INT111073

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Context Info
Confidence 0.76
First Reported 2003
Last Reported 2011
Negated 5
Speculated 1
Reported most in Body
Documents 167
Total Number 168
Disease Relevance 78.65
Pain Relevance 15.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Psen1) Golgi apparatus (Psen1) endoplasmic reticulum (Psen1)
intracellular (Psen1) embryo development (Psen1) protein complex (Psen1)
Anatomy Link Frequency
brain 13
hippocampus 5
microglia 3
cleavage 2
plaque 2
Psen1 (Mus musculus)
Psen1 - L166P (4) Psen1 - M146L (1)
Pain Link Frequency Relevance Heat
Hippocampus 553 100.00 Very High Very High Very High
bDMF 40 100.00 Very High Very High Very High
adenocard 12 100.00 Very High Very High Very High
Eae 149 99.96 Very High Very High Very High
imagery 678 99.84 Very High Very High Very High
Pyramidal cell 40 99.84 Very High Very High Very High
cINOD 1050 99.52 Very High Very High Very High
glial activation 60 99.04 Very High Very High Very High
Inflammation 1440 98.96 Very High Very High Very High
cytokine 689 98.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 7203 100.00 Very High Very High Very High
Targeted Disruption 3183 100.00 Very High Very High Very High
Alzheimer's Dementia 3150 100.00 Very High Very High Very High
Cognitive Disorder 1095 99.80 Very High Very High Very High
Neuroblastoma 24 99.56 Very High Very High Very High
Brain Injury 329 99.54 Very High Very High Very High
Amyloid Plaque 782 99.10 Very High Very High Very High
INFLAMMATION 1952 98.96 Very High Very High Very High
Hypoxia 284 98.76 Very High Very High Very High
Syndrome 208 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, expression of chimeric PS1/PS2 holoprotein is endoproteolysed and forms heteromeric assemblies made of PS1NTF•PS2CTF [21].
Gene_expression (expression) of PS1
1) Confidence 0.76 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.14 Pain Relevance 0
Transgenic overexpression of human PS1 in mice replaces endogenous mouse PS1 by a highly selective and compensatory mechanism, and the extent of replacement is proportional to the level of exogenous PS1, which suggests that exogenous and endogenous PS compete for limiting cellular factors [16,20].
Gene_expression (overexpression) of PS1 associated with targeted disruption
2) Confidence 0.76 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.18 Pain Relevance 0
In human brain, PS1 protein is highly expressed in pyramidal neurons of the hippocampus and neocortex, magnocellular neurons of the basal forebrain, brainstem motoneurons and some interneuron populations (Kim et al., 1997; Lah et al., 1997).
Gene_expression (expressed) of PS1 in neurons associated with medulla, pyramidal cell, interneuron and hippocampus
3) Confidence 0.76 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 0.18 Pain Relevance 0.24
However, PS1 expression is upregulated in reactive astrocytes and activated microglia under pathological conditions such as those occurring in AD, brain injury and hypoxia (Weggen et al., 1998; Peers et al., 2004; Nadler et al., 2008).


Gene_expression (expression) of PS1 in microglia associated with hypoxia, disease and brain injury
4) Confidence 0.76 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 0.28 Pain Relevance 0.22
In contrast, expression of the PS1-Delta Exon9 mutation strongly diminishes the A beta 42 response, showing that PS1 mutations can modulate the cellular drug response to NSAID treatment both positively and negatively.
Gene_expression (expression) of PS1 associated with cinod
5) Confidence 0.75 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12805356 Disease Relevance 0.35 Pain Relevance 0.86
Overexpression of the PS1-M146L mutation enhances the cellular drug response to A beta 42 lowering NSAIDs as compared with cells expressing wild-type PS1.
Gene_expression (Overexpression) of PS1 associated with cinod
6) Confidence 0.75 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12805356 Disease Relevance 0.37 Pain Relevance 0.85
This was confirmed in a mouse model with transgenic expression of the PS1-L166P mutation, in which the potent gamma-secretase inhibitor LY-411575 failed to reduce brain levels of soluble Abeta42.
Gene_expression (expression) of PS1 (L166P) in brain associated with targeted disruption
7) Confidence 0.74 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17573346 Disease Relevance 0.23 Pain Relevance 0.29
For example, large-scale gene expression profiling in brains of conditional PS1 knockout mice and transgenic mice expressing wild type or FAD-linked mutant PS1 suggests that the FAD-linked PS1 variant produces transcriptome changes primarily by gain of aberrant function [86].
Gene_expression (expressing) of mutant PS1 in brains associated with targeted disruption and disease
8) Confidence 0.66 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.94 Pain Relevance 0.07
40 ratio in cells or transgenic mice expressing mutant PS1 or PS2 genes (Selkoe, 2002).
Gene_expression (expressing) of mutant PS1 associated with targeted disruption
9) Confidence 0.66 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 0.66 Pain Relevance 0
As described above, overexpression of PS1 alone neither substantially increases the levels of mature PS1 derivatives nor elevates A?
Gene_expression (derivatives) of PS1
10) Confidence 0.66 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.21 Pain Relevance 0.03
For example, deletion of TM1 through TM2 (PS1?
Gene_expression (through) of PS1 in TM1
11) Confidence 0.66 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0 Pain Relevance 0
An independent C. elegans genetic screen identified aph-1 and pen-2 as enhancers of sel-12/Presenilin function, and showed that aph-2, aph-1 and pen-2 are required for Notch signaling, PS1 accumulation, and ?
Gene_expression (function) of Presenilin in Notch
12) Confidence 0.66 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.07 Pain Relevance 0
For example, the heavily glycosylated type I membrane protein nicastrin does not mature and exit the ER in cells lacking PS1 expression [60].
Neg (lacking) Gene_expression (expression) of PS1
13) Confidence 0.66 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0 Pain Relevance 0
Furthermore, residues critical for both PS1 endoproteolysis and ?
Gene_expression (endoproteolysis) of PS1
14) Confidence 0.66 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0 Pain Relevance 0
Transgenic mice with conditional ablation of PS1 and expression of FAD-associated human PS variants have provided some clues about the physiological consequences and stages in the development of disease.
Gene_expression (expression) of PS1 associated with targeted disruption and disease
15) Confidence 0.66 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.82 Pain Relevance 0.06
As described above, overexpression of PS1 alone neither substantially increases the levels of mature PS1 derivatives nor elevates A?
Gene_expression (overexpression) of PS1
16) Confidence 0.66 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.26 Pain Relevance 0.03
In several cases PS1/?
Gene_expression (/) of PS1
17) Confidence 0.66 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.30 Pain Relevance 0.05
-secretase containing PS1 or PS2.
Gene_expression (containing) of PS1
18) Confidence 0.66 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.77 Pain Relevance 0
Similarly, the absence of PS1 or the expression of FAD-linked PS1 mutant results in increased glycogen synthase kinase-3?
Gene_expression (expression) of PS1 associated with disease
19) Confidence 0.66 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.70 Pain Relevance 0
PS1 has been shown to be involved in the subcellular trafficking of APP and FAD-linked PS1 variants increase the retention of substrate in compartments where ?
Gene_expression (involved) of PS1 associated with disease
20) Confidence 0.66 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.64 Pain Relevance 0.08

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