INT111068

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.35
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 4.17
Pain Relevance 4.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Psenen) endoplasmic reticulum (Psenen)
Psenen (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 48 99.06 Very High Very High Very High
Abeta 57 98.48 Very High Very High Very High
Inflammation 3 32.24 Quite Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 38 99.92 Very High Very High Very High
INFLAMMATION 16 98.94 Very High Very High Very High
Disease 8 97.00 Very High Very High Very High
Targeted Disruption 8 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity.
Regulation (modulation) of gamma-secretase associated with inflammation, alzheimer's dementia and cinod
1) Confidence 0.35 Published 2003 Journal J. Biol. Chem. Section Title Doc Link 12805356 Disease Relevance 0.48 Pain Relevance 0.73
In sum, these results strongly suggest that NSAIDs represent a founding group of compounds that lower A beta 42 production by direct modulation of gamma-secretase activity or its substrate.
Regulation (modulation) of gamma-secretase associated with cinod
2) Confidence 0.35 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12805356 Disease Relevance 0.20 Pain Relevance 0.61
Abeta42-lowering nonsteroidal anti-inflammatory drugs (NSAIDs) constitute the founding members of a new class of gamma-secretase modulators that avoid side effects of pan-gamma-secretase inhibitors on NOTCH processing and function, holding promise as potential disease-modifying agents for Alzheimer disease (AD).
Regulation (effects) of pan-gamma-secretase associated with inflammation, alzheimer's dementia, cinod and disease
3) Confidence 0.32 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17573346 Disease Relevance 0.53 Pain Relevance 0.33
These modulators are active in cell-free gamma-secretase assays indicating that they directly target the gamma-secretase complex.
Regulation (target) of gamma-secretase
4) Confidence 0.32 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17573346 Disease Relevance 0.53 Pain Relevance 0.39
Moreover, we find that presenilin-1 (PS1) mutations, which affect gamma-secretase activity, differentially modulate the cellular A beta 42 response to NSAID treatment.
Regulation (affect) of gamma-secretase associated with cinod
5) Confidence 0.25 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12805356 Disease Relevance 0.38 Pain Relevance 0.79
Modulation of gamma-secretase activity by sulindac sulfide reduced Abeta(42) in the case of wild type PS1 and two FAD-associated PS1 mutations (M146L and A285V).
Regulation (Modulation) of gamma-secretase associated with alzheimer's dementia and abeta
6) Confidence 0.15 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 17962197 Disease Relevance 0.71 Pain Relevance 0.65
Gamma-secretase can be blocked by selective inhibitors but can also be modulated by a subset of non-steroidal anti-inflammatory drugs, including sulindac sulfide.
Regulation (modulated) of Gamma-secretase associated with inflammation and cinod
7) Confidence 0.07 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 17962197 Disease Relevance 0.59 Pain Relevance 0.37
Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation.
Regulation (modulation) of gamma-secretase associated with alzheimer's dementia
8) Confidence 0.07 Published 2008 Journal J. Biol. Chem. Section Title Doc Link 17962197 Disease Relevance 0.75 Pain Relevance 0.45

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox