INT111081
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
We thus detected especially high expression of CA1 in the synovial tissues of AS patients. | |||||||||||||||
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Our results suggest that elevated expression of CA1 in the diseased synovial tissues plays a role in new bone formation and bone resorption. | |||||||||||||||
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Increased CA1 expression in the synovium of AS patients may lead to improper mineralization by accelerating calcium salt deposition. | |||||||||||||||
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Among the five OA synovial samples, only one sample had a relatively high CA1 expression. | |||||||||||||||
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Immunohistochemistry detected CA1 expression in all AS synovial tissues (100%) and yielded high intensity signals. | |||||||||||||||
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Compared to the average level of the OA samples, fluid samples from AS patients had a two-fold or greater increase in CA1 expression in 31 samples (77.5%). | |||||||||||||||
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The increased expression of CA1 was confirmed by individually investigating synovial samples from each disease using western blot analysis. | |||||||||||||||
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The high expression levels of CA1 in the synovial tissues of patients with AS may partially explain the strong association of the two diseases. | |||||||||||||||
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Overexpression of CA1 in the synovium of AS patients may be involved in bone resorption of the disease. | |||||||||||||||
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Therefore, overexpression of CA1 in the synovium of AS patients may lead to CaCO3 deposition in diseased tissues. | |||||||||||||||
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Using a highly sensitive electron microscopic immunogold technique, we revealed the presence of the Nav1.6 subunit in hippocampal CA1 PC proximal and distal dendrites. | |||||||||||||||
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Expression of CA1 in synovial fluid | |||||||||||||||
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In the present study, a proteomic approach exclusively identified the increased expression of CA1 in AS synovial membranes as compared with RA and OA samples. | |||||||||||||||
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Furthermore, they found that CA1 promotes the formation of CaCO3 and the precipitant quickly settles [14]. | |||||||||||||||
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CA1 was detected in six samples of synovial membranes from OA patients (60%); the enzyme was detected in the upper lining within the thin layer of cells. | |||||||||||||||
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Among the 40 RA synovial fluid samples, 12 samples had higher levels of CA1 (30%, O.D. > 2.0). | |||||||||||||||
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These proteins are Gla protein, osteoprotegerin, fibrillin I and carbonic anhydrase (all produced by vascular smooth muscle cells). | |||||||||||||||
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Furthermore, the ELISA detected higher levels of CA1 in the synovial fluid from patients with AS compared to the OA samples. | |||||||||||||||
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The current study detected increased expression of CA1 in the synovial tissue of AS patients. | |||||||||||||||
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The proteomic approach revealed significantly increased expression of carbonic anhydrase I (CA1) in the synovial membrane of patients with AS as compared with the RA and OA tissue samples. | |||||||||||||||
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