INT111067

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Context Info
Confidence 0.68
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 32
Total Number 33
Disease Relevance 21.20
Pain Relevance 4.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Psen1) Golgi apparatus (Psen1) endoplasmic reticulum (Psen1)
intracellular (Psen1) embryo development (Psen1) protein complex (Psen1)
Anatomy Link Frequency
brain 6
astrocytes 4
microglia 4
neuronal 2
Notch 2
Psen1 (Mus musculus)
Psen1 - L235P (1)
Pain Link Frequency Relevance Heat
bDMF 20 100.00 Very High Very High Very High
Eae 39 99.96 Very High Very High Very High
cINOD 310 99.52 Very High Very High Very High
glial activation 17 99.04 Very High Very High Very High
Inflammatory mediators 15 97.88 Very High Very High Very High
Glutamate 6 96.36 Very High Very High Very High
Inflammation 366 94.28 High High
Hippocampus 149 93.00 High High
interneuron 6 91.12 High High
sodium channel 10 90.44 High High
Disease Link Frequency Relevance Heat
Disease 1652 100.00 Very High Very High Very High
Targeted Disruption 688 100.00 Very High Very High Very High
Alzheimer's Dementia 636 100.00 Very High Very High Very High
Brain Injury 89 99.82 Very High Very High Very High
Hypoxia 50 99.16 Very High Very High Very High
INFLAMMATION 505 97.48 Very High Very High Very High
Gliosis 23 96.80 Very High Very High Very High
Parkinson's Disease 30 94.36 High High
Myocardial Infarction 6 93.96 High High
Dilated Cardiomyopathy 1 93.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transgenic overexpression of human PS1 in mice replaces endogenous mouse PS1 by a highly selective and compensatory mechanism, and the extent of replacement is proportional to the level of exogenous PS1, which suggests that exogenous and endogenous PS compete for limiting cellular factors [16,20].
Positive_regulation (overexpression) of Gene_expression (overexpression) of PS1 associated with targeted disruption
1) Confidence 0.68 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.18 Pain Relevance 0
However, PS1 expression is upregulated in reactive astrocytes and activated microglia under pathological conditions such as those occurring in AD, brain injury and hypoxia (Weggen et al., 1998; Peers et al., 2004; Nadler et al., 2008).


Positive_regulation (upregulated) of Gene_expression (expression) of PS1 in microglia associated with hypoxia, disease and brain injury
2) Confidence 0.68 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 0.29 Pain Relevance 0.22
Overexpression of the PS1-M146L mutation enhances the cellular drug response to A beta 42 lowering NSAIDs as compared with cells expressing wild-type PS1.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of PS1 associated with cinod
3) Confidence 0.67 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12805356 Disease Relevance 0.37 Pain Relevance 0.85
As described above, overexpression of PS1 alone neither substantially increases the levels of mature PS1 derivatives nor elevates A?
Positive_regulation (overexpression) of Gene_expression (overexpression) of PS1
4) Confidence 0.49 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.26 Pain Relevance 0.03
Similarly, the absence of PS1 or the expression of FAD-linked PS1 mutant results in increased glycogen synthase kinase-3?
Positive_regulation (absence) of Gene_expression (expression) of PS1 associated with disease
5) Confidence 0.49 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.70 Pain Relevance 0
In several cases PS1/?
Positive_regulation (cases) of Gene_expression (/) of PS1
6) Confidence 0.49 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.30 Pain Relevance 0.05
An independent C. elegans genetic screen identified aph-1 and pen-2 as enhancers of sel-12/Presenilin function, and showed that aph-2, aph-1 and pen-2 are required for Notch signaling, PS1 accumulation, and ?
Positive_regulation (enhancers) of Gene_expression (function) of Presenilin in Notch
7) Confidence 0.49 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.07 Pain Relevance 0
Similarly, the absence of PS1 or the expression of FAD-linked PS1 mutant results in increased glycogen synthase kinase-3?
Positive_regulation (results) of Gene_expression (expression) of PS1 associated with disease
8) Confidence 0.49 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.70 Pain Relevance 0
However, PS1 expression is upregulated in reactive astrocytes and activated microglia under pathological conditions such as those occurring in AD, brain injury and hypoxia (Weggen et al., 1998; Peers et al., 2004; Nadler et al., 2008).


Positive_regulation (upregulated) of Gene_expression (expression) of PS1 in microglia associated with hypoxia, disease and brain injury
9) Confidence 0.49 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 0.29 Pain Relevance 0.22
peptides by increasing expression of APP and PS1, which in turn affects glial activation and neuronal function (Bates et al., 2002).
Positive_regulation (increasing) of Gene_expression (expression) of PS1 in neuronal associated with glial activation
10) Confidence 0.45 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 1.27 Pain Relevance 0.30
Similarly, PS1 expression increases in astrocytes under hypoxia conditions contributing to enhancement of intracellular calcium, whereas inhibition of PS1 reverses the effects of hypoxia on calcium signaling (Peers et al., 2004).
Positive_regulation (increases) of Gene_expression (expression) of PS1 in astrocytes associated with hypoxia
11) Confidence 0.45 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 1.56 Pain Relevance 0.19
Consistent with a role of PS on tau phosphorylation, overexpression of mutant PS1 in mice results in activation of GSK-3?
Positive_regulation (overexpression) of Gene_expression (overexpression) of mutant PS1 associated with eae
12) Confidence 0.43 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 1.22 Pain Relevance 0.17
Increased expression of mutant PS1 in astrocytes has been shown to contribute to astrocyte reactivity in response to ATP and glutamate through a mechanism involving increased Ca2+ oscillations (Johnston et al., 2006).
Positive_regulation (Increased) of Gene_expression (expression) of mutant PS1 in astrocytes associated with glutamate
13) Confidence 0.40 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 1.29 Pain Relevance 0.27
Double transgenic mice overexpressing FAD-linked amyloid precursor protein with Swedish mutation and PS-1 with deletion of exon 9 (APPswe/PS1dE9) demonstrated early A?
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of PS-1 associated with targeted disruption and alzheimer's dementia
14) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696039 Disease Relevance 2.35 Pain Relevance 0
These data show directly that changes in PS1 conformation can be detected following various manipulations of PS1 itself, Pen2, Aph1, APP, and pharmacological agents known as ?
Positive_regulation (manipulations) of Gene_expression (itself) of PS1
15) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0.15 Pain Relevance 0
GFP-PS1 NT to RFP-PS1 loop FRET efficiency (GFP lifetime shortening) was monitored by FLIM in cells transfected with G-PS1-R only (presumed mixture of intra- and inter-molecular FRET), co-transfected with G-PS1-R and untagged wild type PS1 in 1?
Positive_regulation (transfected) of Gene_expression (transfected) of G-PS1
16) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0 Pain Relevance 0.03
GFP-PS1 NT to RFP-PS1 loop FRET efficiency (GFP lifetime shortening) was monitored by FLIM in cells transfected with G-PS1-R only (presumed mixture of intra- and inter-molecular FRET), co-transfected with G-PS1-R and untagged wild type PS1 in 1?
Positive_regulation (transfected) of Gene_expression (transfected) of G-PS1
17) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0 Pain Relevance 0.03
Noticeably, the endogenous PS1 was reduced in cells transfected with G-PS1-R, suggesting that other components of the ?
Positive_regulation (transfected) of Gene_expression (transfected) of G-PS1
18) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0 Pain Relevance 0
Except for the PS1 model, these murine models of AD typically express sufficiently high levels of hAPP and A?
Neg (Except) Positive_regulation (Except) of Gene_expression (model) of PS1 associated with disease
19) Confidence 0.35 Published 2008 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2755760 Disease Relevance 0.80 Pain Relevance 0.19
5XFAD transgenic mice have been introduced as an aggressive amyloid model that co-overexpresses human amyloid precursor protein (APP) and presenilin-1 (PS1) harboring five familial AD (FAD) mutations [8], [28]. 5XFAD mice begin to develop visible amyloid deposition as early as 2 months of age and exhibit memory declines on hippocampus-dependent tasks between 4–6 months with moderate A?
Positive_regulation (overexpresses) of Gene_expression (overexpresses) of presenilin-1 in hippocampus associated with targeted disruption, alzheimer's dementia, hippocampus and disease
20) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 1.16 Pain Relevance 0.05

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