INT111078

Context Info Confidence 0.05 First Reported 2002 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0 Pain Relevance 0.92

plasma membrane (Cnr1, Cnr2) signal transducer activity (Cnr1, Cnr2) aging (Cnr1) response to stress (Cnr1)

Cnr1 (Rattus norvegicus) Cnr2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Cannabinoid 11 99.98 agonist 3 98.56 cannabis 2 94.28 Cannabinoid receptor 4 91.84 Central nervous system 3 72.08 Inflammation 1 64.72 Endocannabinoid 2 63.84 Thermal hyperalgesia 1 63.68 Hippocampus 1 57.20 Eae 1 50.56

Disease Link Frequency Relevance Heat Hyperalgesia 1 5.00 INFLAMMATION 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Cannabinoids act primarily via two types of receptor, CB1 and CB2, with CB1 receptors mediating most of the central actions of cannabinoids.

CB1 Binding (act) of CB2 associated with cannabinoid

1) Confidence 0.05 Published 2002 Journal ScientificWorldJournal Section Abstract Doc Link 12805989 Disease Relevance 0 Pain Relevance 0.62

Indole ring substitutions had varying effects on CB 2 and CB 1 binding, but were generally detrimental to agonist activity.

CB 1 Binding (binding) of CB 2 associated with agonist

2) Confidence 0.01 Published 2008 Journal J. Med. Chem. Section Abstract Doc Link 18311894 Disease Relevance 0 Pain Relevance 0.30

General Comments

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