 protein, together with increased levels of Nav1.2 mRNA, within retinal ganglion cells in EAE.
Negative_regulation (decreased) of Nav1 in optic nerve associated with ganglion cysts, multiple sclerosis, nav1.2 and nav1.6
2) Confidence 0.58 Published 2003 Journal Brain Section Abstract Doc Link 12805113 Disease Relevance 1.17 Pain Relevance 1.78
On the other hand, the finding that inactivation times were consistently and by a big margin larger in mdx5cv cells enables to explain the increased stimulated inward Na+ current in spite of the decreased Nav1.4 expression levels.
Negative_regulation (decreased) of Nav1 in margin
3) Confidence 0.57 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0 Pain Relevance 0
We then tested whether the basal Na+ influx measured in control and dystrophic muscles was affected by TTX, a high-affinity inhibitor of Nav1.4 channels (Ritchie and Rogart, 1977).
Negative_regulation (inhibitor) of Nav1 in muscles associated with tetrodotoxin
4) Confidence 0.57 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0 Pain Relevance 0.28
Consistent with these results, we have demonstrated a reduction in Nav1.8 and Nav1.9 immunostaining on peripherin-positive unmyelinated axons in sciatic nerves from CNTN-/- mice but detected no changes in the expression for the two major TTX-S channels Nav1.6 and Nav1.7.
Negative_regulation (reduction) of Nav1 in sciatic nerves associated with sciatic nerve, nav1.8, nav1.7, nav1.6, unmyelinated and nav1.9
5) Confidence 0.57 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16029194 Disease Relevance 0.40 Pain Relevance 1.53
Consistent with these results, we have demonstrated a reduction in Nav1.8 and Nav1.9 immunostaining on peripherin-positive unmyelinated axons in sciatic nerves from CNTN-/- mice but detected no changes in the expression for the two major TTX-S channels Nav1.6 and Nav1.7.
Negative_regulation (reduction) of Nav1 in sciatic nerves associated with sciatic nerve, nav1.8, nav1.7, nav1.6, unmyelinated and nav1.9
6) Confidence 0.57 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16029194 Disease Relevance 0.40 Pain Relevance 1.53
Block of Nav1.8 by small molecules.
Negative_regulation (Block) of Nav1.8 associated with analgesic and nav1.8
7) Confidence 0.56 Published 2007 Journal Channels (Austin) Section Title Doc Link 18690030 Disease Relevance 0.17 Pain Relevance 0.93
Using whole-cell patch-clamp recording, we observed a greater than two-fold reduction of tetrodotoxin-resistant (TTX-R) Nav1.8 and Nav1.9 current densities in IB4+ DRG neurons cultured from CNTN-/- vs.
Negative_regulation (reduction) of Nav1 in neurons associated with dorsal root ganglion, tetrodotoxin, nav1.8 and nav1.9
8) Confidence 0.49 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16029194 Disease Relevance 0.45 Pain Relevance 1.48
Neuropathic pain develops normally in mice lacking both Nav1.7 and Nav1.8

Two voltage gated sodium channel ?

Negative_regulation (lacking) of Nav1 associated with sodium channel, neuropathic pain, nav1.8 and nav1.7
9) Confidence 0.43 Published 2005 Journal Mol Pain Section Title Doc Link PMC1215513 Disease Relevance 0.73 Pain Relevance 1.68
In contrast, we observed activity-dependent down-regulation of Nav1.8 and Nav1.9 mRNA and protein levels after stimulation, as demonstrated by quantitative polymerase chain reaction and immunocytochemistry.
Negative_regulation (regulation) of Nav1 associated with nav1.8 and nav1.9
10) Confidence 0.43 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 14515348 Disease Relevance 0.20 Pain Relevance 1.30
By contrast, nociceptor-associated mRNA transcripts (e.g., Nav1.8, P2xr3, and Runx-1) were downregulated, resulting in lower levels of protein and functional expression. qRT-PCR analysis also showed lowered levels of expression of nociceptor-specific pre-mRNA transcripts.
Negative_regulation (downregulated) of Nav1 in nociceptor associated with nociceptor and nav1.8
11) Confidence 0.43 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20702715 Disease Relevance 0.53 Pain Relevance 1.43
We also show that blocking the interaction of CaM and Nav1.8 using CBP or the IQ/DE substitution causes a buildup of inactivated channels and, in the case of the IQ/DE mutation, stimulation even at a low frequency of 0.1 Hz significantly enhances the frequency-dependent inhibition of the Nav1.8 current.
Negative_regulation (inhibition) of Nav1 associated with nav1.8
12) Confidence 0.43 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16598065 Disease Relevance 0.33 Pain Relevance 1.20
However, with increasing age, in the mutant mouse we observed a decrease in the total number of nodal Nav1.6 clusters, a decrease in the density of Nav1.6 channels at nodes, and an increase in the average size of the Nav1.6 clusters.
Negative_regulation (decrease) of Nav1 in nodes associated with nav1.6
13) Confidence 0.43 Published 2003 Journal Glia Section Abstract Doc Link 14515333 Disease Relevance 0 Pain Relevance 1.05
Thus, transverse bands are not required for Nav1.6 clustering and localization at nodes or for exclusion of Nav1.2 from myelinated nerve fibers, but are required for the maintenance of nodal Nav1.6 cluster size and density.
Negative_regulation (exclusion) of Nav1 in nerve associated with nav1.2 and nav1.6
14) Confidence 0.43 Published 2003 Journal Glia Section Abstract Doc Link 14515333 Disease Relevance 0 Pain Relevance 1.02
Our findings of a loss of Nav1.6 and increased expression of Nav1.2 suggest that electrogenesis in EAE may revert to a stage similar to that observed in immature retinal ganglion cells in which Nav1.2 channels support conduction of action potentials along axons.
Negative_regulation (loss) of Nav1 in retinal ganglion cells associated with ganglion cysts, action potential, multiple sclerosis, nav1.2 and nav1.6
15) Confidence 0.42 Published 2003 Journal Brain Section Abstract Doc Link 12805113 Disease Relevance 1.22 Pain Relevance 1.66
These changes within the optic nerve are paralleled by decreased levels of Nav1.6 and increased Nav1.2 protein, together with increased levels of Nav1.2 mRNA, within retinal ganglion cells in EAE.
Negative_regulation (levels) of Nav1 in optic nerve associated with ganglion cysts, multiple sclerosis, nav1.2 and nav1.6
16) Confidence 0.42 Published 2003 Journal Brain Section Abstract Doc Link 12805113 Disease Relevance 1.17 Pain Relevance 1.73
These changes within the optic nerve are paralleled by decreased levels of Nav1.6 and increased Nav1.2 protein, together with increased levels of Nav1.2 mRNA, within retinal ganglion cells in EAE.
Negative_regulation (levels) of Nav1 in optic nerve associated with ganglion cysts, multiple sclerosis, nav1.2 and nav1.6
17) Confidence 0.42 Published 2003 Journal Brain Section Abstract Doc Link 12805113 Disease Relevance 1.18 Pain Relevance 1.75
The occurrence of ongoing spontaneous neuronal activity was significantly less in mice lacking Nav 1.8 compared to control.
Negative_regulation (lacking) of Nav in neuronal
18) Confidence 0.42 Published 2006 Journal Mol Pain Section Abstract Doc Link PMC1403745 Disease Relevance 0.35 Pain Relevance 0.48
However, no difference was observed between mice expressing or lacking Nav 1.8 in neuronal responses to warm and noxious heat and electrical stimulation therefore stimulus-evoked neuronal excitability is not globally affected by this genetic modification.
Negative_regulation (lacking) of Nav in neuronal associated with neuronal excitability
19) Confidence 0.42 Published 2006 Journal Mol Pain Section Body Doc Link PMC1403745 Disease Relevance 0.11 Pain Relevance 0.33
This study clearly shows that mice lacking the VGSC Nav 1.8 have marked deficits in the evoked activity of spinal dorsal horn neurones in response to mechanical stimuli, whether it be brush, von Frey or pinch.
Negative_regulation (lacking) of Nav in spinal associated with spinal dorsal horn
20) Confidence 0.42 Published 2006 Journal Mol Pain Section Body Doc Link PMC1403745 Disease Relevance 0.08 Pain Relevance 0.22

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