INT11109

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Context Info
Confidence 0.68
First Reported 1990
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 4.97
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpina1a) extracellular region (Serpina1a)
Anatomy Link Frequency
coronary artery 1
plasma 1
retinas 1
heart 1
Serpina1a (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 12 100.00 Very High Very High Very High
Pain 2 99.48 Very High Very High Very High
Inflammation 33 96.52 Very High Very High Very High
ischemia 4 91.04 High High
agonist 1 87.72 High High
chemokine 16 78.00 Quite High
Inflammatory stimuli 1 25.88 Quite Low
Inflammatory response 11 11.84 Low Low
fibrosis 5 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 45 100.00 Very High Very High Very High
Cv General 3 Under Development 7 100.00 Very High Very High Very High
Hypertension 4 100.00 Very High Very High Very High
Cyanosis 2 99.80 Very High Very High Very High
Pain 2 99.48 Very High Very High Very High
Diabetes Mellitus 7 99.40 Very High Very High Very High
Coronary Artery Disease 5 99.40 Very High Very High Very High
Acute-phase Reaction 4 98.88 Very High Very High Very High
Necrosis 5 97.04 Very High Very High Very High
INFLAMMATION 47 96.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study significant elevations of serum alpha-1-antitrypsin were noted in coronary artery disease and angina cases.
Positive_regulation (elevations) of alpha-1-antitrypsin in coronary artery associated with angina and coronary artery disease
1) Confidence 0.68 Published 1996 Journal Indian J Pathol Microbiol Section Abstract Doc Link 9009477 Disease Relevance 1.19 Pain Relevance 0.23
It is hypothesised that serum alpha-1-antitrypsin enhancement will not occur even though acute phase state exists if specific immune responses are also a part of the disease manifestation.
Positive_regulation (enhancement) of alpha-1-antitrypsin associated with acute-phase reaction and disease
2) Confidence 0.49 Published 1996 Journal Indian J Pathol Microbiol Section Abstract Doc Link 9009477 Disease Relevance 1.32 Pain Relevance 0.21
PR3–SERPIN A1 levels were similar in males and females, and in those with or without previous histories of hypertension, angina, AMI or heart failure, but were slightly elevated in those with diabetes [547.0 (76.9–4035.5) ng/ml] compared with non-diabetic patients [495.1 (29.3–3118.2) ng/ml; P<0.018].
Positive_regulation (elevated) of SERPIN A1 in heart associated with angina, diabetes mellitus, hypertension and myocardial infarction
3) Confidence 0.13 Published 2010 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2999885 Disease Relevance 0.80 Pain Relevance 0.10
A transient increase of MCP-1 protein and mRNA at PI-1 was detected in the retinas following subretinal injection.
Positive_regulation (increase) of PI-1 in retinas
4) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756629 Disease Relevance 0.63 Pain Relevance 0.19
Estimation of antithrombin III, alpha 2 macroglobulin and alpha 1 antitrypsin in patients with stable and unstable angina and acute myocardial infarction (15 cases each) were carried out.
Positive_regulation (Estimation) of alpha 1 antitrypsin associated with angina and myocardial infarction
5) Confidence 0.02 Published 1990 Journal Indian Heart J Section Abstract Doc Link 1711506 Disease Relevance 0.68 Pain Relevance 0.22
PURPOSE: The purpose of this study was to investigate adverse reaction reports of pain and/or cyanosis attributed to alpha 1-proteinase inhibitor (A1PI), a plasma alpha-globulin protein used to treat A1PI deficiency.
Spec (investigate) Positive_regulation (attributed) of A1PI in plasma associated with pain and cyanosis
6) Confidence 0.01 Published 1992 Journal Am. J. Med. Section Abstract Doc Link 1534964 Disease Relevance 0.35 Pain Relevance 0.17

General Comments

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