INT111053

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Context Info
Confidence 0.46
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.97
Pain Relevance 3.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Nav1) cytoskeleton (Nav1) cytoplasm (Nav1)
Anatomy Link Frequency
optic nerve 2
Nav1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nav1.2 9 100.00 Very High Very High Very High
Nav1.6 7 99.10 Very High Very High Very High
unmyelinated 10 98.60 Very High Very High Very High
tetrodotoxin 21 96.64 Very High Very High Very High
burning pain 1 95.24 Very High Very High Very High
Pain 62 92.08 High High
c fibre 5 91.68 High High
Nav1.7 47 89.52 High High
Sciatic nerve 8 89.20 High High
Action potential 14 83.24 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 16 99.04 Very High Very High Very High
Erythermalgia 12 98.98 Very High Very High Very High
Multiple Sclerosis 7 98.32 Very High Very High Very High
Somatoform Disorder 10 98.00 Very High Very High Very High
Pain 73 95.24 Very High Very High Very High
Targeted Disruption 12 93.64 High High
Nerve Compression Syndromes 2 81.28 Quite High
Neuropathic Pain 6 79.84 Quite High
INFLAMMATION 7 75.00 Quite High
Demyelinating Disease 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These changes within the optic nerve are paralleled by decreased levels of Nav1.6 and increased Nav1.2 protein, together with increased levels of Nav1.2 mRNA, within retinal ganglion cells in EAE.
Positive_regulation (increased) of Positive_regulation (levels) of Nav1 in optic nerve associated with ganglion cysts, multiple sclerosis, nav1.2 and nav1.6
1) Confidence 0.46 Published 2003 Journal Brain Section Abstract Doc Link 12805113 Disease Relevance 1.15 Pain Relevance 1.69
The missense mutations causing PE are gain of function mutations that predominantly enhance the activation of Nav 1.7 [Cummins et al., 2004].
Positive_regulation (enhance) of Positive_regulation (activation) of Nav 1.7 associated with erythermalgia
2) Confidence 0.39 Published 2010 Journal Human Mutation Section Body Doc Link PMC2966863 Disease Relevance 1.44 Pain Relevance 0.73
In these animals the NaV1.8 activation curve was shifted to a more depolarised potential (i.e. a greater depolarisation is needed for activation) but no changes were apparent for NaV1.9.
Positive_regulation (shifted) of Positive_regulation (activation) of NaV1
3) Confidence 0.27 Published 2010 Journal Neuroscience Letters Section Body Doc Link PMC2977848 Disease Relevance 0.16 Pain Relevance 0.47
It has been proposed that specific and enhanced transport of NaV1.8 mRNA into the axons may account for this up-regulation and that local mRNA accumulation could contribute to increased axonal NaV1.8 protein levels.
Positive_regulation (contribute) of Positive_regulation (increased) of NaV1
4) Confidence 0.25 Published 2010 Journal Neuroscience Letters Section Body Doc Link PMC2977848 Disease Relevance 0.22 Pain Relevance 0.52
Figure 3 summarizes the intensity changes of the spontaneous augmentation of NaV1.9, which were induced by compounds added to the pipette solution.
Positive_regulation (augmentation) of Positive_regulation (augmentation) of NaV1
5) Confidence 0.19 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2857352 Disease Relevance 0 Pain Relevance 0.11

General Comments

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