INT111099

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.68
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 7.62
Pain Relevance 3.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Dusp1) nucleoplasm (Dusp1) nucleus (Dusp1)
cell cycle (Dusp1)
Anatomy Link Frequency
microglial cell 2
Dusp1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 19 100.00 Very High Very High Very High
dexamethasone 148 99.34 Very High Very High Very High
Inflammation 243 99.12 Very High Very High Very High
Inflammatory response 45 98.36 Very High Very High Very High
Endocannabinoid 32 98.02 Very High Very High Very High
Central nervous system 18 96.32 Very High Very High Very High
Multiple sclerosis 105 82.76 Quite High
Demyelination 6 78.28 Quite High
Inflammatory stimuli 15 72.40 Quite High
substance P 42 71.48 Quite High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 84 100.00 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 108 99.84 Very High Very High Very High
INFLAMMATION 306 99.12 Very High Very High Very High
Asthma 11 98.90 Very High Very High Very High
Breast Cancer 14 98.56 Very High Very High Very High
Apoptosis 91 98.08 Very High Very High Very High
Injury 23 93.64 High High
Lymphatic System Cancer 4 87.64 High High
Skin Cancer 4 86.60 High High
Metastasis 5 83.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: MKP-1 messenger RNA (mRNA) levels were increased in pancreatic cancer and chronic pancreatitis (CP) tissues.
Positive_regulation (increased) of MKP-1 messenger RNA
1) Confidence 0.68 Published 2003 Journal Gastroenterology Section Body Doc Link 12806617 Disease Relevance 0 Pain Relevance 0
An increase in functional MKP1 would reduce the sensitivity of the SCN to photic stimuli, and shut down the transcriptional mechanisms turned on by light.
Positive_regulation (increase) of MKP1
2) Confidence 0.57 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2216081 Disease Relevance 0 Pain Relevance 0.03
and IL6 responses appeared to be similar in the knockouts as judged by a comparable induction of the known feedback regulators of the major cytokine and growth factor signaling pathways such as SOCS3, IGFR1, DUSP1 and DUSP 6.
Positive_regulation (induction) of DUSP1 associated with cytokine
3) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0 Pain Relevance 0.05
Recently, it has been reported that during CNS inflammation, the endocannabinoid system is highly activated and the endocannabinoid an anandamide (AEA) protects neurons from inflammatory damage by CB (1/2) receptor-mediated rapid induction of mitogen-activated protein kinase phosphatase-1 (MKP-1) in microglial cell.
Positive_regulation (induction) of MKP-1 in microglial cell associated with endocannabinoid, inflammation and central nervous system
4) Confidence 0.37 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626929 Disease Relevance 1.16 Pain Relevance 0.80
Recently, it has been reported that during CNS inflammation, the endocannabinoid system is highly activated and the endocannabinoid an anandamide (AEA) protects neurons from inflammatory damage by CB (1/2) receptor-mediated rapid induction of mitogen-activated protein kinase phosphatase-1 (MKP-1) in microglial cell.
Positive_regulation (induction) of mitogen-activated protein kinase phosphatase-1 in microglial cell associated with endocannabinoid, inflammation and central nervous system
5) Confidence 0.37 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626929 Disease Relevance 1.11 Pain Relevance 0.80
In this context, the activation of genes such as dusp1 and nfkbia seems to counter-balance the inflammatory response to PAR activation by limiting prolonged activation of p38 MAPK and increased cytokine production.
Positive_regulation (activation) of dusp1 associated with inflammatory response and cytokine
6) Confidence 0.37 Published 2007 Journal BMC Physiol Section Abstract Doc Link PMC1853107 Disease Relevance 0.90 Pain Relevance 0.54
In this context, the activation of genes such as dusp1 and nfkbia seems to counter balance the inflammatory response to PAR activation by avoiding prolonged activation of p38 MAPK and increased cytokine production [68].
Positive_regulation (activation) of dusp1 associated with inflammatory response and cytokine
7) Confidence 0.37 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.44 Pain Relevance 0.21
This is the case of dusp1 that was found upregulated in both manuscripts.
Positive_regulation (upregulated) of dusp1
8) Confidence 0.37 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.45 Pain Relevance 0.16
For inhibition of apoptosis a functional glucocorticoid receptor (GR) is required and association with the transcriptional induction of survival molecules like serum and GC-inducible protein kinase-1 (SGK-1) and mitogen-activated protein kinase phosphatase-1 (MKP-1) is suggested in human established breast cancer cell lines [15].
Positive_regulation (induction) of MKP-1 associated with breast cancer and apoptosis
9) Confidence 0.13 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 1.80 Pain Relevance 0.26
A study looking at patients with severe asthma vs nonsevere asthma found a reduction in the dexamethasone-induced expression (messenger RNA) of MKP-1 and elevation in p38 activity in patients with severe asthma compared with patients with nonsevere asthma.92 However, no studies have looked at the GC-mediated induction of MKP-1 in COPD, and consequently no links have yet been made between the expression, activity, or signaling of MKP-1 and the reduction in GC responsiveness in COPD, although the potential is clearly explained.
Positive_regulation (induction) of MKP-1 associated with asthma, chronic obstructive pulmonary disease and dexamethasone
10) Confidence 0.07 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 0.99 Pain Relevance 0.08
During a time kinetic from 24 to 72 h, DEX strongly enhanced the levels of MKP-1, SGK1 and X-IAP, in several pancreatic cancer cell lines examined, while Bcl-2 expression was only marginally increased.
Positive_regulation (increased) of MKP-1 associated with pancreatic cancer and dexamethasone
11) Confidence 0.06 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 0.76 Pain Relevance 0.25

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox