INT111052

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Context Info
Confidence 0.70
First Reported 2003
Last Reported 2010
Negated 1
Speculated 4
Reported most in Body
Documents 44
Total Number 51
Disease Relevance 18.98
Pain Relevance 35.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Nav1) cytoskeleton (Nav1) cytoplasm (Nav1)
Anatomy Link Frequency
neurons 12
nerve 10
sensory neurons 5
plasma 4
spike 4
Nav1 (Mus musculus)
Pain Link Frequency Relevance Heat
sodium channel 429 100.00 Very High Very High Very High
nav1.8 349 100.00 Very High Very High Very High
Nav1.7 172 100.00 Very High Very High Very High
nav1.3 150 100.00 Very High Very High Very High
Nav1.2 127 100.00 Very High Very High Very High
Nav1.6 66 100.00 Very High Very High Very High
Nav1.9 65 100.00 Very High Very High Very High
Neuropeptide 11 100.00 Very High Very High Very High
Inflammation 181 99.98 Very High Very High Very High
Eae 26 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 58 100.00 Very High Very High Very High
INFLAMMATION 185 99.98 Very High Very High Very High
Inflammatory Pain 34 99.92 Very High Very High Very High
Rhinitis 6 99.76 Very High Very High Very High
Ganglion Cysts 240 99.68 Very High Very High Very High
Convulsion 272 99.52 Very High Very High Very High
Nociception 108 99.44 Very High Very High Very High
Experimental Autoimmune Encephalomyelitis 4 98.96 Very High Very High Very High
Multiple Sclerosis 49 98.88 Very High Very High Very High
Congenital Anomalies 33 98.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we demonstrate a robust increase of sodium channel Nav1.6 expression in activated microglia and macrophages in EAE and MS.
Positive_regulation (increase) of Gene_expression (expression) of Nav1 in macrophages associated with multiple sclerosis, sodium channel and nav1.6
1) Confidence 0.70 Published 2005 Journal Glia Section Abstract Doc Link 15390090 Disease Relevance 1.28 Pain Relevance 1.03
Expression of Nav1.7 has been reported to increase in sensory neurons subsequent to induction of inflammation [24].
Positive_regulation (increase) of Gene_expression (Expression) of Nav1 in sensory neurons associated with inflammation and nav1.7
2) Confidence 0.70 Published 2005 Journal Mol Pain Section Body Doc Link PMC1215513 Disease Relevance 1.21 Pain Relevance 1.92
Our findings of a loss of Nav1.6 and increased expression of Nav1.2 suggest that electrogenesis in EAE may revert to a stage similar to that observed in immature retinal ganglion cells in which Nav1.2 channels support conduction of action potentials along axons.
Positive_regulation (increased) of Gene_expression (expression) of Nav1 in retinal ganglion cells associated with ganglion cysts, action potential, multiple sclerosis, nav1.2 and nav1.6
3) Confidence 0.69 Published 2003 Journal Brain Section Abstract Doc Link 12805113 Disease Relevance 1.21 Pain Relevance 1.66
Thus, Nav1.4 channels are underexpressed, rather than overexpressed, in mdx fibers, highlighting the importance of a proper explanation of the increased Na+ entry.


Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Nav1
4) Confidence 0.68 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0 Pain Relevance 0.17
One possible explanation for the increase in Na+ influx is that it is caused by overexpression of Nav1.4 in mdx muscles.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Nav1 in muscles
5) Confidence 0.68 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0.49 Pain Relevance 0.30
In addition, they report reduced total Nav1.2 protein levels and increased cell surface expression and mossy fiber localization of Nav1.2 in BACE1-/- brains, consistent with the findings of Kim et al. for Nav1.1 [35].
Positive_regulation (increased) of Gene_expression (expression) of Nav1 in mossy fiber associated with nav1.1 and nav1.2
6) Confidence 0.64 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2933677 Disease Relevance 0.49 Pain Relevance 0.72
Application of the vector, but not a control vector encoding only GFP, prevented an increase in Nav1.7 expression in GFP-positive neurons and prevented development of hyperalgesia in both C and Adelta thermonociceptive tests.
Positive_regulation (increase) of Gene_expression (expression) of Nav1 in neurons associated with hyperalgesia, adelta and nav1.7
7) Confidence 0.64 Published 2005 Journal Hum. Gene Ther. Section Abstract Doc Link 15761266 Disease Relevance 0.75 Pain Relevance 1.08
These results provide clear evidence of the involvement of an increased expression of the Nav1.7 channel in nociceptive neurons in the development of inflammatory hyperalgesia.
Positive_regulation (increased) of Gene_expression (expression) of Nav1 in neurons associated with nociception, hyperalgesia, inflammation and nav1.7
8) Confidence 0.64 Published 2005 Journal Hum. Gene Ther. Section Abstract Doc Link 15761266 Disease Relevance 0.99 Pain Relevance 1.08
Increased nerve fiber expression of sensory sodium channels Nav1.7, Nav1.8, And Nav1.9 in rhinitis.
Positive_regulation (Increased) of Gene_expression (expression) of Nav1 in nerve associated with rhinitis, neuropeptide, sodium channel, nav1.8, nav1.7 and nav1.9
9) Confidence 0.64 Published 2008 Journal Laryngoscope Section Title Doc Link 18197135 Disease Relevance 0.10 Pain Relevance 0.79
The injury-induced expression of Nav1.3 in large (A-fiber) DRG neurons [24] is thought to be one of the mechanisms underlying the hypersensitivity.
Positive_regulation (induced) of Gene_expression (expression) of Nav1 in neurons associated with dorsal root ganglion, nav1.3, hypersensitivity and injury
10) Confidence 0.52 Published 2008 Journal Mol Pain Section Body Doc Link PMC2365930 Disease Relevance 1.00 Pain Relevance 1.24
This value was not statistically different from the V1/2 value for the cells from Nav1.8(-/-) animals transfected with GFP alone.
Positive_regulation (transfected) of Gene_expression (transfected) of Nav1 associated with nav1.8
11) Confidence 0.50 Published 2007 Journal Mol Pain Section Body Doc Link PMC1892009 Disease Relevance 0.22 Pain Relevance 1.05
Irrespective of the modulatory process involved, our additional results with transfection of Nav1.8 into cells from Nav1.8(-/-) animals demonstrates that the process is not permanent and is dependent on the absence of Nav1.8 channels.
Positive_regulation (transfection) of Gene_expression (transfection) of Nav1 associated with nav1.8
12) Confidence 0.50 Published 2007 Journal Mol Pain Section Body Doc Link PMC1892009 Disease Relevance 0.38 Pain Relevance 1.60
The pRK-Nav1.8 plasmid used for transfections of Nav1.8 into DRG from Nav1.8(-/-) mice was a gift from John Wood (University College, London).
Positive_regulation (transfections) of Gene_expression (transfections) of Nav1 associated with dorsal root ganglion and nav1.8
13) Confidence 0.50 Published 2007 Journal Mol Pain Section Body Doc Link PMC1892009 Disease Relevance 0.45 Pain Relevance 1.03
The pRK-Nav1.8 plasmid used for transfections of Nav1.8 into DRG from Nav1.8(-/-) mice was a gift from John Wood (University College, London).
Positive_regulation (transfections) of Gene_expression (transfections) of Nav1 associated with dorsal root ganglion and nav1.8
14) Confidence 0.50 Published 2007 Journal Mol Pain Section Body Doc Link PMC1892009 Disease Relevance 0.45 Pain Relevance 0.97
CONCLUSION: Primary erythermalgia may be a neuropathic disorder of the small peripheral sensory and sympathetic neurons, and may be caused by hyperexcitability of Nav1.7.


Positive_regulation (hyperexcitability) of Gene_expression (hyperexcitability) of Nav1 in neurons
15) Confidence 0.50 Published 2005 Journal Arch. Neurol. Section Body Doc Link 16216943 Disease Relevance 0.06 Pain Relevance 0
Our findings of a loss of Nav1.6 and increased expression of Nav1.2 suggest that electrogenesis in EAE may revert to a stage similar to that observed in immature retinal ganglion cells in which Nav1.2 channels support conduction of action potentials along axons.
Positive_regulation (increased) of Gene_expression (expression) of Nav1 in retinal ganglion cells associated with ganglion cysts, action potential, multiple sclerosis, nav1.2 and nav1.6
16) Confidence 0.50 Published 2003 Journal Brain Section Abstract Doc Link 12805113 Disease Relevance 1.22 Pain Relevance 1.66
Work is in progress to assess the role and the distribution of Nav1.5, as well as the interaction of ?
Positive_regulation (assess) of Gene_expression (distribution) of Nav1
17) Confidence 0.49 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0 Pain Relevance 0
On the other hand, the finding that inactivation times were consistently and by a big margin larger in mdx5cv cells enables to explain the increased stimulated inward Na+ current in spite of the decreased Nav1.4 expression levels.
Positive_regulation (increased) of Gene_expression (expression) of Nav1 in margin
18) Confidence 0.49 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0 Pain Relevance 0
Moreover, it has been shown that in the heart, DGC is required for the proper expression and function of the Nav1.5 isoform (Gavillet et al., 2006).
Positive_regulation (required) of Gene_expression (expression) of Nav1 in heart
19) Confidence 0.49 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0 Pain Relevance 0.06
To investigate whether the increased sodium entry observed in mdx5cv cells is caused by overexpression of Nav1.4 channels, we performed Western blot and real time PCR analyses.
Spec (whether) Positive_regulation (overexpression) of Gene_expression (overexpression) of Nav1
20) Confidence 0.49 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0 Pain Relevance 0.24

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