INT111066

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Context Info
Confidence 0.61
First Reported 2003
Last Reported 2011
Negated 6
Speculated 13
Reported most in Body
Documents 40
Total Number 53
Disease Relevance 31.47
Pain Relevance 4.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bace1) peptidase activity (Bace1) Golgi apparatus (Bace1)
endoplasmic reticulum (Bace1) enzyme binding (Bace1)
Anatomy Link Frequency
brain 6
tail 2
plaque 2
cleavage 1
hippocampus 1
Bace1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 673 99.90 Very High Very High Very High
cytokine 220 99.78 Very High Very High Very High
sodium channel 117 99.60 Very High Very High Very High
Abeta 2 99.00 Very High Very High Very High
Hippocampus 267 98.92 Very High Very High Very High
ischemia 184 98.88 Very High Very High Very High
antagonist 65 98.36 Very High Very High Very High
cINOD 306 97.64 Very High Very High Very High
glial activation 50 95.92 Very High Very High Very High
cerebral cortex 50 94.56 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 833 99.90 Very High Very High Very High
Disease 4297 99.70 Very High Very High Very High
Amyloid Plaque 431 99.62 Very High Very High Very High
Immunization 9 99.60 Very High Very High Very High
Brain Injury 247 99.56 Very High Very High Very High
Stress 1068 99.54 Very High Very High Very High
Targeted Disruption 1353 99.36 Very High Very High Very High
Urological Neuroanatomy 84 99.24 Very High Very High Very High
Hypoxia 499 99.18 Very High Very High Very High
Cv Unclassified Under Development 151 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, in addition to a number of transcriptional factors acting as either activators or repressors of BACE1 transcription, alternative splicing events, intracellular signal transduction pathways, post-translational modifications and alterations in protein half-life can affect the level and enzymatic activity of BACE1.
Regulation (affect) of BACE1
1) Confidence 0.61 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.32 Pain Relevance 0
Features of BACE1 5’ untranslated region (5’UTR) such as the GC content, the length, evolutionary conservation and the presence of upstream AUGs indicate that this 5’UTR may play an important role in the regulation of translational control and several studies indicate that BACE1 may be regulated in this fashion [203-205].
Spec (may) Regulation (regulated) of BACE1
2) Confidence 0.61 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.20 Pain Relevance 0
The intracellular trafficking and localization of the BACE1 protein is largely controlled by targeting signals present in the cytosolic portion of the C-terminal tail [235].
Regulation (controlled) of BACE1 protein in tail
3) Confidence 0.61 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.06 Pain Relevance 0
While these studies imply that splicing events are involved in the regulation of BACE1 enzymatic activity, the possible functions and brain distributions of BACE1 splice variants in AD brain remain to be established.
Regulation (regulation) of BACE1 in brain associated with disease
4) Confidence 0.61 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.31 Pain Relevance 0
BACE1 activity is also affected by the microenvironment, being stimulated by various lipid moieties [219], and the stability of BACE1 may be affected by ischemic conditions [185].
Spec (may) Regulation (affected) of BACE1
5) Confidence 0.61 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 1.52 Pain Relevance 0.04
Furthermore, BACE1 interacts with a number of other protein moieties, many of which are involved in protein trafficking, and so alterations in the level of these proteins may in turn affect BACE1 levels, subcellular localization and/or activity.
Spec (may) Regulation (affect) of BACE1
6) Confidence 0.61 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.21 Pain Relevance 0
As McConlogue and colleagues discuss, the co-expression of APPswe with the PS1 transgene in the Laird study led to an aggressive model of plaque development that may somehow impact the sensitivity of APP metabolism to alterations in BACE1 levels.
Regulation (alterations) of BACE1 in plaque
7) Confidence 0.61 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.26 Pain Relevance 0
While the reasons for these opposing data remain unknown, the reversal of the effect by a M1 antagonist was not investigated in the latter study, with the possibility that the observed effect on BACE1 levels may be due to mechanisms other than M1 receptor activation.
Spec (observed) Regulation (effect) of BACE1 associated with antagonist
8) Confidence 0.61 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.46 Pain Relevance 0.10
To gain insight into the regulation of BACE1 and identify other potential therapeutic targets in the ?
Regulation (regulation) of BACE1
9) Confidence 0.61 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.50 Pain Relevance 0
Indeed, features of BACE1 5' untranslated region (5'UTR) such as the GC content, the length, evolutionary conservation and the presence of upstream AUGs indicate that this 5'UTR may play an important role in the regulation of translational control and several studies indicate that BACE1 may be regulated in this fashion [102-104].
Spec (may) Regulation (regulated) of BACE1
10) Confidence 0.61 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.60 Pain Relevance 0.20
Our results indicate that PGE2 signaling via the EP2 receptor promotes age-dependent oxidative damage and increased Abeta peptide burden in this model of AD, possibly via effects on BACE1 activity.
Regulation (effects) of BACE1 in PGE2 associated with disease and abeta
11) Confidence 0.59 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16267225 Disease Relevance 1.20 Pain Relevance 0.12
Similar to changes in BACE1 levels, the stress treatment significantly elevated levels of hippocampal full-length APP in female 5XFAD mice [F(1,14) = 32.47, p < 0.0001] (Figure 3F) but not in male 5XFAD mice (Figure 3E).
Regulation (changes) of BACE1 associated with stress
12) Confidence 0.54 Published 2010 Journal Mol Brain Section Body Doc Link PMC2988063 Disease Relevance 0.48 Pain Relevance 0.14
The cell biology of BACE1 was investigated in order to further understand BACE1 regulation and to identify other potential therapeutic targets in the ?
Spec (investigated) Regulation (regulation) of BACE1
13) Confidence 0.53 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.64 Pain Relevance 0.09
The intracellular trafficking and localization of the BACE1 protein is largely controlled by targeting signals present in the cytosolic portion of the C-terminal tail [127].
Regulation (controlled) of BACE1 protein in tail
14) Confidence 0.45 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.07 Pain Relevance 0
Furthermore, proinflammatory cytokines appear to modulate BACE1 expression [91,92] and following A?
Spec (appear) Regulation (modulate) of BACE1 associated with cytokine
15) Confidence 0.45 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.38 Pain Relevance 0.05
As McConlogue and colleagues discuss, the co-expression of APPswe with the PS1 transgene in the Laird study led to an aggressive model of plaque development that may somehow impact the sensitivity of APP metabolism to alterations in BACE1 levels.
Regulation (alterations) of BACE1 in plaque
16) Confidence 0.45 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.36 Pain Relevance 0
It should also be noted that levels of the full-length APP were not altered in BACE1+/?
Neg (not) Regulation (altered) of BACE1
17) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 0.37 Pain Relevance 0.07
Sodium channel protein levels are unaltered in BACE1-/- mice
Regulation (unaltered) of BACE1 associated with sodium channel
18) Confidence 0.39 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2933677 Disease Relevance 0.15 Pain Relevance 0.39
In contrast to changes observed in the hippocampus, the adverse behavioral stress did not significantly affect cortical BACE1 or full-length APP levels in male or female 5XFAD mice (data not shown).
Neg (not) Regulation (affect) of BACE1 in hippocampus associated with stress and hippocampus
19) Confidence 0.39 Published 2010 Journal Mol Brain Section Body Doc Link PMC2988063 Disease Relevance 0.41 Pain Relevance 0.21
Potentially, the identification of proteins specifically binding to long, GC-rich 5'UTR may yield new insights into the possible regulation of BACE1 translation.
Spec (possible) Regulation (regulation) of BACE1
20) Confidence 0.39 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2442055 Disease Relevance 0.47 Pain Relevance 0.08

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