INT111081

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Context Info
Confidence 0.75
First Reported 2002
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 19
Total Number 45
Disease Relevance 51.09
Pain Relevance 26.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (CA1) Golgi apparatus (CA1) cytoplasm (CA1)
Anatomy Link Frequency
neurons 8
synovium 5
synovial fluid 4
neuronal 2
proximal 1
CA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 2322 99.84 Very High Very High Very High
Pyramidal cell 61 99.84 Very High Very High Very High
Osteoarthritis 972 99.60 Very High Very High Very High
Nav1.6 3 99.52 Very High Very High Very High
rheumatoid arthritis 1027 99.06 Very High Very High Very High
Chronic pancreatitis 14 98.64 Very High Very High Very High
long-term potentiation 110 98.16 Very High Very High Very High
Inflammation 231 97.12 Very High Very High Very High
Hippocampus 100 92.12 High High
cINOD 108 91.28 High High
Disease Link Frequency Relevance Heat
Pancreatitis 16 100.00 Very High Very High Very High
Low Back Pain 2295 99.84 Very High Very High Very High
Hypercalcemia 297 99.72 Very High Very High Very High
Stress 1431 99.62 Very High Very High Very High
Frailty 1026 99.60 Very High Very High Very High
Uveitis 81 99.36 Very High Very High Very High
Rheumatoid Arthritis 1027 99.06 Very High Very High Very High
Calcification 159 98.12 Very High Very High Very High
Apoptosis 65 97.60 Very High Very High Very High
Hyperplasia 82 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We thus detected especially high expression of CA1 in the synovial tissues of AS patients.
Gene_expression (expression) of CA1 associated with spinal inflammation
1) Confidence 0.75 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 1.60 Pain Relevance 1.20
Our results suggest that elevated expression of CA1 in the diseased synovial tissues plays a role in new bone formation and bone resorption.
Gene_expression (expression) of CA1 associated with hypercalcemia
2) Confidence 0.75 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 2.00 Pain Relevance 0.68
Increased CA1 expression in the synovium of AS patients may lead to improper mineralization by accelerating calcium salt deposition.
Gene_expression (expression) of CA1 in synovium associated with spinal inflammation
3) Confidence 0.75 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 0.66 Pain Relevance 0.40
Among the five OA synovial samples, only one sample had a relatively high CA1 expression.
Gene_expression (expression) of CA1 associated with osteoarthritis
4) Confidence 0.75 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 1.08 Pain Relevance 0.69
Immunohistochemistry detected CA1 expression in all AS synovial tissues (100%) and yielded high intensity signals.
Gene_expression (expression) of CA1 associated with spinal inflammation
5) Confidence 0.75 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 1.01 Pain Relevance 0.65
Compared to the average level of the OA samples, fluid samples from AS patients had a two-fold or greater increase in CA1 expression in 31 samples (77.5%).
Gene_expression (expression) of CA1 associated with spinal inflammation and osteoarthritis
6) Confidence 0.75 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 1.56 Pain Relevance 1.09
The increased expression of CA1 was confirmed by individually investigating synovial samples from each disease using western blot analysis.
Gene_expression (expression) of CA1 associated with disease
7) Confidence 0.75 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 1.90 Pain Relevance 1.24
The high expression levels of CA1 in the synovial tissues of patients with AS may partially explain the strong association of the two diseases.
Gene_expression (expression) of CA1 associated with spinal inflammation and disease
8) Confidence 0.75 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 1.81 Pain Relevance 0.54
Overexpression of CA1 in the synovium of AS patients may be involved in bone resorption of the disease.
Gene_expression (Overexpression) of CA1 in synovium associated with spinal inflammation, hypercalcemia and disease
9) Confidence 0.75 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 1.64 Pain Relevance 0.48
Therefore, overexpression of CA1 in the synovium of AS patients may lead to CaCO3 deposition in diseased tissues.
Gene_expression (overexpression) of CA1 in synovium associated with spinal inflammation
10) Confidence 0.75 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 0.51 Pain Relevance 0.35
Using a highly sensitive electron microscopic immunogold technique, we revealed the presence of the Nav1.6 subunit in hippocampal CA1 PC proximal and distal dendrites.
Gene_expression (proximal) of CA1 in proximal associated with nav1.6
11) Confidence 0.65 Published 2010 Journal Science Section Abstract Doc Link 20466935 Disease Relevance 0 Pain Relevance 0.38
Expression of CA1 in synovial fluid
Gene_expression (Expression) of CA1 in synovial fluid
12) Confidence 0.65 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 1.48 Pain Relevance 1.00
In the present study, a proteomic approach exclusively identified the increased expression of CA1 in AS synovial membranes as compared with RA and OA samples.
Gene_expression (expression) of CA1 associated with spinal inflammation, rheumatoid arthritis and osteoarthritis
13) Confidence 0.65 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 1.94 Pain Relevance 1.27
Furthermore, they found that CA1 promotes the formation of CaCO3 and the precipitant quickly settles [14].
Gene_expression (promotes) of CA1
14) Confidence 0.65 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 0.50 Pain Relevance 0.42
CA1 was detected in six samples of synovial membranes from OA patients (60%); the enzyme was detected in the upper lining within the thin layer of cells.
Gene_expression (detected) of CA1 in upper associated with osteoarthritis
15) Confidence 0.65 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 1.28 Pain Relevance 0.88
Among the 40 RA synovial fluid samples, 12 samples had higher levels of CA1 (30%, O.D. > 2.0).
Gene_expression (levels) of CA1 in synovial fluid associated with rheumatoid arthritis
16) Confidence 0.65 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 1.72 Pain Relevance 1.14
These proteins are Gla protein, osteoprotegerin, fibrillin I and carbonic anhydrase (all produced by vascular smooth muscle cells).
Gene_expression (produced) of carbonic anhydrase in smooth muscle cells
17) Confidence 0.58 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1326214 Disease Relevance 1.28 Pain Relevance 0
Furthermore, the ELISA detected higher levels of CA1 in the synovial fluid from patients with AS compared to the OA samples.
Gene_expression (detected) of CA1 in synovial fluid associated with spinal inflammation and osteoarthritis
18) Confidence 0.58 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 1.92 Pain Relevance 1.23
The current study detected increased expression of CA1 in the synovial tissue of AS patients.
Gene_expression (expression) of CA1 associated with spinal inflammation
19) Confidence 0.58 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 2.24 Pain Relevance 0.98
The proteomic approach revealed significantly increased expression of carbonic anhydrase I (CA1) in the synovial membrane of patients with AS as compared with the RA and OA tissue samples.
Gene_expression (expression) of carbonic anhydrase I associated with spinal inflammation, rheumatoid arthritis and osteoarthritis
20) Confidence 0.58 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC3012668 Disease Relevance 2.13 Pain Relevance 1.30

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