INT111056

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Context Info
Confidence 0.13
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.15
Pain Relevance 7.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Flvcr2) transmembrane transport (Flvcr2)
Anatomy Link Frequency
frontal cortex 3
neuronal 2
neurons 2
brain 2
thalamus 2
Flvcr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 148 100.00 Very High Very High Very High
Dopamine 134 100.00 Very High Very High Very High
gABA 42 100.00 Very High Very High Very High
Locus ceruleus 12 99.68 Very High Very High Very High
Nucleus accumbens 8 99.32 Very High Very High Very High
Hippocampus 19 99.04 Very High Very High Very High
addiction 8 98.68 Very High Very High Very High
Substantia nigra 5 98.32 Very High Very High Very High
Morphine 20 98.24 Very High Very High Very High
Thalamus 1 98.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Schizophrenia 222 99.88 Very High Very High Very High
Depression 63 99.76 Very High Very High Very High
Morphine Dependence 6 98.68 Very High Very High Very High
Urological Neuroanatomy 6 98.40 Very High Very High Very High
Diabetes Mellitus 47 97.36 Very High Very High Very High
Targeted Disruption 1 96.08 Very High Very High Very High
Respiratory Tract Infection 1 95.36 Very High Very High Very High
Hyperalgesia 82 94.84 High High
INFLAMMATION 69 87.36 High High
Nervous System Injury 7 84.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By Northern blot analysis, the expression of glial glutamate transporter GLT-1, but not GLAST, mRNA was decreased in the striatum/nucleus accumbens (NAc) and thalamus of morphine-dependent rats.
Negative_regulation (decreased) of Gene_expression (expression) of transporter in thalamus associated with nucleus accumbens, glutamate, thalamus and morphine
1) Confidence 0.13 Published 2004 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15542740 Disease Relevance 0.34 Pain Relevance 1.49
Immunoblot analysis showed that expression of GLT1 (glutamate transporter subtype 1) was identified to be upregulated in synaptosomes but not in total tissues, suggesting a redistribution of glutamate transporter expression.
Negative_regulation (redistribution) of Gene_expression (expression) of transporter associated with glutamate
2) Confidence 0.06 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12805317 Disease Relevance 0 Pain Relevance 1.17
Dopamine transporter autoradiography
Negative_regulation (Dopamine) of Gene_expression (autoradiography) of transporter associated with dopamine
3) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0.16 Pain Relevance 0.28
Since astroglial glutamate transporters play an important role in maintaining an appropriate level of glutamate extracellular concentration, a reduction in GLT-1 glutamate transporter expression may lead to a build up of glutamate concentration in the synaptic cleft, resulting in neuronal hyperexcitability and behavioral hyperalgesia.
Negative_regulation (reduction) of Gene_expression (expression) of transporter in neuronal associated with hyperalgesia, glutamate and hyperexcitability
4) Confidence 0.04 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 0.84 Pain Relevance 0.99
The expression of norepinephrine transporter mRNA has been shown to be decreased in the locus coeruleus and other brain regions in experimentally diabetic rats,19 suggesting a possible role for this neurotransmitter in the development of diabetes, especially in the case of comorbid depression where this monoamine is thought to be reduced.
Negative_regulation (decreased) of Gene_expression (expression) of transporter mRNA in brain associated with neurotransmitter, depression, diabetes mellitus, locus ceruleus and monoamine
5) Confidence 0.03 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2819761 Disease Relevance 1.22 Pain Relevance 0.80
Ueda et al (2003) showed that zonisamide could also increase extracellular GABA by the up-regulation of a neuronal glutamate transporter (ie, EAAC-1) and a decreased production of the GABA transporter (ie, GAT-1) in the rat hippocampus and frontal cortex.
Negative_regulation (decreased) of Gene_expression (production) of transporter in frontal cortex associated with glutamate, gaba, urological neuroanatomy and hippocampus
6) Confidence 0.03 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671817 Disease Relevance 0.34 Pain Relevance 0.88
M), a nontransported inhibitor selective for the glial GLT-1 transporter (IC50 = 23 ?
Negative_regulation (inhibitor) of Gene_expression (glial) of transporter
7) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2713213 Disease Relevance 0 Pain Relevance 0.24
There is a well-known association of enhanced DA D2 function in schizophrenia, and the D1A receptor function may also be abnormal in schizophrenia.165 The level of expression of DA transporter is possibly an illness trait in schizophrenia,166 and mouse models of schizophrenia have reduced expression of DA transporter.167 Increased transcription of TH in the substantia nigra is also found in schizophrenia,168 and transgenic mice used as animal models of schizophrenia have reduced density and numbers of TH neurons in the substantia nigra pars compacta.169
Negative_regulation (reduced) of Gene_expression (expression) of transporter in neurons associated with targeted disruption, dopamine, substantia nigra and schizophrenia
8) Confidence 0.02 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.91 Pain Relevance 0.45
Ueda et al (2003) showed that zonisamide could also increase extracellular GABA by the up-regulation of a neuronal glutamate transporter (ie, EAAC-1) and a decreased production of the GABA transporter (ie, GAT-1) in the rat hippocampus and frontal cortex.
Negative_regulation (decreased) of in hippocampus Gene_expression (production) of transporter in frontal cortex associated with glutamate, gaba, urological neuroanatomy and hippocampus
9) Confidence 0.01 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671817 Disease Relevance 0.34 Pain Relevance 0.88

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