INT111070

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 9.47
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Psen1) Golgi apparatus (Psen1) endoplasmic reticulum (Psen1)
intracellular (Psen1) embryo development (Psen1) protein complex (Psen1)
Anatomy Link Frequency
brain 4
hippocampus 4
cleavage 2
vesicles 2
Psen1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 125 100.00 Very High Very High Very High
Eae 22 100.00 Very High Very High Very High
cINOD 130 97.48 Very High Very High Very High
cytokine 92 91.68 High High
cva 8 90.48 High High
Inflammation 249 71.84 Quite High
metalloproteinase 4 70.08 Quite High
Inflammatory response 35 59.44 Quite High
imagery 24 41.16 Quite Low
Thalamus 32 39.44 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 855 100.00 Very High Very High Very High
Cognitive Disorder 237 100.00 Very High Very High Very High
Alzheimer's Dementia 778 99.98 Very High Very High Very High
Amyloid Plaque 194 99.26 Very High Very High Very High
Disease 854 96.32 Very High Very High Very High
Urological Neuroanatomy 23 93.76 High High
Stress 81 92.60 High High
Neurodegenerative Disease 62 91.44 High High
Hemorrhage 8 90.48 High High
Dementia 53 89.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Absence of PS1 or the expression of a loss of function PS1 variant resulted in increased budding/generation of APP-containing vesicles from both ER and TGN with a concomitant increase in complex glycosylation and cell surface appearance of APP [29,94].
Negative_regulation (Absence) of Gene_expression (expression) of PS1 in vesicles
1) Confidence 0.42 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.49 Pain Relevance 0.03
Deletions and substitutions near the putative endoproteolytic cleavage sites between Thr291 and Ala299 [17] abolished PS1 endoproteolysis, but the resulting stable holoprotein still retained ?
Negative_regulation (abolished) of Gene_expression (endoproteolysis) of PS1 in cleavage
2) Confidence 0.42 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0 Pain Relevance 0
For example, the heavily glycosylated type I membrane protein nicastrin does not mature and exit the ER in cells lacking PS1 expression [60].
Negative_regulation (lacking) of Neg (lacking) Gene_expression (expression) of PS1
3) Confidence 0.42 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0 Pain Relevance 0
Transgenic overexpression of human PS1 in mice replaces endogenous mouse PS1 by a highly selective and compensatory mechanism, and the extent of replacement is proportional to the level of exogenous PS1, which suggests that exogenous and endogenous PS compete for limiting cellular factors [16,20].
Negative_regulation (replaces) of Gene_expression (overexpression) of PS1 associated with targeted disruption
4) Confidence 0.42 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.18 Pain Relevance 0
accumulation and amyloid plaques in the brain of APP transgenic mice lacking PS1 expression (Saura et al., 2005) (Figure 2).
Negative_regulation (lacking) of Gene_expression (expression) of PS1 in brain associated with targeted disruption and amyloid plaque
5) Confidence 0.42 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 0.93 Pain Relevance 0
In contrast, expression of the PS1-Delta Exon9 mutation strongly diminishes the A beta 42 response, showing that PS1 mutations can modulate the cellular drug response to NSAID treatment both positively and negatively.
Negative_regulation (diminishes) of Gene_expression (expression) of PS1 associated with cinod
6) Confidence 0.41 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12805356 Disease Relevance 0.35 Pain Relevance 0.86
Consistent with a role of PS on tau phosphorylation, overexpression of mutant PS1 in mice results in activation of GSK-3?
Negative_regulation (role) of Gene_expression (overexpression) of mutant PS1 associated with eae
7) Confidence 0.36 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 1.29 Pain Relevance 0.17
are present, whereas in old APP/PS1 mice (15-month-old) neurodegeneration in the hippocampus becomes clear, and cognitive impairment and A?
Negative_regulation (old) of Gene_expression (neurodegeneration) of PS1 in hippocampus associated with cognitive disorder and hippocampus
8) Confidence 0.35 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.99 Pain Relevance 0.05
This suggests that PS1 conformation could be a reliable predictor of A?
Negative_regulation (predictor) of Gene_expression (conformation) of PS1
9) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0 Pain Relevance 0
levels generally revealed significantly higher amyloid levels in the PS1/APPsw mouse brain slices compared to TgAPPsw (for soluble A?
Negative_regulation (levels) of Gene_expression (/) of PS1 in brain associated with alzheimer's dementia
10) Confidence 0.30 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC555557 Disease Relevance 0.51 Pain Relevance 0.29
deposition in the hippocampus of the APPswe/PS1?
Negative_regulation (deposition) of Gene_expression (hippocampus) of PS1 in hippocampus associated with hippocampus
11) Confidence 0.28 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2952897 Disease Relevance 0.81 Pain Relevance 0.09
The absence of presenilin 1 prevented the formation of A?
Negative_regulation (prevented) of Neg (absence) Gene_expression (absence) of presenilin 1
12) Confidence 0.26 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 1.03 Pain Relevance 0.07
However, a cognitive deficit (object recognition test) was still present in the hAPP [V717I] × PS1 ?
Negative_regulation (deficit) of Gene_expression (present) of PS1 associated with cognitive disorder
13) Confidence 0.26 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.93 Pain Relevance 0.08
In a APPSwe/L × PS1 model, most A?
Negative_regulation (/) of Gene_expression (model) of PS1
14) Confidence 0.23 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.19 Pain Relevance 0.05
In C3-3 mice crossed with mice expressing a mutant PS1, the A?
Negative_regulation (crossed) of Gene_expression (expressing) of PS1
15) Confidence 0.23 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.36 Pain Relevance 0
APP/PS1 double Tg mice exhibit accelerated A?
Negative_regulation (/) of Gene_expression (exhibit) of PS1 associated with targeted disruption
16) Confidence 0.21 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.97 Pain Relevance 0.04
appears to be due to several mechanisms, including altering APP and secretase mobility, reducing the expression of presenilin 1 and gamma secretase activity [137], and induction of increased expression of a late-onset, AD-depleted, anti-amyloidogenic chaperone, SorLa/LR11 [164].
Negative_regulation (reducing) of Gene_expression (expression) of presenilin 1 associated with disease
17) Confidence 0.15 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2876259 Disease Relevance 0.45 Pain Relevance 0.03
35 boxes can be easily predicted for pS1, in the case of pS2, it is possible to predict only ?
Spec (possible) Negative_regulation (possible) of Gene_expression (predicted) of pS1
18) Confidence 0.04 Published 2010 Journal Mol Genet Genomics Section Body Doc Link PMC2939334 Disease Relevance 0 Pain Relevance 0

General Comments

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