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Context Info
Confidence 0.27
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.03
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Dusp1) nucleoplasm (Dusp1) nucleus (Dusp1)
cell cycle (Dusp1)
Dusp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 183 99.98 Very High Very High Very High
Lasting pain 46 99.20 Very High Very High Very High
dexamethasone 83 94.40 High High
Pain threshold 18 92.28 High High
Inflammation 24 92.24 High High
Nicotine 96 78.80 Quite High
Limbic system 2 72.80 Quite High
b2 receptor 29 68.72 Quite High
agonist 11 50.00 Quite Low
corticosteroid 1 50.00 Quite Low
Disease Link Frequency Relevance Heat
Stress 3 100.00 Very High Very High Very High
Pain 239 99.98 Very High Very High Very High
Apoptosis 38 99.20 Very High Very High Very High
Pancreatic Cancer 43 92.80 High High
INFLAMMATION 24 92.24 High High
Targeted Disruption 14 91.68 High High
Cancer 46 88.32 High High
Somatoform Disorder 2 88.24 High High
Carcinoma 3 70.80 Quite High
Breast Cancer 7 65.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moderate to strong MKP-1 immunoreactivity was present in the cancer cells, ductal cells of pancreatic intraepithelial neoplasia, and in tubular complexes in CP.
Regulation (immunoreactivity) of MKP-1
1) Confidence 0.27 Published 2003 Journal Gastroenterology Section Body Doc Link 12806617 Disease Relevance 0 Pain Relevance 0
Up-regulation of stress response (MAFK, IKBZ, SOCS3) and early growth response (c-Myc, c-Jun, c-Fos, DUSP1 and 6) genes as assessed by RT-qPCR and/or microarray profiling was unchanged.
Regulation (regulation) of DUSP1 associated with stress
2) Confidence 0.25 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2940888 Disease Relevance 0.19 Pain Relevance 0
This is in contrast to the effect of GCs in lymphoid cells and may involve cell type specific regulation of survival molecules such as SGK-1 and MKP-1 together with anti-apoptotic molecules such as X-IAP and Bcl-2.
Regulation (regulation) of MKP-1 associated with apoptosis
3) Confidence 0.08 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 0.92 Pain Relevance 0.19
Results from previous studies demonstrate that the pain ERP to experimental noxious stimuli is influenced by the presence of chronic pain complaints [30]–[32].
Regulation (influenced) of ERP associated with pain and lasting pain
4) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964315 Disease Relevance 1.10 Pain Relevance 1.10
Gender and age have previously been found to influence the ERP so they were included in order to correct for their influences [42], [43].
Regulation (influence) of ERP
5) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964315 Disease Relevance 0.66 Pain Relevance 0.69
They include both inhibition of the upstream negative regulator of JNK and p38 MAPKs called MAP kinase phosphatase-1 [48] and post-transcriptional/translational regulation of gene expressions [42,49].
Regulation (regulation) of MAP kinase phosphatase-1
6) Confidence 0.04 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.16 Pain Relevance 0.46

General Comments

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