INT111078

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Context Info
Confidence 0.05
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cnr1, Cnr2) signal transducer activity (Cnr1, Cnr2) aging (Cnr1)
response to stress (Cnr1)
Cnr1 (Rattus norvegicus)
Cnr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cannabinoid 11 99.98 Very High Very High Very High
agonist 3 98.56 Very High Very High Very High
cannabis 2 94.28 High High
Cannabinoid receptor 4 91.84 High High
Central nervous system 3 72.08 Quite High
Inflammation 1 64.72 Quite High
Endocannabinoid 2 63.84 Quite High
Thermal hyperalgesia 1 63.68 Quite High
Hippocampus 1 57.20 Quite High
Eae 1 50.56 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cannabinoids act primarily via two types of receptor, CB1 and CB2, with CB1 receptors mediating most of the central actions of cannabinoids.
CB1 Binding (act) of CB2 associated with cannabinoid
1) Confidence 0.05 Published 2002 Journal ScientificWorldJournal Section Abstract Doc Link 12805989 Disease Relevance 0 Pain Relevance 0.62
Indole ring substitutions had varying effects on CB 2 and CB 1 binding, but were generally detrimental to agonist activity.
CB 1 Binding (binding) of CB 2 associated with agonist
2) Confidence 0.01 Published 2008 Journal J. Med. Chem. Section Abstract Doc Link 18311894 Disease Relevance 0 Pain Relevance 0.30

General Comments

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