INT11106

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Context Info
Confidence 0.67
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 10.29
Pain Relevance 4.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Lbp) transport (Lbp) extracellular space (Lbp)
extracellular region (Lbp)
Anatomy Link Frequency
liver 5
lungs 1
trunk 1
Lbp (Mus musculus)
Pain Link Frequency Relevance Heat
backache 59 100.00 Very High Very High Very High
Inflammation 37 98.60 Very High Very High Very High
Pain 5 71.16 Quite High
chemokine 5 17.56 Low Low
cytokine 11 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Low Back Pain 61 100.00 Very High Very High Very High
Spondylolysis 4 99.88 Very High Very High Very High
Intervertebral Disk Degeneration 8 99.52 Very High Very High Very High
Necrosis 16 99.18 Very High Very High Very High
Cancer 11 99.00 Very High Very High Very High
Injury 35 98.92 Very High Very High Very High
INFLAMMATION 23 98.60 Very High Very High Very High
Pneumonia 23 95.44 Very High Very High Very High
Joint Instability 1 89.44 High High
Stress 3 75.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among the athletes, the duration of training during the past 12 months (min.wk-1) was higher in subjects with the experience of LBP during the past 12 months (N = 23) compared with nonsymptomatic subjects (N = 76) (mean 493 +/- 308 min.wk-1 vs 354 +/- 160 min.wk-1; P less than 0.0001).
Gene_expression (experience) of LBP associated with backache
1) Confidence 0.67 Published 1992 Journal Med Sci Sports Exerc Section Abstract Doc Link 1534863 Disease Relevance 0.79 Pain Relevance 0.70
Tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, lipopolysaccharide binding protein (LBP) and CD14 mRNA (messenger ribonucleic acid) expression in mouse liver were determined by semiquantitative reverse transcription polymerase chain reaction (RT-PCR) analysis. 3.
Gene_expression (expression) of lipopolysaccharide binding protein in liver associated with necrosis and cancer
2) Confidence 0.65 Published 2006 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 16620297 Disease Relevance 1.11 Pain Relevance 0.14
However, not all cases of disc degeneration (DD) or spondylolysis were symptomatic of LBP.
Gene_expression (symptomatic) of LBP associated with intervertebral disk degeneration, spondylolysis and backache
3) Confidence 0.58 Published 1997 Journal Disabil Rehabil Section Abstract Doc Link 9442988 Disease Relevance 2.26 Pain Relevance 1.53
Tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, lipopolysaccharide binding protein (LBP) and CD14 mRNA (messenger ribonucleic acid) expression in mouse liver were determined by semiquantitative reverse transcription polymerase chain reaction (RT-PCR) analysis. 3.
Gene_expression (xpression ) of LBP in liver associated with necrosis and cancer
4) Confidence 0.53 Published 2006 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 16620297 Disease Relevance 1.10 Pain Relevance 0.14
Disc degeneration and spondylolytic symptoms were also noted as sources of LBP.
Gene_expression (sources) of LBP associated with intervertebral disk degeneration and backache
5) Confidence 0.52 Published 1997 Journal Disabil Rehabil Section Abstract Doc Link 9442988 Disease Relevance 2.17 Pain Relevance 1.47
TNF-alpha, IL-6, LBP and CD14 mRNA expression in mouse liver may be involved in BCG plus LPS induced liver injury.
Gene_expression (expression) of LBP in liver associated with injury
6) Confidence 0.46 Published 2006 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 16620297 Disease Relevance 0.77 Pain Relevance 0.04
Simulations showed that longer delays found in LBP, in general, did not produce unstable balancing, but did result in increased trunk displacement (p<0.001) and trunk moment (p=0.001).
Neg (not) Gene_expression (produce) of LBP in trunk associated with backache
7) Confidence 0.45 Published 2009 Journal J Biomech Section Abstract Doc Link 19121523 Disease Relevance 0.24 Pain Relevance 0.24
LBP levels in the lungs of WT and CD14KO mice treated with high dose LPS, however, did not differ (data not shown).
Gene_expression (levels) of LBP in lungs
8) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.27 Pain Relevance 0.14
The protective mechanism of paeoniflorin might be partially related to modulation of TNF-alpha, IL-6, LBP and CD14 mRNA expressions in mouse liver.
Gene_expression (expressions) of LBP in liver
9) Confidence 0.20 Published 2006 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 16620297 Disease Relevance 0.62 Pain Relevance 0.04
The increase in TNF-alpha, LBP and CD14 mRNA expression in mouse liver after BCG and LPS injection was significantly decreased by paeoniflorin (100 mg/kg) and was changed by paeoniflorin (25, 50 mg/kg) at different time-point.
Gene_expression (expression) of LBP in liver
10) Confidence 0.20 Published 2006 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 16620297 Disease Relevance 0.96 Pain Relevance 0.08

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