INT111055

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Context Info
Confidence 0.71
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 9
Disease Relevance 2.04
Pain Relevance 4.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc1a2)
Anatomy Link Frequency
sciatic nerve 2
neuronal 1
nerve 1
astrocyte 1
synapses 1
Slc1a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 302 100.00 Very High Very High Very High
withdrawal 18 99.76 Very High Very High Very High
spinal dorsal horn 73 99.44 Very High Very High Very High
Hippocampus 7 99.44 Very High Very High Very High
Morphine 7 99.32 Very High Very High Very High
Sciatic nerve 54 98.84 Very High Very High Very High
opiate 3 95.04 Very High Very High Very High
Dorsal horn 21 93.88 High High
Spinal cord 54 93.40 High High
Peripheral nerve injury 6 89.64 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 79 97.68 Very High Very High Very High
Cv Unclassified Under Development 51 89.44 High High
Neuropathic Pain 14 88.24 High High
Hypersensitivity 25 81.44 Quite High
Toxicity 4 80.08 Quite High
Nociception 19 79.84 Quite High
Disease 8 56.00 Quite High
Injury 22 53.52 Quite High
Death 10 39.92 Quite Low
Pain 12 35.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This conclusion is consistent with reports on the distribution of GLT-1 and GLAST in hippocampus and cerebellum where the transporters were found to be in astrocytes [18-21].
Localization (distribution) of GLT-1 in cerebellum associated with hippocampus
1) Confidence 0.71 Published 2009 Journal Mol Pain Section Body Doc Link PMC2676254 Disease Relevance 0.15 Pain Relevance 0.28
This issue was explored in this study by examination of changes in the expression and cellular localization of GLT-1 and GLAST in the spinal dorsal horn over time following partial sciatic nerve ligation (PNSL).


Localization (localization) of GLT-1 in sciatic nerve associated with spinal dorsal horn and sciatic nerve
2) Confidence 0.67 Published 2009 Journal Mol Pain Section Body Doc Link PMC2676254 Disease Relevance 0.49 Pain Relevance 0.60
GLT-1 and GLAST were not co-localized with the microglia marker OX-42 or the neuron marker NeuN at baseline, but rather only in cells positive for the astrocyte marker GFAP.
Localization (localized) of GLT-1 in astrocyte
3) Confidence 0.67 Published 2009 Journal Mol Pain Section Body Doc Link PMC2676254 Disease Relevance 0.12 Pain Relevance 0.26
The results of this study demonstrate plasticity not only in the expression levels but also in the cellular localization of the glutamate transporters GLT-1 and GLAST following partial sciatic nerve ligation.
Localization (localization) of GLT-1 in sciatic nerve associated with glutamate and sciatic nerve
4) Confidence 0.67 Published 2009 Journal Mol Pain Section Body Doc Link PMC2676254 Disease Relevance 0.16 Pain Relevance 0.25
As noted above, there was no co-localization of GLT-1 or GLAST with OX-42 positive microglia in the absence of nerve injury.
Localization (localization) of GLT-1 in nerve associated with nervous system injury
5) Confidence 0.67 Published 2009 Journal Mol Pain Section Body Doc Link PMC2676254 Disease Relevance 0.30 Pain Relevance 0.07
GLAST, and GLT-1 are predominantly localized in astrocytes [2,20,21], while EAAC-1, EAAT4, and EAAT5 appears to be mostly neuronal [22-25].
Localization (localized) of GLT-1 in neuronal
6) Confidence 0.63 Published 2007 Journal Mol Pain Section Body Doc Link PMC1864984 Disease Relevance 0.60 Pain Relevance 1.02
The translocation of GLT1 at synapses during morphine withdrawal provides a neuronal mechanism for modulation of excitatory neurotransmission during opiate abuse.
Localization (translocation) of GLT1 in synapses associated with opiate, withdrawal and morphine
7) Confidence 0.61 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12805317 Disease Relevance 0 Pain Relevance 1.14
acid transporters: EAAT1 (GLAST), EAAT2 (GLT-1), EAAT3 (EAAC1),
Localization (transporters) of EAAT2
8) Confidence 0.57 Published 2007 Journal Experimental Diabetes Research Section Body Doc Link PMC1940058 Disease Relevance 0.06 Pain Relevance 0.53
This conclusion is consistent with reports on the distribution of GLT-1 and GLAST in hippocampus and cerebellum where the transporters were found to be in astrocytes [18-21].
Localization (distribution) of GLT-1 in hippocampus associated with hippocampus
9) Confidence 0.24 Published 2009 Journal Mol Pain Section Body Doc Link PMC2676254 Disease Relevance 0.15 Pain Relevance 0.28

General Comments

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