INT111072

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Context Info
Confidence 0.98
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 26
Total Number 27
Disease Relevance 14.07
Pain Relevance 2.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bace1) peptidase activity (Bace1) Golgi apparatus (Bace1)
endoplasmic reticulum (Bace1) enzyme binding (Bace1)
Anatomy Link Frequency
cleavage 13
plaques 1
Bace1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 104 97.48 Very High Very High Very High
Inflammation 261 89.68 High High
Neuronal excitability 26 89.68 High High
hyperexcitability 8 88.64 High High
Action potential 21 88.16 High High
potassium channel 21 87.36 High High
cytokine 96 86.76 High High
ischemia 123 84.84 Quite High
sodium channel 71 83.92 Quite High
Nav1.2 32 81.68 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 930 100.00 Very High Very High Very High
Injury 116 98.56 Very High Very High Very High
Stress 591 98.28 Very High Very High Very High
Disease 2086 98.26 Very High Very High Very High
Apoptosis 260 97.84 Very High Very High Very High
Cognitive Disorder 387 97.08 Very High Very High Very High
Amyloid Plaque 265 95.84 Very High Very High Very High
Convulsion 100 94.60 High High
Toxicity 47 94.28 High High
Disease Progression 48 93.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Koh and colleagues recently reported the lysosomal degradation of BACE1, and mutation of the di-leucine motif prevented lysosomal BACE1 accumulation following inhibition of lysosomal hydrolases [242].
Protein_catabolism (degradation) of BACE1
1) Confidence 0.98 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0 Pain Relevance 0
Degradation of BACE1 occurs, in part at least, in the lysosomal pathway [242] and a role for GGA3 in the targeting of cargo to the lysosome has been previously reported [241].
Protein_catabolism (Degradation) of BACE1
2) Confidence 0.98 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.86 Pain Relevance 0.07
Degradation of BACE1 occurs, in part at least, in the lysosomal pathway [134] and a role for GGA3 in the targeting of cargo to the lysosome has been previously reported [133].
Protein_catabolism (Degradation) of BACE1
3) Confidence 0.98 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.61 Pain Relevance 0.07
The Swedish mutation enhances the cleavage of APP by BACE1.
Protein_catabolism (cleavage) of BACE1 in cleavage
4) Confidence 0.87 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.22 Pain Relevance 0
-secretase cleavage of LRP enables release of the LRP-intracellular domain (LRP-ICD).
Protein_catabolism (cleavage) of secretase in cleavage
5) Confidence 0.87 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.46 Pain Relevance 0
Alternatively, BACE1 cleavage of APP leading to AICD-mediated gene transcription may be important for cognitive function [67].
Protein_catabolism (cleavage) of BACE1 in cleavage associated with cognitive disorder
6) Confidence 0.87 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.43 Pain Relevance 0.09
-secretase cleavage of LRP enables release of the LRP-intracellular domain (LRP-ICD).
Protein_catabolism (cleavage) of secretase in cleavage
7) Confidence 0.87 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.24 Pain Relevance 0
The Swedish mutation enhances the cleavage of APP by BACE1.
Protein_catabolism (cleavage) of BACE1 in cleavage
8) Confidence 0.87 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.35 Pain Relevance 0
Several mechanisms are proposed to induce the BACE1 elevation associated with AD; for example, caspase-3-dependent inactivation of GGA3 leading to decreased lysosomal degradation of BACE1 [38], [39], increased phosphorylation of the translation initiation factor eIF2?
Protein_catabolism (degradation) of BACE1 associated with disease
9) Confidence 0.87 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 0.44 Pain Relevance 0
BACE1 can be degraded by at least three mechanisms: 1. endoproteolysis within its catalytic domain [245]; 2. the ubiquitin-proteasomal pathway [246]; 3. the lysosomal path-way [242].
Protein_catabolism (degraded) of BACE1
10) Confidence 0.86 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.12 Pain Relevance 0.03
Indeed, caspase activation during programmed cell death induced the BACE1 increase via a post-translational stabilization of BACE1 and a significant impairment in BACE1 degradation and turnover.
Protein_catabolism (degradation) of BACE1 associated with apoptosis
11) Confidence 0.86 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 1.09 Pain Relevance 0.14
Evidence for altered BACE1 degradation first came from Puglielli and colleagues who reported that the lipid second messenger, ceremide, increases BACE1 half-life and the generation of A?
Protein_catabolism (degradation) of BACE1
12) Confidence 0.86 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.28 Pain Relevance 0.04
The activity of the BACE1 enzyme is influenced by a number of factors, including splicing events, as previously discussed, the amount of BACE1 protein present (which is related directly to transcriptional and post-transcriptional events, along with altered BACE1 degradation), in addition to a variety of post-translational and cell biological events.
Protein_catabolism (degradation) of BACE1
13) Confidence 0.86 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.33 Pain Relevance 0
Indeed, caspase activation during programmed cell death induced the BACE1 increase via a post-translational stabilization of BACE1 and a significant impairment in BACE1 degradation and turnover.
Protein_catabolism (degradation) of BACE1 associated with apoptosis
14) Confidence 0.86 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 1.12 Pain Relevance 0.15
-cleavage of APP in BACE1+/?
Protein_catabolism (cleavage) of BACE1 in cleavage
15) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 0.51 Pain Relevance 0
The cleavage by BACE1 of the ?
Protein_catabolism (cleavage) of BACE1 in cleavage
16) Confidence 0.77 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2933677 Disease Relevance 0.50 Pain Relevance 0.28
subunits are BACE1 substrates, and BACE1 cleavage generates a membrane-bound ?
Protein_catabolism (cleavage) of BACE1 in cleavage
17) Confidence 0.65 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.07 Pain Relevance 0.23
Increased BACE1 protein and/or activity in the absence of altered BACE1 mRNA levels might be caused by several factors including post-transcriptional processing, a change in the rate of BACE1 translation and/or alterations in BACE1 protein stability.
Protein_catabolism (stability) of BACE1 protein
18) Confidence 0.65 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.86 Pain Relevance 0.19
-secretase cleavage, are increased several fold over levels found in untransfected cells, and A?
Protein_catabolism (cleavage) of secretase in cleavage
19) Confidence 0.65 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.07 Pain Relevance 0
BACE1 activity is also affected by the microenvironment, being stimulated by various lipid moieties [219], and the stability of BACE1 may be affected by ischemic conditions [185].
Protein_catabolism (stability) of BACE1
20) Confidence 0.65 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 1.53 Pain Relevance 0.04

General Comments

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